Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

Autor: Morteza Chalabi Hajkarim, Ella Karjalainen, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Grønbæk, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won

Publikováno v: eLife, Vol 11 (2022)

Large-scale multiparameter screening has become increasingly feasible and straightforward to perform thanks to developments in technologies such as high-content microscopy and high-throughput flow cytometry. The automated toolkits for analyzing simil

Externí odkaz: https://doaj.org/article/3f675683279247e3902e4a69cb12b59a

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

Autor: Abdellatif Benraiss, Su Wang, Stephanie Herrlinger, Xiaojie Li, Devin Chandler-Militello, Joseph Mauceri, Hayley B. Burm, Michael Toner, Mikhail Osipovitch, Qiwu Jim Xu, Fengfei Ding, Fushun Wang, Ning Kang, Jian Kang, Paul C. Curtin, Daniela Brunner, Martha S. Windrem, Ignacio Munoz-Sanjuan, Maiken Nedergaard, Steven A. Goldman

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The contribution of glia to Huntington's disease is unclear. The authors show that human glial progenitor cells (GPCs) expressing mutant huntingtin impair motor performance when engrafted into wild type mice, and wild type human GPCs ameliorate disea

Externí odkaz: https://doaj.org/article/1efcf5bbea644ef3ac2340ad9aa2efda

Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

Autor: Ella Karjalainen, Morteza Chalabi Hajkarim, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Grønbæk, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won

Publikováno v: Chalabi Hajkarim, M, Karjalainen, E, Osipovitch, M, Dimopoulos, K, Gordon, S L, Ambri, F, Rasmussen, K D, Grønbæk, K, Helin, K, Wennerberg, K & Won, K-J 2022, ' Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models ', eLife, vol. 11, e73760 . https://doi.org/10.7554/eLife.73760

Large-scale multiparameter screening has become increasingly feasible and straightforward to perform thanks to developments in technologies such as high-content microscopy and high-throughput flow cytometry. The automated toolkits for analyzing simil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7a199d9f50566a99a89ca2b875725a
https://curis.ku.dk/portal/da/publications/comprehensive-and-unbiased-multiparameter-highthroughput-screening-by-compare-finds-effective-and-subtle-drug-responses-in-aml-models(e0f96da2-3ced-4480-acad-eabd0e85cb66).html

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease

Autor: Martha S. Windrem, Mikhail Osipovitch, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman, Carlos Benitez Villanueva, John N. Mariani, Adam Cornwell

Publikováno v: Benraiss, A, Mariani, J N, Osipovitch, M, Cornwell, A, Windrem, M S, Villanueva, C B, Chandler-Militello, D & Goldman, S A 2021, ' Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease ', Cell Reports, vol. 36, no. 1, 109308 . https://doi.org/10.1016/j.celrep.2021.109308

Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206d15dbfad3f84e0ea8f4d27df81c8
https://curis.ku.dk/portal/da/publications/cellintrinsic-glial-pathology-is-conserved-across-human-and-murine-models-of-huntingtons-disease(c3ca9d6a-32a3-4218-8682-ce9366a925d3).html

Automated protein motif generation in the structure-based protein function prediction tool ProMOL

Autor: Cameron Baker, Paul Craig, Jeffrey Mills, Herbert J. Bernstein, Mitchell Lambrecht, Shariq Madha, Mikhail Osipovitch

Publikováno v: Journal of Structural and Functional Genomics. 16:101-111

ProMOL, a plugin for the PyMOL molecular graphics system, is a structure-based protein function prediction tool. ProMOL includes a set of routines for building motif templates that are used for screening query structures for enzyme active sites. Prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e79fc15bc605c47368b48a0913762d
https://doi.org/10.1007/s10969-015-9199-0