Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Mikhail G, Kolonin"'
Autor:
Eleanor J. McKay, Ineke Luijten, Xiong Weng, Pablo B. Martinez de Morentin, Elvira De Frutos González, Zhanguo Gao, Mikhail G. Kolonin, Lora K. Heisler, Robert K. Semple
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101933- (2024)
Objective: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS
Externí odkaz:
https://doaj.org/article/6169fc3899214b92ba7975f834effd36
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/42fa12628dd947c8899f8912d66b6162
Autor:
Sydney S. Wilbon, Mikhail G. Kolonin
Publikováno v:
Cells, Vol 13, Iss 1, p 65 (2023)
Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients and clinicians in treating type-2 diabetes and obesity. Drugs of this class, the bioavailability of which is continuously improving, enable weight loss and contr
Externí odkaz:
https://doaj.org/article/797c1e242728478da5b394da9ac07491
The role of the aging microenvironment on the fate of PDGFRβ lineage cells in skeletal muscle repair
Autor:
Aiping Lu, Chieh Tseng, Ping Guo, Zhanguo Gao, Kaitlyn E. Whitney, Mikhail G. Kolonin, Johnny Huard
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Background During aging, perturbation of muscle progenitor cell (MPC) constituents leads to progressive loss of muscle mass and accumulation of adipose and fibrotic tissue. Mesenchymal stem cells (MSCs) give rise to adipocytes and fibroblast
Externí odkaz:
https://doaj.org/article/3b1b7a739f9844119cb513bb085ef0cf
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101544- (2022)
Objective: Brown adipogenesis and thermogenesis in brown and beige adipose tissue (AT) involve vascular remodeling and sympathetic neuronal guidance. Here, we investigated the molecular mechanism coordinating these processes. Methods: We used mouse m
Externí odkaz:
https://doaj.org/article/06ee3167ca6d45f8883c4d427024a6cf
Autor:
Aleix Ribas-Latre, Rafael Bravo Santos, Baharan Fekry, Yomna M. Tamim, Samay Shivshankar, Alaa M. T. Mohamed, Corrine Baumgartner, Christopher Kwok, Claudia Gebhardt, Angielyn Rivera, Zhanguo Gao, Kai Sun, John T. Heiker, Brad E. Snyder, Mikhail G. Kolonin, Kristin L. Eckel-Mahan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
During the expansion of adipose tissue adipocyte progenitor cells proliferate and undergo adipogenesis. Here, the authors show that adipocyte progenitor cell proliferation in visceral adipose tissue has a diurnal pattern, which is dependent on both e
Externí odkaz:
https://doaj.org/article/d2bcdacfb8da49f1947d4b6f3b07213c
Autor:
Fei Su, Alexes C. Daquinag, Songyeon Ahn, Achinto Saha, Yulin Dai, Zhongming Zhao, John DiGiovanni, Mikhail G. Kolonin
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Aggressiveness of carcinomas is linked with tumor recruitment of adipose stromal cells (ASC), which is increased in obesity. ASC promote cancer through molecular pathways not fully understood. Here, we demonstrate that epithelial–mesenchym
Externí odkaz:
https://doaj.org/article/278639b602984827ab52b214507bb321
Autor:
Ayala Tovy, Jaime M Reyes, Linda Zhang, Yung-Hsin Huang, Carina Rosas, Alexes C Daquinag, Anna Guzman, Raghav Ramabadran, Chun-Wei Chen, Tianpeng Gu, Sinjini Gupta, Laura Ortinau, Dongsu Park, Aaron R Cox, Rachel E Rau, Sean M Hartig, Mikhail G Kolonin, Margaret A Goodell
Publikováno v:
eLife, Vol 11 (2022)
DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity and exce
Externí odkaz:
https://doaj.org/article/50aa572dd7974a318da9ef564b060f60
Autor:
Fei Su, Xiaoping Wang, Troy Pearson, Jangsoon Lee, Savitri Krishnamurthy, Naoto T. Ueno, Mikhail G. Kolonin
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 579-586 (2020)
Adipose stromal cells (ASCs) recruited by tumors contribute to the population of cancer-associated fibroblasts. ASCs have been reported to induce tumor growth and chemotherapy resistance. The effect of ASCs on metastasis has not been explored. Here,
Externí odkaz:
https://doaj.org/article/fcb93f3f1b044ee2b2c3c3af04f3a3fb
Publikováno v:
Biology, Vol 11, Iss 12, p 1768 (2022)
Despite progress in biomedical technologies, cardiovascular disease remains the main cause of mortality. This is at least in part because current clinical interventions do not adequately take into account aging as a driver and are hence aimed at subo
Externí odkaz:
https://doaj.org/article/9e4ab42e219c4a27b6878d4999ca800f