How to change the oligomeric state of a circular protein assembly: switch from 11-subunit to 12-subunit TRAP suggests a general mechanism.

Autor: Chao-Sheng Chen, Callum Smits, Guy G Dodson, Mikhail B Shevtsov, Natalie Merlino, Paul Gollnick, Alfred A Antson

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25296 (2011)

Many critical cellular functions are performed by multisubunit circular protein oligomers whose internal geometry has evolved to meet functional requirements. The subunit number is arguably the most critical parameter of a circular protein assembly,

Externí odkaz: https://doaj.org/article/f7801003277d4445899bdce6414be90e

Crystal structure of semi-synthetic obelin-v after calcium induced bioluminescence implies coelenteramine as the main reaction product

Autor: Pavel V. Natashin, Elena V. Eremeeva, Mikhail B. Shevtsov, Margarita I. Kovaleva, Sergey S. Bukhdruker, Daria A. Dmitrieva, Dmitry V. Gulnov, Elena V. Nemtseva, Valentin I. Gordeliy, Alexey V. Mishin, Valentin I. Borshchevskiy, Eugene S. Vysotski

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Coelenterazine-v (CTZ-v), a synthetic vinylene-bridged π-extended derivative, is able to significantly alter bioluminescence spectra of different CTZ-dependent luciferases and photoproteins by shifting them towards longer wavelengths. Howev

Externí odkaz: https://doaj.org/article/5e569ca5c75d43e5939327cb2a853179

Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions

Autor: Daniil Vakhrameev, Xiaohui Wang, Irina A. Talyzina, Arthur O. Zalevsky, Sergey A. Goncharuk, Mikhail B. Shevtsov, Konstantin S. Mineev, Valentin Borshchevskiy, Vladislav A. Lushpa, Alexander S. Arseniev, Marina V. Goncharuk, Aleksandra Luginina, Cong Lin

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology 4(1), 1003 (2021). doi:10.1038/s42003-021-02532-0
Communications Biology
'Communications Biology ', vol: 4, pages: 1003-1-1003-12 (2021)

Toll-like receptors (TLRs) play an important role in the innate immune response. While a lot is known about the structures of their extracellular parts, many questions are still left unanswered, when the structural basis of TLR activation is analyzed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bddd7624c623c99bd007c466f21ba1
https://doaj.org/article/ba1903b9028f4b788d2c7b76bc761832

Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis

Autor: Alexander S. Apt, R. Astashkin, Konstantin B. Majorov, Vladimir I. Dolgopalets, Aleksandra Luginina, Ivan Maslov, Natallia Strushkevich, Sviatlana Smolskaya, Valentin Gordeliy, Raisa P. Litvinovskaya, Boris Nikonenko, Andrei A. Gilep, Darrell E. Hurt, Anna Kavaleuskaya, Anton Kavaleuski, Polina Shabunya, Tatsiana Varaksa, A. V. Rogachev, Egor Marin, Alex Rosenthal, Yury Charnou, Mikhail B. Shevtsov, Anastasiia Gusach, Valentin Borshchevskiy, Evgeny Shevchenko, Alaksiej L. Hurski, Kirill Kovalev, Sergey Bukhdruker, Dmitrii Zabelskii, Alexander V. Baranovsky, Aleh Savachka, Alexey Mishin, Andrei Gabrielian, Irina Grabovec

Publikováno v: Journal of molecular biology 433(4), 166763-(2021). doi:10.1016/j.jmb.2020.166763

Mycobacterium tuberculosis (Mtb) infection is among top ten causes of death worldwide, and the number of drug-resistant strains is increasing. The direct interception of human immune signaling molecules by Mtb remains elusive, limiting drug discovery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5941fde8889634dd0a0610b952e0f6
https://hdl.handle.net/2128/29692

Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression

Autor: Anna Swiderska, S.J. Thresh, Mikhail B. Shevtsov, Simon Streeter, John McGeehan, Geoff Kneale

Publikováno v: 'Acta Crystallographica D ', vol: 71, pages: 398-407 (2015)
Shevtsov, M B, Streeter, S D, Thresh, S-J, Swiderska, A, Mcgeehan, J E & Kneale, G G 2015, ' Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression ', Acta Crystallographica Section D, vol. 71, no. 2, pp. 398-407 . https://doi.org/10.1107/S139900471402690X
Acta Crystallographica Section D: Biological Crystallography

The structure of the new class of controller proteins (exemplified by C.Csp231I) in complex with its 21 bp DNA-recognition sequence is presented, and the molecular basis of sequence recognition in this class of proteins is discussed. An unusual exten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92780460ac1b38952df0fee9b622f749
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:40928