Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Miki Hara"'
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 205-209 (2022)
Chaperone-mediated autophagy (CMA) is a unique proteolytic pathway, in which cytoplasmic proteins recognized by HSPA8/Hsc70 (heat shock protein 8) are transported into lysosomes for degradation. LAMP2A (lysosomal-associated membrane protein 2A) recru
Externí odkaz:
https://doaj.org/article/0403bdb1e17d47d1a55f0df69dd752a5
Autor:
Katarzyna A Podyma-Inoue, Miki Hara-Yokoyama, Tamayuki Shinomura, Tomoko Kimura, Masaki Yanagishita
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32351 (2012)
BACKGROUND: Heparan sulfate proteoglycans (HSPGs) are one of the basic constituents of plasma membranes. Specific molecular interactions between HSPGs and a number of extracellular ligands have been reported. Mechanisms involved in controlling the lo
Externí odkaz:
https://doaj.org/article/eee2d64d02734219af6627139495d288
Autor:
Liping Zeng, D. Scott Herdman, Sung Min Lee, Ailin Tao, Manasi Das, Samuel Bertin, Lars Eckmann, Sushil Mahata, Panyisha Wu, Miki Hara, Ji-Won Byun, Shwetha Devulapalli, Hemal H. Patel, Anthony J.A. Molina, Olivia Osborn, Maripat Corr, Eyal Raz, Nicholas J.G. Webster
Publikováno v:
Diabetes.
In obesity, CD11c+ innate immune cells are recruited to adipose tissue and create an inflammatory state that causes both insulin and catecholamine resistance. We found that ablation of Gnas, the gene that encodes Gαs, in CD11c expressing cells prote
Autor:
Nicholas J.G. Webster, Eyal Raz, Maripat Corr, Olivia Osborn, Anthony J.A. Molina, Hemal H. Patel, Shwetha Devulapalli, Ji-Won Byun, Miki Hara, Panyisha Wu, Sushil Mahata, Lars Eckmann, Samuel Bertin, Manasi Das, Ailin Tao, Sung Min Lee, D. Scott Herdman, Liping Zeng
In obesity, CD11c+ innate immune cells are recruited to adipose tissue and create an inflammatory state that causes both insulin and catecholamine resistance. We found that ablation of Gnas, the gene that encodes Gas, in CD11c expressing cells protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e2b7ac01b347fb16578b3edd89e440
https://doi.org/10.2337/figshare.23151608.v1
https://doi.org/10.2337/figshare.23151608.v1
Autor:
Kazue Terasawa, Takanori Iwata, Yuri Tomabechi, Tetsuro Watabe, Mutsuko Kukimoto-Niino, Yuta Ikami, Shigeyuki Yokoyama, Kazumasa Ohtake, Toshihide Kobayashi, Miki Hara-Yokoyama, Kensaku Sakamoto, Mikako Shirouzu, Jun-Lin Guan, Seisuke Kusano, Yuji Kato
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
LAMP1 (lysosomal-associated membrane protein 1) and LAMP2 are the most abundant protein components of lysosome membranes. Both LAMPs have common structures consisting of a large lumenal domain composed of two domains (N-domain and C-domain, which are
Autor:
Yuta Ikami, Kazue Terasawa, Kensaku Sakamoto, Kazumasa Ohtake, Hiroyuki Harada, Tetsuro Watabe, Shigeyuki Yokoyama, Miki Hara-Yokoyama
Publikováno v:
Experimental Cell Research. 411:112986
Chaperone-mediated autophagy (CMA) is a unique proteolytic pathway, in which cytoplasmic proteins recognized by heat shock cognate protein 70 (Hsc70/HSPA8) are transported into lysosomes for degradation. The substrate/chaperone complex binds to the c
Autor:
Tetsuro Watabe, Kazue Terasawa, Miki Hara-Yokoyama, Jin-ichi Inokuchi, Yuichi Izumi, Toshihide Kobayashi, Takashi Ode, Katarzyna A. Podyma-Inoue
Publikováno v:
Experimental Cell Research. 350:103-114
Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism, and cell differentiation. Recent studies have revealed that the recruitment of mTORC1 to lysosomes is essential for its activation. The
Autor:
Kazuhisa Iwabuchi, Katarzyna A. Podyma-Inoue, Hidetake Kurihara, Shozo Ichinose, Norihiro Tada, Chihiro Iwahara, Koichi Furukawa, Miki Hara-Yokoyama, Shizuko Ichinose, Kazue Terasawa, Hironori Matsuda, Masaru Kurosawa
Publikováno v:
J Histochem Cytochem
The arrangement of immature germ cells changes regularly and periodically along the axis of the seminiferous tubule, and is used to describe the progression of spermatogenesis. This description is based primarily on the changes in the acrosome and th
Autor:
Tetsuya Yoda, Tohru Ikeda, Kei Sakamoto, Hiroyuki Harada, Kou Kayamori, Tetsuro Watabe, Maiko Tsuchiya, Daisuke Yamamoto, Miki Hara-Yokoyama
Publikováno v:
Cancer Science
Claudins are the major component of tight junctions, which form a primary barrier to paracellular diffusion and maintain cell polarity in normal epithelia and endothelia. In cancer cells, claudins play additional roles besides serving as components o
Autor:
Hironobu Maezaki, Maki Miyamoto, Miki Hara, Norio Tada, Hisashi Fujita, Junya Shirai, Katsuhiko Miwa, Nobuki Sakauchi, Haruhiko Kuno, Nagako Kameoka, Ayumu Sato, Hideki Furukawa
Publikováno v:
Tetrahedron. 72:6334-6339
5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride (TAK-259) is a novel, selective, and orally active α1D adrenoceptor antagonist with anti-urinary frequency effect. A metabolite (2) of TAK-259 was