Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Mikhail V, Dubinin"'
Autor:
Natalia V. Belosludtseva, Anna I. Ilzorkina, Dmitriy A. Serov, Mikhail V. Dubinin, Eugeny Yu. Talanov, Maxim N. Karagyaur, Alexandra L. Primak, Jiankang Liu, Konstantin N. Belosludtsev
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1159 (2024)
Hyperlipidemia is a major risk factor for vascular lesions in diabetes mellitus and other metabolic disorders, although its basis remains poorly understood. One of the key pathogenetic events in this condition is mitochondrial dysfunction associated
Externí odkaz:
https://doaj.org/article/5747cef7b535411a90a1341f8fe08898
Autor:
Mikhail V. Dubinin, Anastasia E. Stepanova, Irina B. Mikheeva, Anastasia D. Igoshkina, Alena A. Cherepanova, Eugeny Yu. Talanov, Ekaterina I. Khoroshavina, Konstantin N. Belosludtsev
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9892 (2024)
Duchenne muscular dystrophy is secondarily accompanied by Ca2+ excess in muscle fibers. Part of the Ca2+ accumulates in the mitochondria, contributing to the development of mitochondrial dysfunction and degeneration of muscles. In this work, we asses
Externí odkaz:
https://doaj.org/article/88ca04d30f1740e38f28a74f7e79225d
Autor:
Mikhail V. Dubinin, Irina B. Mikheeva, Anastasia E. Stepanova, Anastasia D. Igoshkina, Alena A. Cherepanova, Alena A. Semenova, Vyacheslav A. Sharapov, Igor I. Kireev, Konstantin N. Belosludtsev
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 316 (2024)
Duchenne muscular dystrophy is caused by loss of the dystrophin protein. This pathology is accompanied by mitochondrial dysfunction contributing to muscle fiber instability. It is known that mitochondria-targeted in vivo therapy mitigates pathology a
Externí odkaz:
https://doaj.org/article/5147bebf625f44df8404ef6370119d83
Autor:
Mikhail V. Dubinin, Anna I. Ilzorkina, Elena V. Salimova, Manish S. Landage, Ekaterina I. Khoroshavina, Sergey V. Gudkov, Konstantin N. Belosludtsev, Lyudmila V. Parfenova
Publikováno v:
Membranes, Vol 13, Iss 10, p 835 (2023)
The paper assesses the membranotropic action of the natural antibiotic fusidic acid (FA) and its derivatives. It was found that a FA analogue with ethylenediamine moiety (derivative 2), in contrast to native FA and 3,11-dioxime analogue (derivative 1
Externí odkaz:
https://doaj.org/article/cfe549a4c290421195912f0c234c1bfb
Autor:
Konstantin N. Belosludtsev, Dmitriy A. Serov, Anna I. Ilzorkina, Vlada S. Starinets, Mikhail V. Dubinin, Eugeny Yu. Talanov, Maxim N. Karagyaur, Alexandra L. Primak, Natalia V. Belosludtseva
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1459 (2023)
Prolonged hyperglycemia related to diabetes and its complications leads to multiple cellular disorders, the central one being the dysfunction of mitochondria. Voltage-dependent anion channels (VDAC) of the outer mitochondrial membrane control the met
Externí odkaz:
https://doaj.org/article/5d2b4a23e9a645d48b646ffa2ba393ee
Autor:
Mikhail V. Dubinin, Darya A. Nedopekina, Anna I. Ilzorkina, Alena A. Semenova, Vyacheslav A. Sharapov, Eldar V. Davletshin, Natalia V. Mikina, Yuri P. Belsky, Anna Yu. Spivak, Vladimir S. Akatov, Natalia V. Belosludtseva, Jiankang Liu, Konstantin N. Belosludtsev
Publikováno v:
Membranes, Vol 13, Iss 6, p 563 (2023)
The present work shows the cytotoxic effects of novel conjugates of ursolic, oleanolic, maslinic, and corosolic acids with the penetrating cation F16 on cancer cells (lung adenocarcinoma A549 and H1299, breast cancer cell lines MCF-7 and BT474) and n
Externí odkaz:
https://doaj.org/article/e339fd2e58c7473da384490b7ffb9826
Autor:
Victor N. Samartsev, Ekaterina I. Khoroshavina, Evgeniya K. Pavlova, Mikhail V. Dubinin, Alena A. Semenova
Publikováno v:
Membranes, Vol 13, Iss 5, p 472 (2023)
It is now generally accepted that the role of bile acids in the organism is not limited to their participation in the process of food digestion. Indeed, bile acids are signaling molecules and being amphiphilic compounds, are also capable of modifying
Externí odkaz:
https://doaj.org/article/6580ab385ecb461d9200c9ea46e56c0b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2229 (2023)
Duchenne muscular dystrophy (DMD) is caused by the absence of the dystrophin protein and a properly functioning dystrophin-associated protein complex (DAPC) in muscle cells. DAPC components act as molecular scaffolds coordinating the assembly of vari
Externí odkaz:
https://doaj.org/article/8ee94c1e32644e97be0dc55ae02e5026
Autor:
Konstantin N. Belosludtsev, Anna I. Ilzorkina, Natalia V. Belosludtseva, Vyacheslav A. Sharapov, Nikita V. Penkov, Dmitriy A. Serov, Maxim N. Karagyaur, Darya A. Nedopekina, Eldar V. Davletshin, Marina E. Solovieva, Anna Yu Spivak, Ulyana Sh. Kuzmina, Yulia V. Vakhitova, Vladimir S. Akatov, Mikhail V. Dubinin
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2903 (2022)
The present study evaluates the cytotoxicity of a previously synthesized conjugate of betulinic acid (BA) with the penetrating cation F16 on breast adenocarcinoma (MCF-7) and human fibroblast (HF) cell lines, and also shows the mechanism underlying i
Externí odkaz:
https://doaj.org/article/d8db71920aa640569f976a059a164c58
Autor:
Mikhail V. Dubinin, Vlada S. Starinets, Natalia V. Belosludtseva, Irina B. Mikheeva, Yuliya A. Chelyadnikova, Anastasia D. Igoshkina, Aliya B. Vafina, Alexander A. Vedernikov, Konstantin N. Belosludtsev
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2336 (2022)
Duchenne muscular dystrophy (DMD) is a progressive hereditary disease caused by the absence of the dystrophin protein. This is secondarily accompanied by a dysregulation of ion homeostasis, in which mitochondria play an important role. In the present
Externí odkaz:
https://doaj.org/article/e93518515f044b948f94f3645308f5b8