Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mikhail Burmakin"'
Autor:
Emmanuelle Charrin, Dina Dabaghie, Ilke Sen, David Unnersjö-Jess, Katja Möller-Hackbarth, Mikhail Burmakin, Rik Mencke, Sonia Zambrano, Jaakko Patrakka, Hannes Olauson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Transgenic overexpression of αKlotho in hepatocytes results in protection against renal insults, possibly through modulation of the ER stress response by circulating αKlotho. In contrast, αKlotho overexpressed in podocytes is not renoprotective.
Externí odkaz:
https://doaj.org/article/619b3e82d9e24b86ae6db800031da9d4
Autor:
Agnieszka Kłosowska-Wardega, Yoko Hasumi, Mikhail Burmakin, Aive Ahgren, Linda Stuhr, Ingrid Moen, Rolf K Reed, Kristofer Rubin, Carina Hellberg, Carl-Henrik Heldin
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8149 (2009)
Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake. Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (
Externí odkaz:
https://doaj.org/article/59cdccc99380471090cc1e6d18009326
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(17)
Autor:
Hanako Kobayashi, Andres A. Urrutia, Volker H. Haase, Fredrik Palm, Angelica Fasching, Mikhail Burmakin, Anastasios E. Damdimopoulos
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 233(1)
Aim Hypoxia-inducible factors (HIFs) are O2 -sensitive transcription factors that regulate multiple biological processes which are essential for cellular adaptation to hypoxia. Small molecule inhibitors of HIF-prolyl hydroxylase domain (PHD) dioxygen
Autor:
Andres A. Urrutia, Malini Rajan, Jiao Liu, Volker H. Haase, Olena Davidoff, Hanako Kobayashi, Mikhail Burmakin, Ken Ishii, Zubaida Saifudeen
Publikováno v:
Kidney International. 92:1370-1383
Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A ke
Autor:
Andrei L. Okorokov, Poroikov, C. Spinnler, Vera V. Grinkevich, Elisabeth Hedström, Perdita E. Barran, Joanna Zawacka-Pankau, Aparna Vema, Natalia Issaeva, Mikhail Burmakin, Alberto Inga, Eleanor R. Dickinson, Maria N. Preobrazhenskaya, Galina Selivanova, Olga Tarasova, S. N. Lavrenov, Fawkner K, Anders Karlén, Lars Larsson, Andreotti
Given the immense significance of p53 restoration for anti-cancer therapy and that p53-activating molecules are in clinical trials, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075188e35e1d954df35a13045e3fc84a
Autor:
Galina Selivanova, S. N. Lavrenov, C. Spinnler, Vera V. Grinkevich, Natalia Issaeva, Alberto Inga, Margareta Wilhelm, Eleanor R. Dickinson, Karin Ridderstråle, Maria N. Preobrazhenskaya, Andrei L. Okorokov, Joanna Zawacka-Pankau, Olga Tarasova, Virginia Andreotti, Mikhail Burmakin, Perdita E. Barran, Aparna Vema, Anders Karlén, Elisabeth Hedström, Vladimir Poroikov, Lars-Gunnar Larsson
Publikováno v:
SSRN Electronic Journal.
Given the immense significance of p53 restoration for anti-cancer therapy, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a discovery of a novel allosteric modulation of p53 by small mo
Autor:
Aive Åhgren, Linda Elin Birkhaug Stuhr, P. Olof Olsson, Carina Hellberg, Rolf K. Reed, Mikhail Burmakin, Tijs van Wieringen, Kristofer Rubin, Carl-Henrik Heldin
Publikováno v:
Journal of Translational Medicine
Background: Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft mode
Publikováno v:
Clinical Cancer Research. 19:5092-5103
Purpose: Restoration of the p53 function in tumors is a promising therapeutic strategy due to the high potential of p53 as tumor suppressor and the fact that established tumors depend on p53 inactivation for their survival. Here, we addressed the que
Autor:
Carina Hellberg, Agnieszka Kłosowska-Wardęga, Rolf K. Reed, Yoko Hasumi, Aive Åhgren, Linda Elin Birkhaug Stuhr, Kristofer Rubin, Ingrid Moen, Carl-Henrik Heldin, Mikhail Burmakin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 12, p e8149 (2009)
PLoS ONE, Vol 4, Iss 12, p e8149 (2009)
Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake. Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (