A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk

Autor: Berthenet, Elvire, Yahara, Koji, Thorell, Kaisa, Pascoe, Ben, Meric, Guillaume, Mikhail, Jane, Engstrand, Lars, Enroth, Helena, Burette, Alain, Megraud, Francis, Varon, Christine, Atherton, John, Smith, Sinead, Wilkinson, Thomas, Hitchings, Matthew, Falush, Daniel, Sheppard, Samuel

Publikováno v: BMC Biology, Vol 16, Iss 1, Pp 1-11 (2018)
BMC Biology
BMC Biology, 2018, 16 (1), pp.84. ⟨10.1186/s12915-018-0550-3⟩
BMC Biology, BioMed Central, 2018, 16 (1), pp.84. ⟨10.1186/s12915-018-0550-3⟩

Background Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gastric cancer. Epidemiologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9e5cf01e578437b59abd0dc05fe5c400
https://orca.cardiff.ac.uk/id/eprint/116512/1/s12915-018-0550-3.pdf

Additional file 5: of A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk

Autor: Berthenet, Elvire, Yahara, Koji, Thorell, Kaisa, Pascoe, Ben, Meric, Guillaume, Mikhail, Jane, Engstrand, Lars, Enroth, Helena, Burette, Alain, Megraud, Francis, Varon, Christine, Atherton, John, Sinead Smith, Wilkinson, Thomas, Hitchings, Matthew, Falush, Daniel, Sheppard, Samuel

Table S1. Isolate details for the global 565 strains dataset. Summary of geographic provenance, fineSTRUCTURE population and source for the global dataset of 565 strains. Table S2. Isolate details for the hpEurope GWAS dataset. Summary of metadata fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4d7e19b3ced8d30e5e8e7e73faee88

Additional file 3: of A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk

Autor: Berthenet, Elvire, Yahara, Koji, Thorell, Kaisa, Pascoe, Ben, Meric, Guillaume, Mikhail, Jane, Engstrand, Lars, Enroth, Helena, Burette, Alain, Megraud, Francis, Varon, Christine, Atherton, John, Sinead Smith, Wilkinson, Thomas, Hitchings, Matthew, Falush, Daniel, Sheppard, Samuel

Figure S3. Representation of the GWAS hits in the 5 non-accessory genes used in calculation of a risk score. All the hits with a p value

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604d478da95bcecb6bc525e46fda09e3

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas

Autor: Thorell, Kaisa, Yahara, Koji, Berthenet, Elvire, Lawson, Daniel J., Mikhail, Jane, Kato, Ikuko, Mendez, Alfonso, Rizzato, Cosmeri, Bravo, María Mercedes, Suzuki, Rumiko, Yamaoka, Yoshio, Torres, Javier, Sheppard, Samuel K., Falush, Daniel

Publikováno v: PLoS Genetics
Thorell, K, Yahara, K, Berthenet, E, Lawson, D J, Mikhail, J, Kato, I, Mendez, A, Rizzato, C, Bravo, M M, Suzuki, R, Yamaoka, Y, Torres, J, Sheppard, S K & Falush, D 2017, ' Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas ', PLoS Genetics, vol. 13, no. 2, e1006546 . https://doi.org/10.1371/journal.pgen.1006546
PLoS Genetics, Vol 13, Iss 2, p e1006546 (2017)

For the last 500 years, the Americas have been a melting pot both for genetically diverse humans and for the pathogenic and commensal organisms associated with them. One such organism is the stomach-dwelling bacterium Helicobacter pylori, which is hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cbbe5e04a9647fe2bf2f0b28edf7037b
http://europepmc.org/articles/PMC5322909