Výsledky vyhledávání - "Mikhail Hammond"

Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors

Autor: Fiore Cattaruzza, Ayesha Nazeer, Milton To, Mikhail Hammond, Caitlin Koski, Lucas Y. Liu, V. Pete Yeung, Deena A. Rennerfeldt, Angela Henkensiefken, Michael Fox, Sharon Lam, Kari M. Morrissey, Zachary Lange, Vladimir N. Podust, Mika K. Derynck, Bryan A. Irving, Volker Schellenberger

Publikováno v: Nature Cancer. 4:485-501

To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth factor receptor (EGFR)) and CD3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d08fc750f9f56209e1642cb13b83c12b
https://doi.org/10.1038/s43018-023-00536-9

Zobrazit plný text záznamu

Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues

Autor: Yogesh G. Shelke, Kyriacos C. Nicolaou, Aaron Kempema, Balu D. Dherange, Mikhail Hammond, Monette Aujay, Baiwei Lin, Christine Gu, Joseph Sandoval, Julia Gavrilyuk

Publikováno v: The Journal of Organic Chemistry. 85:2865-2917

Despite previous studies within the epothilone field, only one member of this compound family, ixabepilone, made it to approval for clinical use. Recent advances in organic synthesis and medicinal chemistry allow further optimization of lead epothilo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df609dbbcd2b4e504934fba88e05eea6
https://doi.org/10.1021/acs.joc.0c00123

Zobrazit plný text záznamu

Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics

Autor: Julia Gavrilyuk, Mikhail Hammond, Subhrajit Rout, Yong Lu, Monette Aujay, Kyriacos C. Nicolaou, Joseph Sandoval, Emmanuel N. Pitsinos, Dipendu Das, Joseph Lyssikatos, Alexander Schammel

Publikováno v: Journal of the American Chemical Society. 142(5)

The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimyci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b660907f744160d7bf15f85afc7a5cb5
https://pubmed.ncbi.nlm.nih.gov/31976660

Zobrazit plný text záznamu

Abstract P193: AMX-818, a novel prodrug HER2-XPAT T-cell engager (TCE) with potent T cell activation, proteolytic cleavage and efficacy in xenograft tumors, and wide safety margins in NHP (Non Human Primate)

Autor: Milton To, Pete Yeung, Michael Fox, Mikhail Hammond, Fiore Cattaruzza, Ayesha Nazeer, Caitlin Koski, Lucas Liu, Sina Khorsand, Deena Rennerfeldt, Kari Morrissey, Zachary Lange, Ming Dong, Sharon Lam, Mika K. Derynck, Bryan A. Irving, Volker Schellenberger

Publikováno v: Molecular Cancer Therapeutics. 20:P193-P193

Background: TCEs are effective in leukemias, but have been limited in solid tumors due to on-target, off-tumor toxicity. Attempts to circumvent cytokine release syndrome (CRS), including step-up dosing and complex designs, have had limited success du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d602a9bec59360dbc10aa516748d9391
https://doi.org/10.1158/1535-7163.targ-21-p193

Zobrazit plný text záznamu

Abstract 1824: HER2-XPAT, a novel protease-activatable T-cell engager (TCE) with potent T-cell activation and efficacy in solid tumors and large safety margins in non-human primate (NHP)

Autor: Zachary Lange, Bryan Irving, Mika K. Derynck, Volker Schellenberger, Caitlin Koski, Sharon Lam, Milton To, Fiore Cattaruzza, Mikhail Hammond, Ayesha Nazeer, Pete Yeung

Publikováno v: Cancer Research. 81:1824-1824

Background: TCEs are effective in leukemias but have been challenging in solid tumors due to on-target, off-tumor toxicity. Attempts to circumvent cytokine release syndrome (CRS) including step-up dosing and/or complex molecular designs have been uns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e62e0c9f790fb6fd5238d9c43d5471f
https://doi.org/10.1158/1538-7445.am2021-1824

Zobrazit plný text záznamu

Abstract PS17-11: Her2-xpat, a novel protease-activatable prodrug t-cell engager (tce), exhibits potent t-cell activation and efficacy in her2 tumors, yielding large predicted safety margins based on non-human primate (nhp)

Autor: Mikhail Hammond, Ayesha Nazeer, Trang Dao-Pick, Mika K. Derynck, Caitlin Koski, Zachary Lange, Volker Schellenberger, Fiore Cattaruzza, Angela Henkensiefken, Bryan Irving

Publikováno v: Cancer Research. 81:PS17-11

Background TCEs are effective at inducing remissions in hematologic cancers but have been challenging in solid tumors due to on-target, off-tumor toxicity. Attempts to circumvent CRS include fractionated or step-up dosing and/or complex molecular des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46d7d683bff007e98c6fc5c0e2555bad
https://doi.org/10.1158/1538-7445.sabcs20-ps17-11

Zobrazit plný text záznamu

Abstract 3376: HER2-XPAT and EGFR-XPAT: Pro-drug T-cell engagers (TCEs) engineered to address on-target, off-tumor toxicity with potent efficacy in vitro and in vivo and large safety margins in NHP

Autor: Ayesha Nazeer, Fiore Cattaruzza, Zachary Lange, Angela Henkensiefken, Bryan Irving, Mika K. Derynck, Mikhail Hammond, Volker Schellenberger, Caitlin Koski

Publikováno v: Cancer Research. 80:3376-3376

Background: TCEs have proven to be effective in creating durable remissions in hematologic malignancies but have been challenging in solid tumors due to on-target, off-tumor toxicity. To circumvent the toxicity, many have tried step-up, fractionated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d77c267077cbde98e9c5b85a3400c80
https://doi.org/10.1158/1538-7445.am2020-3376

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání