Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Mikiharu Yoshida"'
3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain
Autor:
Yuki Ogasawara, Hideo Kimura, Norihiro Shibuya, Kazuyuki Ishii, Mikiharu Yoshida, Tadayasu Togawa, Makiko Tanaka
Publikováno v:
Antioxidants & Redox Signaling. 11:703-714
Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant. Currently, pyridoxal-5'-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain. We recently found that
Publikováno v:
Muscle & Nerve. 32:563-576
The original sarcoglycan (SG) complex has four subunits and comprises a subcomplex of the dystrophin-dystrophin-associated protein complex. Each SG gene has been shown to be responsible for limb-girdle muscular dystrophy, called sarcoglycanopathy (SG
Publikováno v:
Human Molecular Genetics. 13:693-702
An intracellular protein, dystrophin, plays an important role in keeping muscle fibers intact by binding at its N-terminal end to the subsarcolemmal cytoskeletal actin network and via its C-terminal end to the transmembraneous protein beta-dystroglyc
Autor:
Eriko Wakabayashi-Takai, Mikiharu Yoshida, Kiyotoshi Kaneko, Yuji Mizuno, Naomi Takagoshi, Yukiko Yoshimoto-Matsuda, Satoru Noguchi, Kenji Araishi, Hiroshi Hama, Ikuya Nonaka, Eijiro Ozawa, Toshikuni Sasaoka, Michihiro Imamura
Publikováno v:
Neuromuscular Disorders. 13:193-206
While calf muscle hypertrophy is a striking diagnostic finding in sarcoglycanopathy, as it is in Duchenne and Becker muscular dystrophies, its pathogenetic mechanism remains unknown. γ-Sarcoglycan, one of the subunits of the sarcoglycan complex, is
Autor:
Eijiro Ozawa, Yuji Mizuno, Mikiharu Yoshida, Hiroshi Hama, Satoru Noguchi, Michihiro Imamura, Kenji Araishi, Toshikuni Sasaoka, Michiko Ishikawa-Sakurai, Eriko Wakabayashi-Takai
Publikováno v:
Human Molecular Genetics. 9:1033-1040
The sarcoglycan complex is composed of four membrane-spanning dystrophin-associated proteins (DAPs) and is essential for skeletal muscle survival, since the absence or markedly reduced expression of this complex due to mutation of any one of the sarc
Publikováno v:
European Journal of Biochemistry. 267:640-648
The sarcoglycan complex consists of four transmembrane protein subunits. Mutation of any one of the genes encoding these four subunits causes complete loss or marked decrease in expression of the whole complex, resulting in the phenotype of Duchenne-
Publikováno v:
Biochemical and Biophysical Research Communications. 262:88-93
The sarcoglycan complex consists of four membrane-spanning proteins and was shown to be exclusively distributed in striated muscles. In this study, we analyzed the pattern of expression of the mRNAs and proteins of the sarcoglycan subunits during cel
Publikováno v:
Molecular and Cellular Biochemistry. 190:143-151
In 1958 Professor Setsuro Ebashi found that serum creatine kinase activity is increased in patients suffering from various muscular dystrophies, especially Duchenne muscular dystrophy (DMD). He and others proposed that creatine kinase passes through
Publikováno v:
Muscle & Nerve. 21:421-438
Duchenne and Becker muscular dystrophies are collectively termed dystrophinopathy. Dystrophinopathy and severe childhood autosomal recessive muscular dystrophy (SCARMD) are clinically very similar and had not been distinguished in the early 20th cent
Autor:
Andrew H. Ahn, Eijiro Ozawa, Emanuela Gussoni, Chris A. Freener, Louis M. Kunkel, Mikiharu Yoshida
Publikováno v:
Journal of Biological Chemistry. 271:2724-2730
The syntrophins are a biochemically heterogeneous group of 58-kDa intracellular membrane-associated dystrophin-binding proteins. We have cloned and characterized human acidic (alpha 1-) syntrophin and a second isoform of human basic (beta 2-) syntrop