Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Mikel Hernaez"'
Autor:
Guillermo Serrano, Nerea Berastegui, Aintzane Díaz-Mazkiaran, Paula García-Olloqui, Carmen Rodriguez-Res, Sofia Huerga-Dominguez, Marina Ainciburu, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Asier Ullate-Agote, Beñat Ariceta, Jose-Maria Lamo-Espinosa, Pamela Acha, Oriol Calvete, Tamara Jimenez, Antonieta Molero, Maria Julia Montoro, Maria Díez-Campelo, David Valcarcel, Francisco Solé, Ana Alfonso-Pierola, Idoia Ochoa, Felipe Prósper, Teresa Ezponda, Mikel Hernaez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains unknown. Using single cell RNA-seq (scRNA-seq) on CD34+ progenitors from del(5q) MD
Externí odkaz:
https://doaj.org/article/91536052d5734ebda987ce77dddb892b
Autor:
Fabian Müntefering, Yeremia Gunawan Adhisantoso, Shubham Chandak, Jörn Ostermann, Mikel Hernaez, Jan Voges
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract For the last two decades, the amount of genomic data produced by scientific and medical applications has been growing at a rapid pace. To enable software solutions that analyze, process, and transmit these data in an efficient and interopera
Externí odkaz:
https://doaj.org/article/0a852e8ff85b4568b37ab9e6cbb17094
Autor:
Sergio Barace, Eva Santamaría, Stefany Infante, Sara Arcelus, Jesus De La Fuente, Enrique Goñi, Ibon Tamayo, Idoia Ochoa, Miguel Sogbe, Bruno Sangro, Mikel Hernaez, Matias A. Avila, Josepmaria Argemi
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 653 (2024)
Whole-tissue transcriptomic analyses have been helpful to characterize molecular subtypes of hepatocellular carcinoma (HCC). Metabolic subtypes of human HCC have been defined, yet whether these different metabolic classes are clinically relevant or d
Externí odkaz:
https://doaj.org/article/849503fa0ca248918b9f5150dce46864
Autor:
Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Adriana Tavira, Esther Luquin, Amaya Vilas, Ibon Tamayo, Mikel Hernaez, Pedro Clavero, Elisa Mengual, Sandra Hervás-Stubbs, Maria S. Aymerich
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S268- (2023)
Externí odkaz:
https://doaj.org/article/194545004e734346ab99981d4c930c16
Autor:
Cristina Calviño, Candela Ceballos, Ana Alfonso, Patricia Jauregui, Maria E. Calleja-Cervantes, Patxi San Martin-Uriz, Paula Rodriguez-Marquez, Angel Martin-Mallo, Elena Iglesias, Gloria Abizanda, Saray Rodriguez-Diaz, Rebeca Martinez-Turrillas, Jorge Illarramendi, Maria C. Viguria, Margarita Redondo, Jose Rifon, Sara Villar, Juan J. Lasarte, Susana Inoges, Ascension Lopez-Diaz de Cerio, Mikel Hernaez, Felipe Prosper, Juan R. Rodriguez-Madoz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite the potential of CAR-T therapies for hematological malignancies, their efficacy in patients with relapse and refractory Acute Myeloid Leukemia has been limited. The aim of our study has been to develop and manufacture a CAR-T cell product tha
Externí odkaz:
https://doaj.org/article/f8de5ca01ff34ed9b089165eb0725060
Autor:
Nerea Berastegui, Marina Ainciburu, Juan P. Romero, Paula Garcia-Olloqui, Ana Alfonso-Pierola, Céline Philippe, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Raquel Ruiz-Hernández, Ander Abarrategi, Raquel Ordoñez, Diego Alignani, Sarai Sarvide, Laura Castro-Labrador, José M. Lamo-Espinosa, Mikel San-Julian, Tamara Jimenez, Félix López-Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Maria Julia Montoro, Bárbara Tazón, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Mikel Hernaez, Sofía Huerga, Findlay Bewicke-Copley, Ana Rio-Machin, Matthew T. Maurano, María Díez-Campelo, David Valcarcel, Kevin Rouault-Pierre, David Lara-Astiaso, Teresa Ezponda, Felipe Prosper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Myelodysplastic syndromes (MDS) are age-related pathologies in which alterations of hematopoietic stem cells lead to abnormal formation of blood cells. Here, the authors study the lesions that these cells undergo in aging and disease, characterizing
Externí odkaz:
https://doaj.org/article/5a52f5ed769d4553afa3673e2f1e7052
Autor:
Jianhao Peng, Guillermo Serrano, Ian M. Traniello, Maria E. Calleja-Cervantes, Ullas V. Chembazhi, Sushant Bangru, Teresa Ezponda, Juan Roberto Rodriguez-Madoz, Auinash Kalsotra, Felipe Prosper, Idoia Ochoa, Mikel Hernaez
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
SimiC, a single-cell gene regulatory inference framework is presented that can infer multiple gene regulatory networks across related cell phenotypes, unraveling complex regulatory dynamics.
Externí odkaz:
https://doaj.org/article/fa439cbcedcc415a9f8c9bea20c8ce19
Autor:
Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso-Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Diego Alignani, Jose Lamo-Espinosa, Mikel San-Julian, Tamara Jiménez-Solas, Felix Lopez, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Julia Montoro, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Miren Lasaga, David Gomez-Cabrero, Maria Diez-Campelo, David Valcarcel, Mikel Hernaez, Juan P Romero, Felipe Prosper
Publikováno v:
eLife, Vol 12 (2023)
Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regu
Externí odkaz:
https://doaj.org/article/3e9c063b4a474f658aaf2538b69955f6
Autor:
Katherine I. Kendig, Saurabh Baheti, Matthew A. Bockol, Travis M. Drucker, Steven N. Hart, Jacob R. Heldenbrand, Mikel Hernaez, Matthew E. Hudson, Michael T. Kalmbach, Eric W. Klee, Nathan R. Mattson, Christian A. Ross, Morgan Taschuk, Eric D. Wieben, Mathieu Wiepert, Derek E. Wildman, Liudmila S. Mainzer
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
As reliable, efficient genome sequencing becomes ubiquitous, the need for similarly reliable and efficient variant calling becomes increasingly important. The Genome Analysis Toolkit (GATK), maintained by the Broad Institute, is currently the widely
Externí odkaz:
https://doaj.org/article/b076819b29154520ae8fcd0ae92e64c5
Autor:
Charles Blatti, Jesús de la Fuente, Huanyao Gao, Irene Marín-Goñi, Zikun Chen, Sihai D. Zhao, Winston Tan, Richard Weinshilboum, Krishna R. Kalari, Liewei Wang, Mikel Hernaez
Publikováno v:
Cancer Research. 83:1361-1380
Survival rates of patients with metastatic castration-resistant prostate cancer (mCRPC) are low due to lack of response or acquired resistance to available therapies, such as abiraterone (Abi). A better understanding of the underlying molecular mecha