Zobrazeno 1 - 10
of 444
pro vyhledávání: '"Mikhail, Krasavin"'
Autor:
Mikhail Krasavin, Andrey Bubyrev, Alexander Kazantsev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Dmitry Dar’in, Marcus D. Hartmann, Alexander Bunev
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 527-530 (2022)
The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide glu
Externí odkaz:
https://doaj.org/article/05018ca618a34ca08fb973d138964a14
Autor:
Tatiana Sharonova, Petr Zhmurov, Stanislav Kalinin, Alessio Nocentini, Andrea Angeli, Marta Ferraroni, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 857-865 (2022)
A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing signific
Externí odkaz:
https://doaj.org/article/2a3dc5eb7f254984b17701835310cb94
Autor:
Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1005-1011 (2022)
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II. For all hydrophilic derivatives,
Externí odkaz:
https://doaj.org/article/4bd8215628fd4666b45c04fefe090d2d
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1070-1078 (2022)
A practically convenient and streamlined protocol for the trans-diastereoselective introduction of an aryl substituent at position 4 of the 1,4-dihydroisoquinol-3-one (1,4-DHIQ) scaffold is presented. The protocol involves direct Regitz diazo transfe
Externí odkaz:
https://doaj.org/article/ad00af4c01454a37b5affe0a8c6d42dd
Autor:
Anastasia Vepreva, Alexander S. Bunev, Andrey Yu. Kudinov, Grigory Kantin, Mikhail Krasavin, Dmitry Dar’in
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 533-538 (2022)
Formation of unusual unsymmetrical dimers or/and indenes via Rh2(esp)2-catalyzed decomposition of 3-diazo-2-arylidenesuccinimides has been investigated. The reaction proceeded under mild conditions, and its result was shown to strongly depend on the
Externí odkaz:
https://doaj.org/article/a98ea79958ae430586c51cb837e45a55
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The intracellular redox homeostasis is a dynamic balancing system between the levels of free radical species and antioxidant enzymes and small molecules at the core of cellular defense mechanisms. The thioredoxin (Trx) system is an important detoxifi
Externí odkaz:
https://doaj.org/article/685d5339d4ba4765a62deffdda27ca5e
Autor:
Claudiu T. Supuran, Alessio Nocentini, Elena Yakubova, Nikolay Savchuk, Stanislav Kalinin, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1056-1060 (2021)
The non-nucleoside reverse transcriptase inhibitor VM1500A is approved for the treatment of HIV/AIDS in its N-acyl sulphonamide prodrug form elsulfavirine (Elpida®). Biochemical profiling against twelve human carbonic anhydrase (CA, EC 4.2.1.1) isof
Externí odkaz:
https://doaj.org/article/a5ead323feb1445da0a557ed55629d7f
Autor:
Alexander Safrygin, Petr Zhmurov, Dmitry Dar’in, Sergey Silonov, Mariia Kasatkina, Yulia Zonis, Maxim Gureev, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1916-1921 (2021)
An earlier described three-component variant of the Castagnoli-Cushman reaction employing homophthalic anhydrides, carbonyl compound and ammonium acetate was applied towards the preparation of 1-oxo-3,4-dihydroisoquinoline-4-carboxamides with variabl
Externí odkaz:
https://doaj.org/article/94cbe3267a764eb3b862deda4ce22495
Autor:
Alexey Lukin, Anna Bakholdina, Mikhail Chudinov, Oleksandra Onopchenko, Elena Zhuravel, Sergey Zozulya, Maxim Gureev, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1650-1657 (2021)
A set of 1,3,4-thiadiazole-2-carboxamides bearing a substituted biphenyl in the amide portion was synthesised and tested for agonistic activity towards free fatty acid receptor 1 (FFA1). The observed activity trends were impossible to rationalised ba
Externí odkaz:
https://doaj.org/article/9d3f63a014b74b7099392ec6f9080af1
Autor:
Alexander Safrygin, Petr Zhmurov, Dmitry Dar’in, Sergey Silonov, Mariia Kasatkina, Yulia Zonis, Maxim Gureev, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1968-1983 (2021)
A novel 3,4-dihydroisoquinol-1-one-4-carboxamide scaffold was designed as the basis for the development of novel inhibitors of poly(ADP-ribose) polymerase (PARP). Synthesis of 3,4-dihydroisoquinol-1-one-4-carboxylic acids was achieved using the previ
Externí odkaz:
https://doaj.org/article/a5d24594dad4463bb818fc64b8151896