Whole-body galactose oxidation as a robust functional assay to assess the efficacy of gene-based therapies in a mouse model of Galactosemia

Autor: Bijina Balakrishnan, Xinhua Yan, Marshall D. McCue, Olivia Bellagamba, Aaron Guo, Felicity Winkler, Jason Thall, Lisa Crawford, Rain Dimen, Sara Chen, Sean McEnaney, Yiman Wu, Mike Zimmer, Joe Sarkis, Paolo G.V. Martini, Patrick F. Finn, Kent Lai

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101191- (2024)

Despite the implementation of lifesaving newborn screening programs and a galactose-restricted diet, many patients with classic galactosemia develop long-term debilitating neurological deficits and primary ovarian insufficiency. Previously, we showed

Externí odkaz: https://doaj.org/article/d2fda7725fe9434a86e2d785a3e6d368

mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease

Autor: Christopher Tunkey, Minjung Choi, Wei Zheng, Gilles Besin, Lisa M. Rice, Andrea Frassetto, Athanasios Dousis, Edward J. Miracco, Uma Rajarajacholan, Erik Owen, Patrick Finn, Fabienne Rajas, Eleonora Guadagnin, Kristin E. Burke, Mike Zimmer, Vincent Verzieux, Christopher Pepin, Cosmin Mihai, meredith##Wolfrom, Maud Soty, Becca Levy, Joe Sarkis, Zach Zalinger, Barbara Tran, Marine Silva, Arianna Markel, Ling Yin, Paloma H. Giangrande, Vi Nguyen, Jingsong Cao, Marjie Hard, Paolo Martini, Gilles Mithieux, Jenny Zhuo, Shi Liang, Edward Weisser, Vladimir Presnyak, Anne-Renee##Graham, Tatiana Ketova, Lei Ci

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3090. ⟨10.1038/s41467-021-23318-2⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Glycogen Storage Disease 1a (GSD1a) is a rare, inherited metabolic disorder caused by deficiency of glucose 6-phosphatase (G6Pase-α). G6Pase-α is critical for maintaining interprandial euglycemia. GSD1a patients exhibit life-threatening hypoglycemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdb1236707c2ddf86e727dfcbc9b5e5
http://europepmc.org/articles/PMC8149455

La nature courroucée : quelques enjeux cinématographiques

Autor: Mike Zimmerman

Publikováno v: Voix Contemporaines, Iss 04 (2023)

Ce travail propose de montrer que le cinéma de science-fiction est une catégorie esthétique qui cherche à inventer de nouvelles représentations de la nature courroucée. Il sera question de saisir le rapport complexe du cinéma avec la philosoph

Externí odkaz: https://doaj.org/article/5bafd5ab2b304fb693870241ed69eae7

Myoglobin-like aerotaxis transducers in Archaea and Bacteria

Autor: George W. Ordal, Mike Zimmer, Ece Karatan, Dmitri Y. Boudko, Randy W. Larsen, Shaobin Hou, Charles W. Riley, Maqsudul Alam

Publikováno v: Nature. 403:540-544

Haem-containing proteins such as haemoglobin and myoglobin play an essential role in oxygen transport and storage. Comparison of the amino-acid sequences of globins from Bacteria and Eukarya suggests that they share an early common ancestor, even tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad1f3ec850313f0b9ce5fdc96bd3028
https://doi.org/10.1038/35000570

The Last Gene of the fla/che Operon in Bacillus subtilis, ylxL, Is Required for Maximal σD Function

Autor: Leticia Márquez-Magaña, P. Lopez, M. Mendel, Mike Zimmer, George W. Ordal, H. Werhane

ylxL was found to be the last gene of the fla/che operon in Bacillus subtilis and is cotranscribed with the gene for the flagellum-specific alternate sigma factor, σ D . The ylxL gene was disrupted by insertional mutagenesis, and the resultant mutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5274f358a215b9fe1e2c2c1e5de8c0dc
https://europepmc.org/articles/PMC419943/