Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Miki Katoh"'
Publikováno v:
Xenobiotica. 51:1400-1407
Despite the prevalence of laboratory animals such as monkeys, rats, and mice in clinical drug trials, we know little regarding the oxidation of regorafenib in these test subjects. This study aimed to elucidate species differences in the kinetics of r
Publikováno v:
Biopharmaceuticsdrug dispositionREFERENCES. 43(5)
Valproic acid (VPA) is well-known as a histone deacetylase (HDAC) inhibitor. It has been reported that HDAC inhibitors enhance basal and aryl hydrocarbon receptor (AhR) ligand-induced aryl hydrocarbon receptor-responsive gene expression. Other studie
Publikováno v:
Biologicalpharmaceutical bulletin. 45(4)
Single-walled carbon nanotubes (SWCNTs) are made from rolled single graphene sheets with a diameter in the nanometer range and are potential carriers for drug delivery systems. However, their effects on uridine 5'-diphosphate-glucuronosyltransferase
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 52(2)
Regorafenib is glucuronidated mainly by uridine 5'-diphosphate glucuronosyltransferase (UGT) 1A9 in humans. UGT1A9 and its orthologues are expressed in the liver, small intestine, and kidney in humans and laboratory animals. The aim of this study was
1. Cytochrome P450 2J2 (CYP2J2) shows high expression in extrahepatic tissues, including the heart and kidney and in tumours. Inhibition of CYP2J2 has attracted attention for cancer treatment because it metabolises arachidonic acid (AA) to epoxyeicos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107b762e5136fb3be211d32cc05a96b7
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:103-109
Thylakoid-rich spinach extract is being used as dietary weight-loss supplements in Japan. A recent rat study has suggested that intake of thylakoid-rich spinach extract with dietary oil inhibits dietary fat absorption via binding to bile acids, which
Autor:
Junko NAGAOKA, Kanae WADA, Miki KATOH, Naoko FUJITA, Naoto TANAKA, Tomohiro IRISAWA, Sayuri AKUZAWA
Publikováno v:
Food Preservation Science. 45:85-93
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:275-279
Single-walled carbon nanotubes (SWCNTs) are made from a rolled single sheet of graphene with a diameter in the nanometer range. SWCNTs are potential carriers for drug delivery systems because antibodies or drugs can be loaded on their surface; howeve
Publikováno v:
Xenobiotica. 49:270-275
Sulfotransferase (SULT) has been found in the brain; however, the details of its function remain unclear. The present study aimed to elucidate the regional differences in the expression of SULT1 and SULT2 mRNA and SULT activities in the eight functio
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:1754-1758
Uridine 5'-diphosphate-glucuronosyltransferase (UGT) is expressed in the liver and extrahepatic tissues. One of the major metabolic pathways of β-estradiol (E2) is glucuronidation at the 17-hydroxy position by UGTs. This study was performed to deter