A Spontaneous Inversion of the X Chromosome Heterochromatin Provides a Tool for Studying the Structure and Activity of the Nucleolus in Drosophila melanogaster

Autor: Tatyana D. Kolesnikova, Mikhail S. Klenov, Alina R. Nokhova, Sergey A. Lavrov, Galina V. Pokholkova, Veit Schubert, Svetlana V. Maltseva, Kevin R. Cook, Michael J. Dixon, Igor F. Zhimulev

Publikováno v: Cells, Vol 11, Iss 23, p 3872 (2022)

The pericentromeric heterochromatin is largely composed of repetitive sequences, making it difficult to analyze with standard molecular biological methods. At the same time, it carries many functional elements with poorly understood mechanisms of act

Externí odkaz: https://doaj.org/article/28d5d1f998b04041b4a142e3d5c7af32

Long Noncoding RNAs and Stress Response in the Nucleolus

Autor: Sergei A. Pirogov, Vladimir A. Gvozdev, Mikhail S. Klenov

Publikováno v: Cells, Vol 8, Iss 7, p 668 (2019)

Long noncoding RNAs (lncRNAs) perform diverse functions in the regulation of cellular processes. Here we consider a variety of lncRNAs found in the ribosome production center, the nucleolus, and focus on their role in the response to environmental st

Externí odkaz: https://doaj.org/article/e4a8be1f2d364848b97c887636073fdb

Special vulnerability of somatic niche cells to transposable element activation in Drosophila larval ovaries

Autor: Yuri Abramov, Mikhail S. Klenov, Elena A. Mikhaleva, O. A. Sokolova, Vladimir A. Gvozdev, Sergey L. Kharitonov

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports

In the Drosophila ovary, somatic escort cells (ECs) form a niche that promotes differentiation of germline stem cell (GSC) progeny. The piRNA (Piwi-interacting RNA) pathway, which represses transposable elements (TEs), is required in ECs to prevent t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bf088499b1392afd75e5f495b92f1c
http://link.springer.com/article/10.1038/s41598-020-57901-2

Complex Genetic Interactions between Piwi and HP1a in the Repression of Transposable Elements and Tissue-Specific Genes in the Ovarian Germline

Autor: Artem A. Ilyin, Anastasia D. Stolyarenko, Nikolay Zenkin, Mikhail S. Klenov

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13430
International Journal of Molecular Sciences, Vol 22, Iss 13430, p 13430 (2021)

Insertions of transposable elements (TEs) in eukaryotic genomes are usually associated with repressive chromatin, which spreads to neighbouring genomic sequences. In ovaries of Drosophila melanogaster, the Piwi-piRNA pathway plays a key role in the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91361ec80bf662b581b2e4da1daf440e
http://europepmc.org/articles/PMC8707237

Role of Udd protein and heterochromatin in transcriptional selection of individual rRNA genes in theDrosophilagermline

Autor: Yuri Abramov, Roman S. Blokh, Valentin A. Poltorachenko, Mikhail S. Klenov, Elena A. Mikhaleva, Daniil D. Romashin, Elena Fefelova, Vladimir A. Gvozdev, Irina M. Pleshakova, Sergei A. Pirogov

Eukaryotic genomes contain hundreds of nearly identical rRNA genes, many of which are transcriptionally silent. However, the mechanisms of selective regulation of individual rDNA units remain poorly understood. InDrosophila melanogaster, rDNA repeats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2c15ed6ea89525f0db9eaa069a454f4
https://doi.org/10.1101/2020.10.21.349613