Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Mikhail A Shulepko"'
Autor:
Aizek B. Isaev, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Alexander A. Andreev-Andrievskiy, Mikhail A. Mashkin, Mikhail A. Shulepko, Olga V. Shlepova, Eugene V. Loktyushov, Alexander V. Latanov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Intellectual disability and autistic features are associated with chromosome region 2q23.q23.2 duplication carrying LYPD6 and LYPD6B genes. Here, we analyzed LYPD6 and LYPD6B expression in patients with different neuropsychiatric disorders.
Externí odkaz:
https://doaj.org/article/2ae1874777974e35a3cdb4490b504935
Autor:
Ekaterina N Lyukmanova, Mikhail A Shulepko, Denis Kudryavtsev, Maxim L Bychkov, Dmitrii S Kulbatskii, Igor E Kasheverov, Maria V Astapova, Alexey V Feofanov, Morten S Thomsen, Jens D Mikkelsen, Zakhar O Shenkarev, Victor I Tsetlin, Dmitry A Dolgikh, Mikhail P Kirpichnikov
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149733 (2016)
SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease Mal de Meleda. SLURP-1 is considered an autocrine/paracrine ho
Externí odkaz:
https://doaj.org/article/83af7a1944694beaa6e9ee97a1f0dfd1
Autor:
Ekaterina N. Lyukmanova, Maxim L. Bychkov, Andrei M. Chernikov, Ilya D. Kukushkin, Dmitrii S. Kulbatskii, Sergey V. Shabelnikov, Mikhail A. Shulepko, Ran Zhao, Wenxiao Guo, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev, Alexander S. Paramonov
Publikováno v:
Marine Drugs, Vol 22, Iss 11, p 488 (2024)
Three-finger proteins (TFPs), or Ly6/uPAR proteins, are characterized by the beta-structural LU domain containing three protruding “fingers” and stabilized by four conserved disulfide bonds. TFPs were initially characterized as snake alpha-neurot
Externí odkaz:
https://doaj.org/article/cbdd90c4476b4696a151b0459a9e1974
Autor:
Zakhar O. Shenkarev, Yuri M. Chesnokov, Maxim M. Zaigraev, Anton O. Chugunov, Dmitrii S. Kulbatskii, Milita V. Kocharovskaya, Alexander S. Paramonov, Maxim L. Bychkov, Mikhail A. Shulepko, Dmitry E. Nolde, Roman A. Kamyshinsky, Evgeniy O. Yablokov, Alexey S. Ivanov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The membrane plays a key role in the interaction of non-conventional neurotoxins with the nicotinic receptors.
Externí odkaz:
https://doaj.org/article/54654b9e8be64f4eba0aad318a544d08
Autor:
Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Aizek B. Isaev, Ilya D. Kukushkin, Maxim L. Bychkov, Mikhail A. Shulepko, Anton O. Chugunov, Mikhail P. Kirpichnikov
Publikováno v:
Toxins, Vol 15, Iss 10, p 612 (2023)
Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family. The α-ENaC/ASIC1a/γ-ENaC heterotrimeric channel is a tumor-s
Externí odkaz:
https://doaj.org/article/dfc5d92e10344ed5904eaa6a5cb5eb24
Autor:
Ekaterina N. Lyukmanova, Pavel A. Mironov, Dmitrii S. Kulbatskii, Mikhail A. Shulepko, Alexander S. Paramonov, Elizaveta M. Chernaya, Yulia A. Logashina, Yaroslav A. Andreev, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev
Publikováno v:
Toxins, Vol 15, Iss 6, p 378 (2023)
Phα1β (PnTx3–6) is a neurotoxin from the spider Phoneutria nigriventer venom, originally identified as an antagonist of two ion channels involved in nociception: N-type voltage-gated calcium channel (CaV2.2) and TRPA1. In animal models, Phα1β a
Externí odkaz:
https://doaj.org/article/f4d10ab60deb48d7b5091e7ada0f2188
Autor:
Anastasia V. Sudarikova, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Vladislav I. Chubinskiy-Nadezhdin, Olga V. Shlepova, Mikhail A. Shulepko, Sergey G. Koshelev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Lung cancer is one of the most common cancer types in the world. Despite existing treatment strategies, overall patient survival remains low and new targeted therapies are required. Acidification of the tumor microenvironment drives the growth and me
Externí odkaz:
https://doaj.org/article/1790649e29a24969afaa70ad2b6fc156
Autor:
Maxim L. Bychkov, Mikhail A. Shulepko, Olga V. Shlepova, Dmitrii S. Kulbatskii, Irina A. Chulina, Alexander S. Paramonov, Ludmila K. Baidakova, Viatcheslav N. Azev, Sergey G. Koshelev, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev, Ekaterina N. Lyukmanova
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR), participating in control of cancer cell growth. Previously we showed, that a recombin
Externí odkaz:
https://doaj.org/article/4ea1ae5dc8d1418182e8d7e2d15ebd4d
Autor:
Alexander S. Paramonov, Mikhail A. Shulepko, Alexey M. Makhonin, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Andrey M. Chernikov, Mikhail Yu. Myshkin, Sergey V. Shabelnikov, Zakhar O. Shenkarev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 503 (2022)
Three-finger proteins (TFPs) are small proteins with characteristic three-finger β-structural fold stabilized by the system of conserved disulfide bonds. These proteins have been found in organisms from different taxonomic groups and perform various
Externí odkaz:
https://doaj.org/article/c9dc58cc334d4852948d18e54962e1f7
Autor:
Maxim L. Bychkov, Artem V. Kirichenko, Mikhail A. Shulepko, Irina N. Mikhaylova, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Biomedicines, Vol 9, Iss 10, p 1324 (2021)
Melanoma is an aggressive cancer characterized by the acidification of the extracellular environment. Here, we showed for the first time that extracellular media acidification increases proliferation, migration, and invasion of patient-derived metast
Externí odkaz:
https://doaj.org/article/7ee50844c4f04ac1afc71ba47f68a752