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Akademický článek

Antagonizing microRNA‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice

Autor: Hanna Taipaleenmäki, Hiroaki Saito, Saskia Schröder, Miki Maeda, Ramona Mettler, Matthias Ring, Ewa Rollmann, Andreas Gasser, Carl Haasper, Thorsten Gehrke, Alexander Weiss, Steffen K Grimm, Eric Hesse

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 11, Pp 1-21 (2022)

Abstract Postmenopausal bone loss often leads to osteoporosis and fragility fractures. Bone mass can be increased by the first 34 amino acids of human parathyroid hormone (PTH), parathyroid hormone‐related protein (PTHrP), or by a monoclonal antibo

Externí odkaz: https://doaj.org/article/6b2bd7a624ee47c1ace021806a3a7089

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Akademický článek

TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

Autor: Hiroaki Saito, Andreas Gasser, Simona Bolamperti, Miki Maeda, Levi Matthies, Katharina Jähn, Courtney L. Long, Hartmut Schlüter, Marcel Kwiatkowski, Vaibhav Saini, Paola Divieti Pajevic, Teresita Bellido, Andre J. van Wijnen, Khalid S. Mohammad, Theresa A. Guise, Hanna Taipaleenmäki, Eric Hesse

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation i

Externí odkaz: https://doaj.org/article/e1b46a452798403ebde7a78a57d3c849

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TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

Autor: Vaibhav Saini, Khalid S. Mohammad, Levi Matthies, Courtney L. Long, Hiroaki Saito, Andre J. van Wijnen, Simona Bolamperti, Hartmut Schlüter, Miki Maeda, Marcel Kwiatkowski, Paola Divieti Pajevic, Andreas Gasser, Katharina Jähn, Hanna Taipaleenmaki, Theresa A. Guise, Teresita Bellido, Eric Hesse

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

Osteoporosis is caused by increased bone resorption and decreased bone formation. Intermittent administration of a fragment of Parathyroid hormone (PTH) activates osteoblast-mediated bone formation and is used in patients with severe osteoporosis. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d3b30c9f2c001adc480a0d925edf3c
http://link.springer.com/article/10.1038/s41467-019-08778-x

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Akademický článek

Investigação e controle de epidemia de escabiose: uma experiência educativa em aldeia indígena Investigation and control of scabies epidemics: an educative experience in an indigene village

Autor: Sonia Maria Lofredo, Cândida Bernadete de Oliveira, Douglas Rodrigues, Isabel Maria Teixeira Bicudo Pereira, Solange Miki Maeda

Publikováno v: Saúde e Sociedade, Vol 10, Iss 1, Pp 65-86 (2001)

Este trabalho refere-se ao controle de uma epidemia de escabiose em aldeia da tribo Panará, localizada no Xingu, Estado do Mato Grosso, Brasil. Descreve as dificuldades encontradas, decorrentes das diferenças culturais entre os investigadores e a p

Externí odkaz: https://doaj.org/article/e56b80bd0cf44ffbab20ddb17f2ccf7f

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Synthesis of Tetramic Acid Derivatives via a Tandem Umpolung Alkylation/Reduction/Cyclization Reaction of γ-Hydrazono β-Ketoester

Autor: Kiho Imoto, Miki Maeda, Makoto Shimizu, Isao Mizota

Publikováno v: Organic letters. 22(8)

An efficient method for the one-pot synthesis of tetramic acid derivatives was developed utilizing tandem umpolung N-alkylation/reduction/cyclization of γ-hydrazono β-ketoester. By using this reaction as a key step, the total synthesis of the 3-spi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73d8408247b1876a88f866572cd6e32
https://pubmed.ncbi.nlm.nih.gov/32227901

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Increased levels of sodium chloride directly increase osteoclastic differentiation and resorption in mice and men

Autor: Hanna Taipaleenmäki, Frank Feyerabend, L. Wu, Regine Willumeit-Römer, Bérengère J.C. Luthringer, Ziyang Zhang, Eric Hesse, Miki Maeda, Hans Günther Machens, Arndt F. Schilling

Publikováno v: Osteoporosis International
Wu, L.; Luthringer, B.J.C.; Feyerabend, F.; Zhang, Z.; Machens, H.G.; Maeda, M.; Taipaleenmaeki, H.; Hesse, E.; Willumeit-Roemer, R.; Schilling, A.F.: Increased levels of sodium chloride directly increase osteoclastic differentiation and resorption in mice and men. In: Osteoporosis International. Vol. 28 (2017) 11, 3215-3228. (DOI: /10.1007/s00198-017-4163-4)

Summary To better understand the association between high salt intake and osteoporosis, we investigated the effect of sodium chloride (NaCl) on mice and human osteoclastogenesis. The results suggest a direct, activating role of NaCl supplementation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56fc5f1ebc7640100e95a1e578be5ba
http://europepmc.org/articles/PMC5635092

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Responses of grain filling in spring wheat and temperate-zone rice to temperature: Similarities and differences

Autor: Masao Ohnishi, Miki Maeda, Tomoyuki Tanaka, Jairo A. Palta, Müjde Koç, Tohru Kobata, Celaleddin Barutçular

Wheat (Triticum aestivum L.) and rice (Oryza sativa L.), which belong to the Poaceae family, are starch-grain crops, but wheat is adapted to cooler temperature conditions than rice. In this study, the difference between the two contrasting crops in g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c44b3c175baf46d68eec7db22d351b4
https://hdl.handle.net/20.500.12605/19594

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A disulfide bond replacement strategy enables the efficient design of artificial therapeutic peptides

Autor: Keiichi Ohya, Yohei Okada, Kazuhiro Aoki, Takashi Nakae, Miki Maeda, Kazuhiro Chiba

Publikováno v: Tetrahedron. 70:7774-7779

We demonstrate that disulfide bond replacement is an efficient strategy for engineering therapeutic peptides. In previous work, short peptide fragments, known as WP9QY, with sequence homology with the predicted ligand contact surface of the receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2af620ef33bd2095baf9c28a180e6127
https://doi.org/10.1016/j.tet.2014.05.079

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