Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Miki S. Park"'
Autor:
Md Tariqul Haque Tuhin, Dengpan Liang, Fang Liu, Hala Aldawod, Toufiq Ul Amin, Joshua S. Ho, Rasha Emara, Arjun D. Patel, Melanie A. Felmlee, Miki S. Park, James A. Uchizono, Mamoun M. Alhamadsheh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The current peripherally acting mu-opioid receptor antagonists present limited permeability and pharmacokinetic properties. Here, the authors develop a drug delivery approach based on AG10, which demonstrates the impact of mu-opioid receptors in the
Externí odkaz:
https://doaj.org/article/037a1740dc7d45b48c812f08d236c015
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101121-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Rutaecarpine is reported as a potent inducer of CYP1A2 enzyme in rats. There are natural herbal supplements containing rutaecarpine that are designed to enhance the CYP1A2-dependent removal of caffeine from blood so that people can have coffee later
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849be7005cb2237581215edf8c5e6e77
http://www.sciencedirect.com/science/article/pii/S2405580821002156
http://www.sciencedirect.com/science/article/pii/S2405580821002156
Publikováno v:
J Med Chem
Protein drugs hold great promise as therapeutics for a wide range of diseases. Unfortunately, one of the greatest challenges to be addressed during clinical development of protein therapeutics is their short circulation half-life. Several protein con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd71a98d77a770d5a835199e7e60bd6
https://europepmc.org/articles/PMC9625839/
https://europepmc.org/articles/PMC9625839/
Autor:
Fang Liu, Wabel Albusairi, Mark R. Miller, Miki S. Park, Arindom Pal, Toufiq Ul Amin, Jesika S. Faridi, Hyun Joo, Elizabeth A. Wilson, Mamoun M. Alhamadsheh, Dengpan Liang, Tariqul Haque Tuhin
Publikováno v:
Molecular Pharmaceutics. 16:3237-3252
[Image: see text] The hydrophobicity of many chemotherapeutic agents usually results in their nonselective passive distribution into healthy cells and organs causing collateral toxicity. Ligand-targeted drugs (LTDs) are a promising class of targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bdab472af26027f84a665307585106
https://doi.org/10.1021/acs.molpharmaceut.9b00432
https://doi.org/10.1021/acs.molpharmaceut.9b00432
Autor:
Isabella A. Graef, Jonathan Fox, Mark Miller, Miki S. Park, Arindom Pal, Jared Khan, William K. Chan, Uma Sinha, Hyun Joo, Mamoun M. Alhamadsheh, Wabel Albusairi, Dengpan Liang, Fang Liu, Neil Kumar, Raghavendra Jampala, Robert Zamboni, Beverly Pappas, Tariqul Haque Tuhin, Marjon Faaij
Publikováno v:
Journal of Medicinal Chemistry. 61:7862-7876
Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a fatal disease with no available disease-modifying therapies. While pathogenic TTR mutations (TTRm) destabilize TTR tetramers, the T119M variant stabilizes TTRm and prevents disease. A comparis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068b9c0a321ccdf9f68abc7b1ad5f8a3
https://doi.org/10.1021/acs.jmedchem.8b00817
https://doi.org/10.1021/acs.jmedchem.8b00817
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::316102c8c8af3b24e5e906750518f804
https://doi.org/10.1096/fasebj.2019.33.1_supplement.672.9
https://doi.org/10.1096/fasebj.2019.33.1_supplement.672.9
Publikováno v:
Protein Expression and Purification. 122:72-81
The aryl hydrocarbon receptor (AHR) is a transcription factor which activates gene transcription by binding to its corresponding enhancer as the heterodimer, which is consisted of AHR and the aryl hydrocarbon receptor nuclear translocator (ARNT). Hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84948d92a550991c19bbef23d4ac328a
https://doi.org/10.1016/j.pep.2016.02.011
https://doi.org/10.1016/j.pep.2016.02.011
Autor:
Miki S. Park, Jin Dong
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 124
Roberts and Rowland explained the well-stirred model as an extreme case of the dispersion model when the dispersion number is infinity. However, the inconsistency within and discrepancy between the theoretical explanation and experimental observation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8faa08a8a642467306ade6fb458d8bf
https://pubmed.ncbi.nlm.nih.gov/30102979
https://pubmed.ncbi.nlm.nih.gov/30102979
Publikováno v:
Biochemical Pharmacology. 88:253-265
The aryl hydrocarbon receptor (AhR) heterodimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) for transcriptional regulation. We generated three N-terminal deletion constructs of the human AhR of 12–24 KDa in size – namely D1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91022c4632e40b3ed9bd2997e6d4aef
https://doi.org/10.1016/j.bcp.2014.01.021
https://doi.org/10.1016/j.bcp.2014.01.021
Publikováno v:
Archives of Drug Information. 4:1-9
INTRODUCTION: Studies using MDCKII and LLC-PK1 cells transfected with MDR1 cDNA indicate that ciprofloxacin is not a substrate of P-glycoprotein. However, our data has shown that transport studies done using different P-gp overexpressing cell lines (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f8bdc6800968ed4f33b1903b46d496d
https://doi.org/10.1111/j.1753-5174.2010.00032.x
https://doi.org/10.1111/j.1753-5174.2010.00032.x