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of 254
pro vyhledávání: '"Mikhail V. Blagosklonny"'
Autor:
Mikhail V. Blagosklonny
Publikováno v:
Oncotarget. 14:342-350
Autor:
Mikhail V, Blagosklonny
Publikováno v:
Oncoscience. 9:38-41
Autor:
Tammi L. Kaeberlein, Alan S. Green, George Haddad, Johnny Hudson, Anar Isman, Andy Nyquist, Bradley S. Rosen, Yousin Suh, Sajad Zalzala, Xingyu Zhang, Mikhail V. Blagosklonny, Jonathan Y. An, Matt Kaeberlein
Publikováno v:
GeroScience.
Autor:
Mikhail V. Blagosklonny
Publikováno v:
Aging.
Autor:
Mikhail V, Blagosklonny
Publikováno v:
Oncoscience. 9:13-16
Some visionaries prefer to dream of immortality rather than to actually live longer. Here I discuss how combining rapamycin with other modalities may let us live long enough to benefit from future discoveries in cellular reprogramming and what needs
Autor:
Mikhail V, Blagosklonny
Publikováno v:
Cell Cycle. 21:1456-1467
A hallmark of cellular senescence is proliferation-like activity of growth-promoting pathways (such as mTOR and MAPK) in non-proliferating cells. When the cell cycle is arrested, these pathways convert arrest to senescence (geroconversion), rendering
Autor:
Mikhail V, Blagosklonny
Publikováno v:
Oncoscience
Although average human life expectancy is rising, the maximum lifespan is not increasing. Leading demographers claim that human lifespan is fixed at a natural limit around 122 years. However, there is no fixed limit in animals. In animals, anti-aging
Autor:
Mikhail V. Blagosklonny
Publikováno v:
Oncoscience
Autor:
Mikhail V. Blagosklonny
Publikováno v:
Oncotarget
Senolytics are basically anti-cancer drugs, repurposed to kill senescent cells selectively. It is even more difficult to selectively kill senescent cells than to kill cancer cells. Based on lessons of cancer therapy, here I suggest how to exploit onc