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Functional Expression of Choline Transporter-Like Protein 1 in LNCaP Prostate Cancer Cells: A Novel Molecular Target

Autor: Masato Inazu, Iwao Saiki, Hiroyuki Uchino, Tsuyoshi Yamanaka, Miki Yara

Publikováno v: Biomolecules & Therapeutics

Prostate cancer is one of the most common cancers in men. Choline PET or PET/CT has been used to visualize prostate cancer, and high levels of choline accumulation have been observed in tumors. However, the uptake system for choline and the functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc7569ae23f3da7df7e7fc33a80b612
https://pubmed.ncbi.nlm.nih.gov/31693854

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Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations—Protective Effects of the Oxygen Radical Scavenger Edaravone

Autor: Kuroda Masahiko, Masato Inazu, Yukihiko Ogiwara, Fredrik Sjövall, Naomi Hara, Miki Yara, Eskil Elmér, Miyuki Chijiiwa, Yusuke Ishida, Michael Karlsson, Hiroyuki Uchino

Publikováno v: Shock. 44:578-584

The pathophysiology of sepsis-associated encephalopathy (SAE) is complex and remains incompletely elucidated. Dysregulated reactive oxygen species (ROS) production and mitochondrial-mediated necrotic-apoptotic pathway have been proposed as part of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fa72d681f9ed9df12136bad3d3d867
https://doi.org/10.1097/shk.0000000000000465

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Functional expression of choline transporter like-protein 1 (CTL1) and CTL2 in human brain microvascular endothelial cells

Autor: Naomi Hara, Takeshi Inoue, Tsuyoshi Yamanaka, Hiroshi Nishihara, Yuiko Kawai, Miki Yara, Beniko Iwao, Masato Inazu

Publikováno v: Neurochemistry international. 93

In this study, we examined the molecular and functional characterization of choline transporter in human brain microvascular endothelial cells (hBMECs). Choline uptake into hBMECs was a saturable process that was mediated by a Na(+)-independent, memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4173c5b2d0a1d30aad9c59937673bd
https://pubmed.ncbi.nlm.nih.gov/26746385

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[Pathophysiology and mechanisms of postoperative cognitive dysfunction]

Autor: Hiroyuki, Uchino, Fumiaki, Nagashima, Ryota, Nishiyama, Yuhsuke, Ishida, Iwao, Saiki, Miki, Yara, Naomi, Hara

Publikováno v: Masui. The Japanese journal of anesthesiology. 63(11)

Postoperative cognitive impairment is a recognized clinical phenomenon. Previously, such clinical findings were called "adverse cerebral effects of anesthesia on old people". POCD is transient disturbance that can affect patients of any age but is mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5918fdc8b3ddc0996ada0f7cade65f44
https://pubmed.ncbi.nlm.nih.gov/25731051

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[Perioperative management of off-pump CABG for a 93-year-old man]

Autor: Miki, Yara, Mikiko, Tomino, Kazuto, Miyata, Yusuke, Ishida, Iwao, Saiki, Nayuko, Seta, Naomi, Hara, Hiroyuki, Uchino

Publikováno v: Masui. The Japanese journal of anesthesiology. 63(10)

In recent years, the aging population has been growing, and the operative techniques and anesthetic methods have advanced. With these developments and medical support, the number of operations on very elderly patients has been increasing. We report t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75d3471554a0183675c6ddedefd07ee1
https://pubmed.ncbi.nlm.nih.gov/25693348

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Molecular and functional characterization of choline transporter in the human trophoblastic cell line JEG-3 cells

Autor: Naomi Hara, Tsuyoshi Yamanaka, Miki Yara, Beniko Iwao, Masato Inazu, Hiroyuki Uchino

Publikováno v: Placenta. 36(6)

Introduction Choline is essential for the synthesis of the major membrane phospholipid phosphatidylcholine (PC), the methyl donor betaine and the neurotransmitter acetylcholine (ACh), which is involved in several vital biological functions that play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bdef86b35af69e279dd5b9b6ad21f8
https://pubmed.ncbi.nlm.nih.gov/25896522

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Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs

Autor: Miki Yara, Masato Inazu, Chiaki Taguchi, Naomi Hara, Iwao Saiki, Hiroyuki Uchino, Tsuyoshi Yamanaka

Publikováno v: Biochemical pharmacology. 88(3)

Positron emission tomography (PET) and PET/computed tomography (PET-CT) studies with (11)C- or (18)F-labeled choline derivatives are used for PET imaging in glioblastoma patients. However, the nature of the choline transport system in glioblastoma is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9c6221b93263f103a6a3f934b71832
https://pubmed.ncbi.nlm.nih.gov/24530235

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