Structure-based classification of tauopathies

Autor: Fuyuki Kametani, Ruben Vidal, Mike van Beers, Abhay Kotecha, H. Tanaka, Airi Tarutani, Tammaryn Lashley, Wenjuan Zhang, Yang Yang, Yang Shi, Benjamin Falcon, Takeshi Ikeuchi, Michel Goedert, Sjors H.W. Scheres, Holly J. Garringer, Bernardino Ghetti, Gabor G. Kovacs, Mari Yoshida, Masato Hasegawa, Akiyoshi Kakita, Alexey G. Murzin, Andrew C Robinson, David M. A. Mann, Tamas Revesz, Yuko Saito, G.I. Hallinan, Shigeo Murayama

Publikováno v: Nature
Shi, Y, Zhang, W, Yang, Y, Murzin, A G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H J, Vidal, R, Hallinan, G I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A C, Mann, D M A, Kovacs, G G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M & Scheres, S H W 2021, ' Structure-based classification of tauopathies ', Nature, vol. 598, no. 7880, pp. 359-363 . https://doi.org/10.1038/s41586-021-03911-7

Ordered assembly of the tau protein into filaments characterizes multiple neurodegenerative diseases, which are called tauopathies. We previously reported that by electron cryo-microscopy (cryo-EM), tau filament structures from Alzheimer’s disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df46db44639458e3f071db56fadf1871
https://doi.org/10.1038/s41586-021-03911-7