Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Mikhail A. Kutuzov"'
Autor:
Maria V. Sukhanova, Rashid O. Anarbaev, Ekaterina A. Maltseva, Mikhail M. Kutuzov, Olga I. Lavrik
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The formation of nuclear biomolecular condensates is often associated with local accumulation of proteins at a site of DNA damage. The key role in the formation of DNA repair foci belongs to PARP1, which is a sensor of DNA damage and catalyz
Externí odkaz:
https://doaj.org/article/4345651c06e44d94a1015d06dede364d
Autor:
Ekaterina A. Maltseva, Inna A. Vasil’eva, Nina A. Moor, Daria V. Kim, Nadezhda S. Dyrkheeva, Mikhail M. Kutuzov, Ivan P. Vokhtantsev, Lilya M. Kulishova, Dmitry O. Zharkov, Olga I. Lavrik
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/551c09fde19346b8adeeea88bf4b74d2
Autor:
Tatyana A. Kurgina, Nina A. Moor, Mikhail M. Kutuzov, Konstantin N. Naumenko, Alexander A. Ukraintsev, Olga I. Lavrik
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Kurgina et al. conduct in vitro characterization of the effect of HPF1 on the catalytic output of PARP1 and PARP2 under several experimental conditions. The authors report that the DNAdependent and DNA-independent autoPARylation of PARP1 and PARP2, a
Externí odkaz:
https://doaj.org/article/e4c35787c23446cd93c6e3d3eff5af73
Autor:
Michael I Barton, Stuart A MacGowan, Mikhail A Kutuzov, Omer Dushek, Geoffrey John Barton, P Anton van der Merwe
Publikováno v:
eLife, Vol 10 (2021)
The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in the RBD are present in SARS-CoV-2 variants of concern that have emerged
Externí odkaz:
https://doaj.org/article/6de5dd278c3443c5b73c853e319f1f0e
Autor:
Johannes Pettmann, Anna Huhn, Enas Abu Shah, Mikhail A Kutuzov, Daniel B Wilson, Michael L Dustin, Simon J Davis, P Anton van der Merwe, Omer Dushek
Publikováno v:
eLife, Vol 10 (2021)
T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) antigens. Although the discriminatory power of the TCR is widely believed
Externí odkaz:
https://doaj.org/article/bcd2f1d193024b08b393a17283f277a4
Autor:
Enas Abu-Shah, Philippos Demetriou, Štefan Bálint, Viveka Mayya, Mikhail A Kutuzov, Omer Dushek, Michael L Dustin
Publikováno v:
eLife, Vol 8 (2019)
Research in the field of human immunology is restricted by the lack of a system that reconstitutes the in-situactivation dynamics of quiescent human antigen-specific T-cells interacting with dendritic cells. Here we report a tissue-like system that r
Externí odkaz:
https://doaj.org/article/7078a64cb83b480cb219dd2e3e856c67
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S23-S23 (2019)
Background: The genome is always exposed to different kinds of DNA damaging agents. DNA repair systems in cells are responsible for the genome integrity. The damages, which do not make strong disturbance of double stranded DNA structure, are normally
Externí odkaz:
https://doaj.org/article/f91fa0f805c24a38b338fbe777be99f4
Autor:
Jesús A. Siller-Farfán, P. Anton van der Merwe, Jake Burton, Mikhail A Kutuzov, Benjamin Salzer, Omer Dushek, Johannes Pettmann
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Chimeric antigen receptors (CARs) can redirect T cells to target abnormal cells, but their activity is limited by a profound defect in antigen sensitivity, the source of which remains unclear. Here, we show that CARs have a > 100-fold lower antigen s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a532f014a3fc14b18c0eb5bb998796
https://doi.org/10.1073/pnas.2216352120
https://doi.org/10.1073/pnas.2216352120
Autor:
Konstantin N. Naumenko, Mariya V. Sukhanova, Loic Hamon, Tatyana A. Kurgina, Elizaveta E. Alemasova, Mikhail M. Kutuzov, David Pastré, Olga I. Lavrik
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1325 (2020)
Y-box-binding protein 1 (YB-1) is a multifunctional positively charged protein that interacts with DNA or RNA and poly(ADP-ribose) (PAR). YB-1 is poly(ADP-ribosyl)ated and stimulates poly(ADP-ribose) polymerase 1 (PARP1) activity. Here, we studied th
Externí odkaz:
https://doaj.org/article/2ccb3ea8872a487e8a10a3dbcc006a74
Autor:
Tatyana A. Kurgina, Stanislav I. Shram, Mikhail M. Kutuzov, Tatyana V. Abramova, Tatyana A. Shcherbakova, Ekaterina A. Maltseva, Vladimir V. Poroikov, Olga I. Lavrik, Vytas K. Švedas, Dmitry K. Nilov
Publikováno v:
Biochemistry. Biokhimiia. 87(8)
Previously, we have found that a nucleic acid metabolite, 7-methylguanine (7mGua), produced in the body can have an inhibitory effect on the poly(ADP-ribose) polymerase 1 (PARP1) enzyme, an important pharmacological target in anticancer therapy. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd583df87f40b7b425803f5d0dc4645
https://pubmed.ncbi.nlm.nih.gov/36171646
https://pubmed.ncbi.nlm.nih.gov/36171646