Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mikhaila A Smith"'
Autor:
Amber Korn, Laurens F. Reeskamp, Lars E. Larsen, Adriaan G. Holleboom, Mikhaila A Smith, Deepti Abbey, Nicholas J. Hand
Publikováno v:
Atherosclerosis. 303
Dyslipidemias are strongly linked to the development of atherosclerotic cardiovascular disease. Most dyslipidemias find their origin in the liver. In recent years, the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cel
Autor:
Mikhaila A Smith, Christopher D. Brown, Daniel J. Rader, Nicholas J. Hand, Andrea M Berrido, Robert C. Bauer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Single nucleotide polymorphisms (SNPs) in the human 8q24 locus have repeatedly been associated by genome-wide association studies (GWAS) with multiple human metabolic traits such as plasma lipids and coronary artery disease. These SNPs lie in a non-c
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Tribbles-1 (TRIB1) was recently identified through genome-wide association studies as a novel mediator of plasma lipids and coronary artery disease in humans. While subsequent in vivo mouse work confirmed a role for hepatic TRIB1 in these association
Autor:
Robert C Bauer, Xuan Zhang, Junichiro Tohyama, Jian Cui, Mikhaila A Smith, Kristy Ou, X. Long Zheng, Michael S Parmacek, Daniel J Rader, Muredach P Reilly
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
ADAMTS7 has recently been identified as a novel genomic locus associated with coronary artery disease (CAD) in humans. We have recently shown that deficiency of Adamts7 in hyperlipidemic mouse models reduces atherosclerosis following prolonged wester
Autor:
Robert C Bauer, Makoto Sasaki, Daniel M Cohen, Jian Cui, Mikhaila A Smith, David J Steger, Daniel J Rader
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Tribbles1 (TRIB1) was recently identified in genome-wide association studies as being associated with plasma levels of VLDL, HDL, LDL, and TG as well as coronary artery disease in humans. Here we report studies in a Trib1 liver-specific knockout mous
Autor:
Makoto Sasaki, Mikhaila A Smith, Batuhan Yenilmez, Daniel J. Rader, David J. Steger, Robert C. Bauer, Jian Cui, Daniel M. Cohen
Publikováno v:
The Journal of clinical investigation. 125(10)
Variants near the gene TRIB1 are significantly associated with several plasma lipid traits, circulating liver enzymes, and the development of coronary artery disease in humans; however, it is not clear how its protein product tribbles-1 regulates lip
Autor:
Valeska Redon, Donna M. Conlon, Rexford S. Ahima, Batuhan Yenilmez, Stephen L. Sturley, Sean O’Neill, Wen Lin, Miao Wang, William R. Lagor, Rajat Gupta, Daniel J. Rader, Fumin Tong, Kelsey E Jarrett, Mikhaila A Smith, David W Fields, Mary G. McCoy, Arthi Kumaravel, Jeffrey T. Billheimer
Publikováno v:
Nutrition & Diabetes
Background: ACAT-related enzyme 2 required for viability 1 (ARV1) is a putative lipid transporter of the endoplasmic reticulum that is conserved across eukaryotic species. The ARV1 protein contains a conserved N-terminal cytosolic zinc ribbon motif k