Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mikha, Gabriela"'
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The 6-cysteine protein family is one of the most abundant surface antigens that are expressed throughout the Plasmodium falciparum life cycle. Many members of the 6-cysteine family have critical roles in parasite development across the life cycle in
Externí odkaz:
https://doaj.org/article/f254ed6edaaf46a2a44ad9b15f1fc708
Autor:
Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009977 (2022)
Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those
Externí odkaz:
https://doaj.org/article/255e629500da4e7bab4f1622c9b59485
Autor:
Melanie H. Dietrich, Mikha Gabriela, Kitsanapong Reaksudsan, Matthew W. A. Dixon, Li-Jin Chan, Amy Adair, Stephanie Trickey, Matthew T. O'Neill, Li Lynn Tan, Sash Lopaticki, Julie Healer, Sravya Keremane, Alan F. Cowman, Wai-Hong Tham
Publikováno v:
Biochemical Journal. 479:2529-2546
Transmission blocking interventions can stop malaria parasite transmission from mosquito to human by inhibiting parasite infection in mosquitos. One of the most advanced candidates for a malaria transmission blocking vaccine is Pfs230. Pfs230 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8200538f8b6130bb0907cba51ccb49
https://doi.org/10.1042/bcj20220554
https://doi.org/10.1042/bcj20220554
Autor:
Paul R. Gilson, Mikha Gabriela, Claudia B. G. Barnes, Dickson Leong, Brad E. Sleebs, Molly P. Schneider, Dene R. Littler, Brendan S. Crabb, Tania F. de Koning-Ward
The parasite Plasmodium falciparum causes the most severe form of malaria and to invade and replicate in red blood cells (RBCs), it exports hundreds of proteins across the encasing parasitophorous vacuole membrane (PVM) into this host cell. The expor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0f67dbdc463a1bac5470b0129a82db1
https://doi.org/10.22541/au.167958726.69062799/v1
https://doi.org/10.22541/au.167958726.69062799/v1
Autor:
Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir, David T. Riglar, Oliver Looker, Catherine S. Palmer, Betty Kouskousis, Sarah C. Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo‐Anne Chan, Tania F. de Koning‐Ward, Jake Baum, James W. Kazura, James G. Beeson, Alan F. Cowman, Paul R. Gilson, Brendan S. Crabb
Publikováno v:
Molecular Microbiology. 117:1245-1262
Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite's success is their ability to invade and subsequently grow within human erythrocytes. Parasite proteins involved in para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e333ce452776bb3cf5ddf9a8f4b7c1
https://doi.org/10.1111/mmi.14904
https://doi.org/10.1111/mmi.14904
Autor:
Thorey K. Jonsdottir, Brendan Elsworth, Simon Cobbold, Mikha Gabriela, Sarah C. Charnaud, Madeline G. Dans, Molly Parkyn Schneider, Malcolm McConville, Hayley E. Bullen, Brendan S. Crabb, Paul R. Gilson
A key element ofPlasmodiumbiology and pathogenesis is the trafficking of ~10% of the parasite proteome into the host red blood cell (RBC) it infects. To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ff022b7b4d76b6f7b08f5acf98b01d
https://doi.org/10.1101/2022.11.15.516562
https://doi.org/10.1101/2022.11.15.516562
Autor:
Madeline G. Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Sujaan Das, Molly Parkyn Schneider, Thorey K. Jonsdottir, Mikha Gabriela, Maria R. Gancheva, Christopher J. Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I. McFadden, Danny W. Wilson, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Brad E. Sleebs, Inari Kursula, Paul R. Gilson
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell invasion, and have g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce01f8df6990aa8f2e44e034dbc1bac0
https://doi.org/10.1101/2022.09.29.510018
https://doi.org/10.1101/2022.09.29.510018
Autor:
Thorey K Jonsdottir, Brendan S. Crabb, Mikha Gabriela, Tania F. de Koning-Ward, Paul R. Gilson
Publikováno v:
Trends in Parasitology. 37:664-675
To survive inside red blood cells (RBCs), malaria parasites export many proteins to alter their host cell's physiological properties. Although most proteins of this exportome are involved in immune avoidance or in the trafficking of exported proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70acf5bb4dd67c0bb9618656c5439fe
https://doi.org/10.1016/j.pt.2021.04.009
https://doi.org/10.1016/j.pt.2021.04.009
Autor:
Betty Kouskousis, Paul R. Gilson, Brad E. Sleebs, Thorey Jonsdottir, Tania F. de Koning-Ward, Mikha Gabriela, Hayley E Bullen, Kathryn Matthews, Brendan S. Crabb, Cas Boshoven, David Steer
Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell’s physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of thos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d30330cda0fbc7793fa817761d18014
https://doi.org/10.1101/2021.09.29.462329
https://doi.org/10.1101/2021.09.29.462329