Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Mikel M. Arbulo-Echevarria"'
1
Akademický článek
Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation
Autor: Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Fanghui Zhang, Luis M. Fernandez-Aguilar, Martyna Chotomska, Isaac Narbona-Sánchez, Lichen Zhang, Bernard Malissen, Yinming Liang, Enrique Aguado
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
The LAT transmembrane adaptor is essential to transduce intracellular signals triggered by the TCR. Phosphorylation of its four C-terminal tyrosine residues (136, 175, 195, and 235 in mouse LAT) recruits several proteins resulting in the assembly of
Externí odkaz: https://doaj.org/article/83670c39e1304dc497eced2cd74e5e7d
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2
Akademický článek
A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation
Autor: Luis M. Fernández-Aguilar, Inmaculada Vico-Barranco, Mikel M. Arbulo-Echevarria, Enrique Aguado
Publikováno v: Biology, Vol 12, Iss 9, p 1163 (2023)
Specific antigen recognition is one of the immune system’s features that allows it to mount intense yet controlled responses to an infinity of potential threats. T cells play a relevant role in the host defense and the clearance of pathogens by mea
Externí odkaz: https://doaj.org/article/d28e5af720e34985b10496ab98f32d18
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3
Akademický článek
Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy
Autor: Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Isaac Narbona-Sánchez, Francisco García-Cózar, Arkadiusz Miazek, Enrique Aguado
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential
Externí odkaz: https://doaj.org/article/933a3127c8b144a3aa1f0746ecfad26a
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4
Akademický článek
A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling
Autor: Inmaculada Vico-Barranco, Mikel M. Arbulo-Echevarria, Isabel Serrano-García, Alba Pérez-Linaza, José M. Miranda-Sayago, Arkadiusz Miazek, Isaac Narbona-Sánchez, Enrique Aguado
Publikováno v: Cells, Vol 10, Iss 2, p 343 (2021)
Intracellular signaling through the T cell receptor (TCR) is essential for T cell development and function. Proper TCR signaling requires the sequential activities of Lck and ZAP-70 kinases, which result in the phosphorylation of tyrosine residues lo
Externí odkaz: https://doaj.org/article/5168a13a986c4f56a2f087be6ac54ae6
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5
Akademický článek
A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling
Autor: Mikel M. Arbulo-Echevarria, Isaac Narbona-Sánchez, Cecilia M. Fernandez-Ponce, Inmaculada Vico-Barranco, Mª Dolores Rueda-Ygueravide, Michael L. Dustin, Arkadiusz Miazek, Mª Carmen Duran-Ruiz, Francisco García-Cózar, Enrique Aguado
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
The adaptor protein linker for activation of T cells (LAT) has an essential role transducing activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have shown that upon T-cell activation, LAT interacts with the tyrosine ki
Externí odkaz: https://doaj.org/article/36a9285d1dc445a9a6abb348a64bbff6
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6
Akademický článek
Ultrastructural Localization and Molecular Associations of HCV Capsid Protein in Jurkat T Cells
Autor: Cecilia Fernández-Ponce, Maria C. Durán-Ruiz, Isaac Narbona-Sánchez, Juan P. Muñoz-Miranda, Mikel M. Arbulo-Echevarria, Antonio Serna-Sanz, Christian Baumann, Rocío Litrán, Enrique Aguado, Wilhelm Bloch, Francisco García-Cozar
Publikováno v: Frontiers in Microbiology, Vol 8 (2018)
Hepatitis C virus core protein is a highly basic viral protein that multimerizes with itself to form the viral capsid. When expressed in CD4+ T lymphocytes, it can induce modifications in several essential cellular and biological networks. To shed li
Externí odkaz: https://doaj.org/article/0b39c39b9fc24acebca66178002328b5
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7
Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis
Autor: Isaac Narbona-Sánchez, Alba Pérez-Linaza, Isabel Serrano-García, Inmaculada Vico-Barranco, Luis M. Fernández-Aguilar, José L. Poveda-Díaz, María J. Sánchez del Pino, Fermín Medina-Varo, Mikel M. Arbulo-Echevarria, Enrique Aguado
Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4574
T lymphocytes are key players in adaptive immune responses through the recognition of peptide antigens through the T Cell Receptor (TCR). After TCR engagement, a signaling cascade is activated, leading to T cell activation, proliferation, and differe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0929312dc771181f1c1c6c7b5db1ca1
https://doi.org/10.3390/ijms24054574
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8
A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling
Autor: Arkadiusz Miazek, Enrique Aguado, Inmaculada Vico-Barranco, Alba Pérez-Linaza, Isaac Narbona-Sánchez, Mikel M Arbulo-Echevarria, Jose Maria Miranda-Sayago, Isabel Serrano-García
Publikováno v: Cells, Vol 10, Iss 343, p 343 (2021)
Cells 2021, 10(2), 343
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
Cells
Volume 10
Issue 2
RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
Universidad de Cádiz
Intracellular signaling through the T cell receptor (TCR) is essential for T cell development and function. Proper TCR signaling requires the sequential activities of Lck and ZAP-70 kinases, which result in the phosphorylation of tyrosine residues lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de2151aa531232696f28dcac3111017
https://www.mdpi.com/2073-4409/10/2/343
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9
Slow phosphor-Y-LAT-ion for TCR ligand discrimination
Autor: Enrique Aguado, Mikel M Arbulo-Echevarria
Publikováno v: Nature Immunology. 20:1420-1422
A report sheds new light on the molecular mechanisms responsible for the discrimination of self versus non-self TCR ligands and reveals the crucial role of the kinetics of LAT tyrosine phosphorylation in this.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::029abbc7073f002f8ab2466d1ae6dbbd
https://doi.org/10.1038/s41590-019-0522-y
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10
Immune modulation by the hepatitis C virus core protein
Autor: Enrique Aguado, Mikel M Arbulo-Echevarria, R. Litrán, Juan Pedro Muñoz-Miranda, Francisco García-Cózar, Cecilia Fernández-Ponce, Margarita Dominguez-Villar
Publikováno v: Journal of Viral Hepatitis. 24:350-356
Hepatitis C virus (HCV) infection is currently the most important cause of chronic viral hepatitis in the world and one of the most frequent indications for liver transplantation. HCV uses different strategies to evade the innate and adaptive immune
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bb4e1d645bc20f267fe0b143e9adb8
https://doi.org/10.1111/jvh.12675
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