Výsledky vyhledávání - "Mikihiko Obayashi"

Photochemical reaction of 21-methyl-20,21-diketosteroids: The formation of new 3',4',16.ALPHA.,17.ALPHA.-tetrahydrocyclobut[16,17]androstanes

Autor: Shunsaku Noguchi, Mikihiko Obayashi, Eiji Mizuta

Publikováno v: Chemical and Pharmaceutical Bulletin. 27:1679-1682

Exposure of 11β, 17α-dihydroxy-21-methylpregna-1, 4-diene-3, 20, 21-trione 17-acetate (Ia) and 17α-hydroxy-21-methylpregn-4-ene-3, 20, 21-trione 17-acetate (Ib) in EtOH to sunlight gave products having a new ring system in excellent yields, i.e.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbfdad3cb96ac526e8743e39db27577e
https://doi.org/10.1248/cpb.27.1679

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Potential Antiinflammatory Agents. II. Synthesis and Structure-Activity Relationships of 6-Chloro-5-cyclohexylindan-1-carboxylic Acid (TAI-284) and Related 5-Substituted Indan-1-carboxylic Acids

Autor: Isao Minamida, Shunsaku Noguchi, Mikihiko Obayashi, Shoji Kishimoto

Publikováno v: Chemical and Pharmaceutical Bulletin. 22:529-536

6-Chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284) and related 5-substituted indan-1-carboxylic acids were prepared for the evaluation of antiinflammatory action. Among them, TAI-284 showed the most potent activity, comparable to that of indometh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd616e773ee57910c1ea4bd246596891
https://doi.org/10.1248/cpb.22.529

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An improved synthesis of thyrotropin releasing hormone (TRH) and crystallization of the tartrate

Autor: Mikihiko Obayashi, Chitoshi Hatanaka, Osamu Nishimura, Noriaki Toukai, Masahiko Fujino

Publikováno v: Biochemical and Biophysical Research Communications. 60:1345-1350

An improved synthesis of thyrotropin releasing hormone (TRH), pGlu-His-Pro-NH2, is reported. Z-pGlu-ONB (N-hydroxy-5-norbornene-2,3-dicarboximide ester) was reacted with H-His-OH to yield a crystalline Z-pGlu-His-OH which was coupled with H-Pro-NH2 b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893b330c98c3992cfe8b2791bcb03ac8
https://doi.org/10.1016/0006-291x(74)90345-3

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Synthesis of some di- and tri-subsituted analogs of luteinzing hormone releasing hormone (LH-RH)

Autor: Mikihiko Obayashi, Shigeru Kobayashi, Tsunehiko Fukuda, Susumu Shinagawa, Masahiko Fujino

Publikováno v: Chemical and Pharmaceutical Bulletin. 23:2033-2038

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b1e5eb6a0d82e1d9baab54cfb9f811
https://doi.org/10.1248/cpb.23.2033

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Synthesis and anti-inflammatory activity of steroidal 17-yl-.ALPHA.-oxothiocarboxamides and related compounds

Autor: Seiji Kuzuna, Shunsaku Noguchi, Mikihiko Obayashi

Publikováno v: Chemical and Pharmaceutical Bulletin. 27:1352-1359

The Willgerodt-Kindler reaction of 21-chloro-20-ketosteroids (5) or sodium 21-thiosulfate derivatives of 20-ketosteroids (6) with sulfur in secondary amines gave the corresponding steroidal α-oxothiocarboxamides (3) in good yields. Among these compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7f4b0d52d2f26ccd0ebf8f5fef1e775
https://doi.org/10.1248/cpb.27.1352

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Anti-inflammatory Activity of 21-Methyl-20, 21-diketocorticosteroids. I. Anti-inflammatory Activity of 11β, 17α-Dihydroxy-21-methylpregna-1, 4-diene-3, 20, 21-trione 17-Acylates and Related Compounds

Autor: Shigeru Morimoto, Seiji Kuzuna, Mikihiko Obayashi

Publikováno v: YAKUGAKU ZASSHI. 99:380-386

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3308ef56e7f08001c21b3530fada56ed
https://doi.org/10.1248/yakushi1947.99.4_380

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Anti-inflammatory Activity of 21-Methyl-20, 21-diketocorticosteroids. II. Antiinflammatory Activity of 11β, 17α-Dihydroxy-21-methylpregna-1, 4-diene-3, 20, 21-trione 17-Acetate (TSC-5)

Autor: Seiji Kuzuna, Mikihiko Obayashi, Shigeru Morimoto, Kiyohisa Kawai

Publikováno v: YAKUGAKU ZASSHI. 99:871-879

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fc88d9fa8563f31d944816c5bfdedbb
https://doi.org/10.1248/yakushi1947.99.9_871

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Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis. IV. Synthesis of Gonadotropin-Releasing Hormone (Gn-RH or LH-RII/FSH-RH)

Autor: Shigeru Kobayashi, Masahiko Fujino, Tsunehiko Fukuda, Mikihiko Obayashi

Publikováno v: Chemical and Pharmaceutical Bulletin. 21:87-91

Gonadotropin-releasing hormone (Gn-RH or LH-RH/FSH-RH), a decapeptide amide (Pyr) Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, was synthesized by the use of the d-isobornyloxycarbonyl-protercting group for temporary protection of the all amino groups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49f83a4aeefaefda383bc4294713f8f9
https://doi.org/10.1248/cpb.21.87

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Synthesis and reduction of 11β,17α-dihydroxy-21-methylpregna-1,4-diene-3,20,21-trione 17-acylates

Autor: Takeshi Takahashi, Masayuki Imanishi, Mikihiko Obayashi, Shunsaku Noguchi, Hiroshi Otsuka

Publikováno v: Steroids. 12:9-27

11β,17α-Dihydroxy-21-methylpregna-1,4-diene-3,20,21-trione 17-acylates [propionate (IVb), n-butyrate (IVc) and benzoate (IVd)] were synthesized from prednisolone by a sequence of reactions, which involved 21-hydroxymethylation, acylation and rearra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e97e5bf3957251285f0d782b360e61
https://doi.org/10.1016/s0039-128x(68)80076-5

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