Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Mikhail A. Shulepko"'
Autor:
Zakhar O. Shenkarev, Yuri M. Chesnokov, Maxim M. Zaigraev, Anton O. Chugunov, Dmitrii S. Kulbatskii, Milita V. Kocharovskaya, Alexander S. Paramonov, Maxim L. Bychkov, Mikhail A. Shulepko, Dmitry E. Nolde, Roman A. Kamyshinsky, Evgeniy O. Yablokov, Alexey S. Ivanov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The membrane plays a key role in the interaction of non-conventional neurotoxins with the nicotinic receptors.
Externí odkaz:
https://doaj.org/article/54654b9e8be64f4eba0aad318a544d08
Autor:
Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Aizek B. Isaev, Ilya D. Kukushkin, Maxim L. Bychkov, Mikhail A. Shulepko, Anton O. Chugunov, Mikhail P. Kirpichnikov
Publikováno v:
Toxins, Vol 15, Iss 10, p 612 (2023)
Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family. The α-ENaC/ASIC1a/γ-ENaC heterotrimeric channel is a tumor-s
Externí odkaz:
https://doaj.org/article/dfc5d92e10344ed5904eaa6a5cb5eb24
Autor:
Ekaterina N. Lyukmanova, Pavel A. Mironov, Dmitrii S. Kulbatskii, Mikhail A. Shulepko, Alexander S. Paramonov, Elizaveta M. Chernaya, Yulia A. Logashina, Yaroslav A. Andreev, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev
Publikováno v:
Toxins, Vol 15, Iss 6, p 378 (2023)
Phα1β (PnTx3–6) is a neurotoxin from the spider Phoneutria nigriventer venom, originally identified as an antagonist of two ion channels involved in nociception: N-type voltage-gated calcium channel (CaV2.2) and TRPA1. In animal models, Phα1β a
Externí odkaz:
https://doaj.org/article/f4d10ab60deb48d7b5091e7ada0f2188
Autor:
Anastasia V. Sudarikova, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Vladislav I. Chubinskiy-Nadezhdin, Olga V. Shlepova, Mikhail A. Shulepko, Sergey G. Koshelev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Lung cancer is one of the most common cancer types in the world. Despite existing treatment strategies, overall patient survival remains low and new targeted therapies are required. Acidification of the tumor microenvironment drives the growth and me
Externí odkaz:
https://doaj.org/article/1790649e29a24969afaa70ad2b6fc156
Autor:
Maxim L. Bychkov, Mikhail A. Shulepko, Olga V. Shlepova, Dmitrii S. Kulbatskii, Irina A. Chulina, Alexander S. Paramonov, Ludmila K. Baidakova, Viatcheslav N. Azev, Sergey G. Koshelev, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev, Ekaterina N. Lyukmanova
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR), participating in control of cancer cell growth. Previously we showed, that a recombin
Externí odkaz:
https://doaj.org/article/4ea1ae5dc8d1418182e8d7e2d15ebd4d
Autor:
Alexander S. Paramonov, Mikhail A. Shulepko, Alexey M. Makhonin, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Andrey M. Chernikov, Mikhail Yu. Myshkin, Sergey V. Shabelnikov, Zakhar O. Shenkarev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 503 (2022)
Three-finger proteins (TFPs) are small proteins with characteristic three-finger β-structural fold stabilized by the system of conserved disulfide bonds. These proteins have been found in organisms from different taxonomic groups and perform various
Externí odkaz:
https://doaj.org/article/c9dc58cc334d4852948d18e54962e1f7
Autor:
Maxim L. Bychkov, Artem V. Kirichenko, Irina N. Mikhaylova, Alexander S. Paramonov, Evgeny V. Yastremsky, Mikhail P. Kirpichnikov, Mikhail A. Shulepko, Ekaterina N. Lyukmanova
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 660 (2022)
Metastatic melanoma is a highly malignant tumor. Melanoma cells release extracellular vesicles (EVs), which contribute to the growth, metastasis, and malignancy of neighboring cells by transfer of tumor-promoting miRNAs, mRNA, and proteins. Melanoma
Externí odkaz:
https://doaj.org/article/3d3334bbbbac4cdf98d941a02d580fc8
Autor:
Mikhail Yu. Myshkin, Roope Männikkö, Olesya A. Krumkacheva, Dmitrii S. Kulbatskii, Anton O. Chugunov, Antonina A. Berkut, Alexander S. Paramonov, Mikhail A. Shulepko, Matvey V. Fedin, Michael G. Hanna, Dimitri M. Kullmann, Elena G. Bagryanskaya, Alexander S. Arseniev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova, Alexander A. Vassilevski, Zakhar O. Shenkarev
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Voltage-gated sodium (NaV) channels are essential for the normal functioning of cardiovascular, muscular, and nervous systems. These channels have modular organization; the central pore domain allows current flow and provides ion selectivity, whereas
Externí odkaz:
https://doaj.org/article/4464bf84a7ef4033a00db58a1fd06aed
Autor:
Maxim L. Bychkov, Artem V. Kirichenko, Mikhail A. Shulepko, Irina N. Mikhaylova, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Biomedicines, Vol 9, Iss 10, p 1324 (2021)
Melanoma is an aggressive cancer characterized by the acidification of the extracellular environment. Here, we showed for the first time that extracellular media acidification increases proliferation, migration, and invasion of patient-derived metast
Externí odkaz:
https://doaj.org/article/7ee50844c4f04ac1afc71ba47f68a752
Autor:
Alexander S. Paramonov, Milita V. Kocharovskaya, Andrey V. Tsarev, Dmitrii S. Kulbatskii, Eugene V. Loktyushov, Mikhail A. Shulepko, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova, Zakhar O. Shenkarev
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7280 (2020)
Ly-6/uPAR or three-finger proteins (TFPs) contain a disulfide-stabilized β-structural core and three protruding loops (fingers). In mammals, TFPs have been found in epithelium and the nervous, endocrine, reproductive, and immune systems. Here, using
Externí odkaz:
https://doaj.org/article/9cd3524cb23c48b1918e62fa48056d1e