Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Miki Okada-Iwabu"'
Autor:
Toshiko Kobori, Masato Iwabu, Miki Okada-Iwabu, Nozomi Ohuchi, Akiko Kikuchi, Naoko Yamauchi, Takashi Kadowaki, Toshimasa Yamauchi, Masato Kasuga
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Obesity is among the risk factors for male infertility. Although several mechanisms underlying obesity-induced male subfertility have been reported, the entire mechanism of obesity-induced male infertility still remains unclear. Here, we sho
Externí odkaz:
https://doaj.org/article/980144e9922a485586a6f32de5e24f43
Autor:
Jungyoon Ohn, Kyung Wook Been, Jin Yong Kim, Eun Ju Kim, Taeyong Park, Hye‐Jin Yoon, Jeong Seok Ji, Miki Okada‐Iwabu, Masato Iwabu, Toshimasa Yamauchi, Yeon Kyung Kim, Chaok Seok, Ohsang Kwon, Kyu Han Kim, Hyung Ho Lee, Jin Ho Chung
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp 1-14 (2021)
Abstract Alopecia induced by aging or side effects of medications affects millions of people worldwide and impairs the quality of life; however, there is a limit to the current medications. Here, we identify a small transdermally deliverable 5‐mer
Externí odkaz:
https://doaj.org/article/d6bf644462584914a020a0581a8f0c76
Autor:
Masato Iwabu, Miki Okada-Iwabu, Hiroaki Tanabe, Nozomi Ohuchi, Keiko Miyata, Toshiko Kobori, Sara Odawara, Yuri Kadowaki, Shigeyuki Yokoyama, Toshimasa Yamauchi, Takashi Kadowaki
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Masato Iwabu and Miki Okada-Iwabu et al. investigate whether diabetic phenotypes associated with disruption of the adiponectin receptor (AdipoR1) can be reversed in diabetic mice by upregulation of the receptor. They show that overexpressing human Ad
Externí odkaz:
https://doaj.org/article/ad41c15cf5f34d4ca0ec35d04c2cab1e
Autor:
Hiroyuki Futatsugi, Masato Iwabu, Miki Okada-Iwabu, Koh Okamoto, Yosuke Amano, Yutaka Morizaki, Takashi Kadowaki, Toshimasa Yamauchi
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Since December 2019, coronavirus disease 2019 (COVID-19) caused by a novel coronavirus has spread all over the world affecting tens of millions of people. Another pandemic affecting the modern world, type 2 diabetes mellitus is among the major risk f
Externí odkaz:
https://doaj.org/article/f0aa54921026453193573d7c060a9738
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
The number of patients with obesity continues to increase seriously worldwide. It has become clear that, against a background of insulin resistance, obesity induces the so-called metabolic syndrome consisting of diabetes, hypertension, and dyslipidem
Externí odkaz:
https://doaj.org/article/8e1fed3a4dd14df6956ff894275a2920
Publikováno v:
Diabetes & Metabolism Journal, Vol 39, Iss 5, Pp 363-372 (2015)
Obesity associated with unhealthy diet and lack of exercise is shown to contribute to the onset and/or aggravation of the metabolic syndrome and diabetes, thus placing affected individuals at increased risk of cardiovascular disease and cancer. Plasm
Externí odkaz:
https://doaj.org/article/7d9d38f7e5844a44aef722a0891915da
Autor:
Hironori Waki, Masahiro Nakamura, Toshimasa Yamauchi, Ken-ichi Wakabayashi, Jing Yu, Lisa Hirose-Yotsuya, Kazumi Take, Wei Sun, Masato Iwabu, Miki Okada-Iwabu, Takanori Fujita, Tomohisa Aoyama, Shuichi Tsutsumi, Kohjiro Ueki, Tatsuhiko Kodama, Juro Sakai, Hiroyuki Aburatani, Takashi Kadowaki
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002311 (2011)
Identification of regulatory elements within the genome is crucial for understanding the mechanisms that govern cell type-specific gene expression. We generated genome-wide maps of open chromatin sites in 3T3-L1 adipocytes (on day 0 and day 8 of diff
Externí odkaz:
https://doaj.org/article/0c990b46b7104724bce99b5076a4f7f2
Publikováno v:
Endocrine Journal. 69:1-8
While it is well recognized that exercise represents a radical preventive and therapeutic measure for lifestyle-related diseases, it is clear that contemporary lifestyles abound with situations where exercise may be found difficult to implement on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e23840a0d2c52d5c2b394a9edb74d2b
https://doi.org/10.1507/endocrj.ej21-0294
https://doi.org/10.1507/endocrj.ej21-0294
Autor:
Natsumi Iki, Yoshihiro Miwa, Yoshihisa Ikeda, Yuichi Obata, Yoshikazu Hasegawa, Elzeftawy Abdelaziz Elsayed Ibrahim, Hoai Thu Le, Toshiaki Nakashiba, Ken-ichi Yagami, Satoru Takahashi, Kenichi Nakashima, Saori Mizuno-Iijima, Miki Okada-Iwabu, Seiya Mizuno, Miyuki Ishida, Atsuo Ogura, Kazuya Murata, Masato Iwabu, Yoko Daitoku, Tra Thi Huong Dinh, Yoko Tanimoto, Yuko Hamada, Hayate Suzuki, Shinya Ayabe, Fumihiro Sugiyama, Atsushi Yoshiki, Michito Hamada, Shogo Matoba, Kanako Kato
Publikováno v:
Methods. 191:23-31
Genetically modified mouse models are essential for in vivo investigation of gene function and human disease research. Targeted mutations can be introduced into mouse embryos using genome editing technology such as CRISPR-Cas. Although mice with smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d2498906d11f89c2561301d0689c02
https://tsukuba.repo.nii.ac.jp/records/2004113
https://tsukuba.repo.nii.ac.jp/records/2004113
Autor:
Hiroaki Tanabe, Masato Iwabu, Shigeyuki Yokoyama, Masaki Yamamoto, Takaho Terada, Junken Aoki, Miki Okada-Iwabu, Tomomi Kimura-Someya, Yoshihiro Nakamura, Takashi Kadowaki, Hiroki Kawana, Toshimasa Yamauchi, Kuniyuki Kano, Mikako Shirouzu, Yoshifumi Fujii, Yoshiaki Kawano, Masakatsu Hato
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
The human adiponectin receptors, AdipoR1 and AdipoR2, are key anti-diabetic molecules. We previously reported the crystal structures of human AdipoR1 and AdipoR2, revealing that their seven transmembrane helices form an internal closed cavity (the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a433cf99d438c269f70a6d742d60fc6
https://doi.org/10.1038/s42003-020-01160-4
https://doi.org/10.1038/s42003-020-01160-4