Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Mikhail Pashenkov"'
Serotonergic drug repurposing in multiple sclerosis: A new possibility for disease-modifying therapy
Autor:
Mikhail Melnikov, Dmitriy Kasatkin, Anna Lopatina, Nikolay Spirin, Alexey Boyko, Mikhail Pashenkov
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Investigation of neuroimmune interactions is one of the most developing areas in the study of multiple sclerosis pathogenesis. Recent evidence suggests the possibility of modulating neuroinflammation by targeting biogenic amine receptors. It has been
Externí odkaz:
https://doaj.org/article/cb7d26303e7c4ee8b40717062a7cedb7
Autor:
Mikhail Melnikov, Vladimir Rogovskii, Anastasiya Sviridova, Anna Lopatina, Mikhail Pashenkov, Alexey Boyko
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 668 (2022)
Norepinephrine is a neurotransmitter that also has an immunomodulatory effect and is involved in multiple sclerosis (MS) pathogenesis. This study aimed to clarify the role of the β2-adrenoreceptor in the norepinephrine-mediated modulation of interle
Externí odkaz:
https://doaj.org/article/98fd06560b884e55947cd6f26371c082
Autor:
Mikhail Melnikov, Svetlana Sharanova, Anastasiya Sviridova, Vladimir Rogovskii, Nina Murugina, Anna Nikolaeva, Yulia Dagil, Vladimir Murugin, Tatiana Ospelnikova, Alexey Boyko, Mikhail Pashenkov
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240305 (2020)
Glatiramer acetate (GA) is approved for the treatment of multiple sclerosis (MS). However, the mechanism of action of GA in MS is still unclear. In particular, it is not known whether GA can modulate the pro-inflammatory Th17-type immune response in
Externí odkaz:
https://doaj.org/article/faa5b240c1da436eb10222a7f1b195a2
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5313 (2021)
Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which
Externí odkaz:
https://doaj.org/article/80b6ce63ed8249c1b76c5aad89080f78
Autor:
Mikhail Pashenkov, M V Melnikov, Vladimir V. Murugin, Vladimir Rogovskii, Anastasiya Sviridova, Alexey Boyko, Vladimir Kudrin
Publikováno v:
Current Neuropharmacology. 20:1632-1639
Background: Dopamine is one of the main mediators capable regulate the neuroimmune interaction and is involved in multiple sclerosis (MS) pathogenesis. Methods: 34 relapsing-remitting MS patients and 23 healthy subjects were examined. To assess the e
Publikováno v:
International immunopharmacology. 114
Neutrophils release extracellular traps (NETs) in response to numerous pathogenic microbes as the last suicidal resource (NETosis) in the fight against infection. Apart from the host defense function, NETs play an essential role in the pathogenesis o
Autor:
Vladimir V. Murugin, Nina E. Murugina, Boris V. Pinegin, Viktoriya S. Sharova, Anna M. Nikolaeva, Polina Maximchik, Anna S. Budikhina, Georgy Z. Chkadua, Mikhail Pashenkov, Lyudmila S. Balyasova, M V Melnikov, Yulia A. Dagil
Publikováno v:
J Biol Chem
Upon activation with pathogen-associated molecular patterns, metabolism of macrophages and dendritic cells is shifted from oxidative phosphorylation to aerobic glycolysis, which is considered important for proinflammatory cytokine production. Fragmen
Autor:
V. M. Ukrainskaya, Denis Y. Logunov, Alexandra V. Maleeva, O. Ivanova, Inna V. Dolzhikova, Grigory A. Efimov, Iuliia O. Peshkova, Leila Ovchinnikova, Elizaveta Romanova, Savely A. Sheetikov, Alexandra Gracheva, Ksenia V. Zornikova, Alexander Mitin, Ioanna N. Filimonova, Anna Tvorogova, Alexey A. Komissarov, Nelli B. Naigovzina, Anna Navoikova, Mikhail Pashenkov, Yakov A. Lomakin, Liudmila Shevkova, Aleksander Deryabin, Anna Panova, D. Vorobyeva, E. Maryukhnich, N. Pinegina, Yury P. Rubtsov, Denis Lagutkin, Musa Khaitov, Viktoria Komogorova, Yana Serdyuk, Oksana Musatova, Walaa Asaad, Irina Vasilyeva, Anastasia Samoilova, Vladimir Murugin, Afraa Mohammad, Pavel Volchkov, Anatoliy Vinokurov, Daria Potashnikova, Natalia Kompantseva, Ivan Molodtsov, Anastasia Kizilova, Evgenii Kegeles, Nawar Sakr, Anna Trufanova, Alexander Shpektor, Elena Vasilieva, Aleena Saidova, Olga Mityaeva, Nina Murugina, Naina T. Shakirova, Nina Sharova, Anastasia Komova, Ilya Kofiadi, Anastasia Shemetova, Anna Budikhina, Margarita Nikonova, Alsalloum Almaqdad
Background Coronavirus disease COVID-19 has spread worldwide extremely rapidly. Although many individuals have been infected and have cleared the virus, developing virus-specific antibodies and effector/memory T cells, an important question still to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ad609d16d6841d8058374892924746a
https://doi.org/10.1101/2021.08.19.21262278
https://doi.org/10.1101/2021.08.19.21262278
Autor:
Mikhail, Melnikov, Anastasiya, Sviridova, Vladimir, Rogovskii, Vladimir, Kudrin, Vladimir, Murugin, Alexey, Boyko, Mikhail, Pashenkov
Publikováno v:
Current neuropharmacology. 20(8)
Dopamine is one of the main mediators capable regulate the neuroimmune interaction and is involved in multiple sclerosis (MS) pathogenesis.The aim of this study was to clarify the role of dopamine and its receptors in modulation of Th17-cells in MS.3
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5313, p 5313 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 5313, p 5313 (2021)
Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which