Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mikhail Lebedin"'
Autor:
Mikhail Lebedin, Christoph Ratswohl, Amar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Weiner, 3rd, Ilais Moreno Velásquez, Cathrin Gerhard, Paula Stubbemann, Leif-Gunnar Hanitsch, Tobias Pischon, Martin Witzenrath, Leif Erik Sander, Florian Kurth, Michael Meyer-Hermann, Kathrin de la Rosa
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109330- (2024)
Summary: Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-co
Externí odkaz:
https://doaj.org/article/7c9c5701df2748eb9bb1238451f24137
Publikováno v:
Bio-Protocol, Vol 13, Iss 8 (2023)
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern. In contrast to Cas9 nuclease,
Externí odkaz:
https://doaj.org/article/f12665057d33439795d2811856568a68
Publikováno v:
Open Biology, Vol 11, Iss 1 (2021)
Precision genomic alterations largely rely on homology directed repair (HDR), but targeting without homology using the non-homologous end-joining (NHEJ) pathway has gained attention as a promising alternative. Previous studies demonstrated precise in
Externí odkaz:
https://doaj.org/article/b82c8fa0b53f4079b2dbf5b3b2dc2d5b
Autor:
Mikhail Lebedin, Clara Vázquez García, Lisa Spatt, Christoph Ratswohl, Charlotte Thibeault, Lennard Ostendorf, Tobias Alexander, Friedemann Paul, Leif Erik Sander, Florian Kurth, Kathrin de la Rosa
Publikováno v:
European Journal of Immunology. 53
Autor:
null Mikhail Lebedin, null Clara Vázquez García, null Lisa Spatt, null Christoph Ratswohl, null Charlotte Thibeault, null Lennard Ostendorf, null Tobias Alexander, null Friedemann Paul, null Leif Erik Sander, null Florian Kurth, null Kathrin de la Rosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f5dccda8126f6a3d875704dcc4cdd0
https://doi.org/10.1002/eji.202250210/v2/response1
https://doi.org/10.1002/eji.202250210/v2/response1
Autor:
Mikhail Lebedin, Mathilde Foglierini, Svetlana Khorkova, Clara Vázquez García, Christoph Ratswohl, Alexey N. Davydov, Maria A. Turchaninova, Claudia Daubenberger, Dmitriy M. Chudakov, Antonio Lanzavecchia, Kathrin de la Rosa
Recombination of antibody genes in B cells can involve distant genomic loci and contribute a foreign antigen-binding element to form hybrid antibodies with broad reactivity forPlasmodium falciparum. So far, antibodies containing the extracellular dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a413a4e886ec2790dd1f1f27de8e477
http://edoc.mdc-berlin.de/22049/1/22049oa.pdf
http://edoc.mdc-berlin.de/22049/1/22049oa.pdf
Autor:
Ngoc Tung Tran, Eric Danner, Xun Li, Robin Graf, Mikhail Lebedin, Kathrin de la Rosa, Ralf Kühn, Klaus Rajewsky, Van Trung Chu
While CRISPR-Cas9 is key for the development of gene therapy, its potential off-target mutations are still a major concern. Here, we establish a “spacer-nick” gene correction approach that combines the Cas9 D10A nickase with a pair of PAM-out sgR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b6c659b34f96eb1729858874bbdf53
http://edoc.mdc-berlin.de/21560/2/21560suppl.pdf
http://edoc.mdc-berlin.de/21560/2/21560suppl.pdf
Publikováno v:
Open Biology
Open Biology, Vol 11, Iss 1 (2021)
Open Biology, Vol 11, Iss 1 (2021)
Precision genomic alterations largely rely on Homology Directed Repair (HDR), but targeting without homology using the Non-Homologous End Joining (NHEJ) pathway has gained attention as a promising alternative. Previous studies demonstrated precise in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711b7ca1527b916772c8a8c70938cf98
http://edoc.mdc-berlin.de/19728/1/19728oa.pdf
http://edoc.mdc-berlin.de/19728/1/19728oa.pdf