Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mikie Hinata"'
Autor:
Atsushi Nakamura, Hiroko Ono, Azusa Ando, Mikie Hinata, Kazuki Niidome, Shigeki Omachi, Gaku Sakaguchi, Shunji Shinohara
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 9-17 (2017)
We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC mo
Externí odkaz:
https://doaj.org/article/46245ec94f2840988654d3441227fa84
Autor:
Narumi Horita, Daiki Nagamatsu, Yasuhide Morioka, Miki Tanimura, Gaku Sakaguchi, Azusa Nozu, Yasuyoshi Iso, Toshiyuki Kanemasa, Natsue Yamanada, Mikie Hinata, Toshiyuki Asaki, Masayuki Imai, Hidetoshi Matsuda, Kenji Takaya, Osamu Yoshida, Hiromi Nakai, Akira Yukimasa, Shinji Suzuki, Masahiko Soga, Naoki Tsuno, Tomoyuki Ogawa, Hiroki Yamaguchi, Miyuki Yamamoto, Satoko Funaki, Motohiro Fujiu
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2177-2190
A novel series of (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives were identified as selective transient receptor potential vanilloid 4 (TRPV4) channel antagonist and showed analgesic effect in Freund's Complete Adjuvant (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa29140063fa0c3811b33e5cee9b2d9e
https://doi.org/10.1016/j.bmc.2017.02.047
https://doi.org/10.1016/j.bmc.2017.02.047
Autor:
Gaku Sakaguchi, Tetsuji Ito, Naoki Tsuno, Mikie Hinata, Akira Yukimasa, Yasuyoshi Iso, Satoko Funaki, Daiki Nagamatsu, Miki Tanimura, Miyuki Yamamoto, Tatsuhiko Ueno, Toshiyuki Kanemasa, Yoko Nishimura, Masahiko Soga, Natsue Yamanada, Yasuhide Morioka, Osamu Yoshida, Narumi Horita, Masayuki Imai, Takatsugu Inoue, Yusuke Ichihashi, Hiroki Yamaguchi, Hidetoshi Matsuda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4930-4935
A novel series of 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives were found by high throughput screening of the TRPV4 receptor, at which these compounds showed competitive antagonist potential against 4α-phorbol 12,13-didecanoate (4αPDD) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dfca53a6691693d86f5736a65ec6f2
https://doi.org/10.1016/j.bmcl.2016.09.013
https://doi.org/10.1016/j.bmcl.2016.09.013
Autor:
Masabumi Minami, Masayuki Imai, Minoru Hasegawa, Gaku Sakaguchi, Takeshi Yoshioka, Narumi Horita, Atsushi Morita, Junji Tsuchida, Yasuhide Morioka, Mikie Hinata, Kenichi Higashino, Shoji Yamane, Isao Fukuda, Masahiko Soga, Takao Sanaki, Minoru Ikeda, Toshiyuki Kanemasa, Miyuki Yamamoto, Sunao Imai
Publikováno v:
Pain. 159(5)
Transient receptor potential vanilloid 4 (TRPV4) receptor modulates pain, and this has been noted in several animal models. However, the involvement of TRPV4 in osteoarthritic (OA) pain remains poorly understood. This study assessed the functional ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd117c6492d9838952d160f17582672e
https://pubmed.ncbi.nlm.nih.gov/29438227
https://pubmed.ncbi.nlm.nih.gov/29438227
Autor:
Hiroko Ono, Shigeki Omachi, Atsushi Nakamura, Azusa Ando, Kazuki Niidome, Mikie Hinata, Gaku Sakaguchi, Shunji Shinohara
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 9-17 (2017)
We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7016ec3665f0d022cebb9cbe2419d2d
Autor:
Mikie Hinata, Toshiyuki Asaki, Miyuki Yamamoto, Azusa Nozu, Osamu Yoshida, Masayuki Imai, Gaku Sakaguchi, Satoko Funaki, Kenji Takaya, Yasuyoshi Iso, Narumi Horita, Akira Yukimasa, Shinji Suzuki, Naoki Tsuno, Hidetoshi Matsuda, Masahiko Soga, Toshiyuki Kanemasa, Daiki Nagamatsu, Motohiro Fujiu, Hiromi Nakai, Yasuhide Morioka, Hiroki Yamaguchi, Yoko Nishimura, Tetsuji Ito, Tomoyuki Ogawa
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(20)
A series of 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives have been identified as selective TRPV4 antagonists that display inhibition potencies against 4α-phorbol 12,13-didecanoate (4αPDD), well known as a TRPV4 selective agonist and/or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07851f926e3ee62eead1648e33994ed6
https://pubmed.ncbi.nlm.nih.gov/27634196
https://pubmed.ncbi.nlm.nih.gov/27634196
Autor:
Mikie Hinata, Sunao Imai, Takao Sanaki, Junji Tsuchida, Takeshi Yoshioka, Kenichi Higashino, Miyuki Yamamoto, Masayuki Imai, Masahiko Soga, Narumi Horita, Isao Fukuda, Minoru Ikeda, Shoji Yamane, Atsushi Morita, Toshiyuki Kanemasa, Gaku Sakaguchi, Minoru Hasegawa, Masabumi Minami, Yasuhide Morioka, Hinata, Mikie
Publikováno v:
PAIN; May2018, Vol. 159 Issue 5, p939-947, 9p