Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mike Y Zhong"'
Autor:
Michele Moschetta, Paul G. Richardson, Xiaoyan Feng, Michele Cea, Mike Y Zhong, Antonia Cagnetta, Lugui Qiu, Yu-Tzu Tai, Nikhil C. Munshi, Kenneth Wen, Kenneth C. Anderson, Hans van Eenennaam, Andrea van Elsas, Gang An, Chirag Acharya
Publikováno v:
Blood. 127(25)
Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) progression in vivo. BCMA downregulation strongly decreases viability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664ffb3543b175f21a4126aa17e9d22c
https://pubmed.ncbi.nlm.nih.gov/27127303
https://pubmed.ncbi.nlm.nih.gov/27127303
Autor:
Mike Y Zhong, Fenghuang Zhan, William Senapedis, S. A. Schey, Andrew L. Kung, Paul G. Richardson, Yolanda Calle, Chirag Acharya, Michaela R. Reagan, Nikhil C. Munshi, Irene M. Ghobrial, Trinayan Kashyap, Michele Cea, Sharon Shacham, Kenneth C. Anderson, M. Kauffman, Daniel Tannenbaum, Lizi Wu, Jean-Richard Saint-Martin, Antonia Cagnetta, Aditya Munshi, Yumei Gu, Yosef Landesman, Yu-Tzu Tai
The key nuclear export protein CRM1/XPO1 may represent a promising novel therapeutic target in human multiple myeloma (MM). Here we showed that chromosome region maintenance 1 (CRM1) is highly expressed in patients with MM, plasma cell leukemia cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0cfd0f2cee582e49074d8075af2064
http://hdl.handle.net/11567/822469
http://hdl.handle.net/11567/822469
Autor:
Mike Y Zhong, John Yates, Amanda L. Christie, Bao Hoang, Yu-Tzu Tai, Michele Cea, Patrick A. Mayes, Louise Gliddon, Jenny L Craigen, Kenneth C. Anderson, Paul G. Richardson, William E. Fieles, Nikhil C. Munshi, Andrew L. Kung, James Tunstead, Antonia Cagnetta, Chirag Acharya
B-cell maturation antigen (BCMA), highly expressed on malignant plasma cells in human multiple myeloma (MM), has not been effectively targeted with therapeutic monoclonal antibodies. We here show that BCMA is universally expressed on the MM cell surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b888169738a4539e0bee656bbf32c0d9
http://hdl.handle.net/11567/826118
http://hdl.handle.net/11567/826118
Autor:
Kenneth C. Anderson, Yu-Tzu Tai, Antonia Cagnetta, Chirag Acharya, Paul G. Richardson, Michele Cea, Nikhil C. Munshi, Dharminder Chauhan, Teru Hideshima, Mike Y Zhong, Teresa Calimeri, Mariateresa Fulciniti, Alessio Nencioni, Marco Gobbi, Franco Patrone
We recently demonstrated that Nicotinamide phosphoribosyltransferase (Nampt) inhibition depletes intracellular NAD⁺ content leading, to autophagic multiple myeloma (MM) cell death. Bortezomib has remarkably improved MM patient outcome, but dose-lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc629c4b7dc7f4e655f29f9401fa932
http://hdl.handle.net/11567/631805
http://hdl.handle.net/11567/631805
Autor:
Gang An, Mike Y Zhong, Hans van Eenennaam, Kenneth Wen, Chirag Acharya, Michele Moschetta, Andrea van Elsas, Kenneth C. Anderson, Michele Cea, Yu-Tzu Tai, Xiaoyan Feng, Nikhil C. Munshi, Antonia Cagnetta
Publikováno v:
Cancer Research. 76:3283-3283
Elevated B cell maturation antigen (BCMA) and its ligand a proliferation-inducing ligand (APRIL) may directly advance human multiple myeloma (MM) malignancy in vivo. Here, we first show that BCMA downregulation potently diminishes viability and colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e34e4737cdabf5c4737e0f0736affbc
https://doi.org/10.1158/1538-7445.am2016-3283
https://doi.org/10.1158/1538-7445.am2016-3283
Autor:
Chirag Acharya, Yu-Tzu Tai, Sun-Young Kong, Antonia Cagnetta, Yiguo Hu, Jianjun Zhao, Betty Y. Chang, Laurence Elias, Michele Cea, Mike Y Zhong, Michael A. Sellitto, Yolanda Calle, Jianhong Lin, Kenneth C. Anderson, Mariateresa Fulciniti, Daniel R. Carrasco, Steven P. Treon, Paul G. Richardson, Nikhil C. Munshi, Joseph J. Buggy, Qiuju Wang, William Matsui, Guang Yang
Bruton tyrosine kinase (Btk) has a well-defined role in B-cell development, whereas its expression in osteoclasts (OCs) further suggests a role in osteoclastogenesis. Here we investigated effects of PCI-32765, an oral and selective Btk inhibitor, on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f9a3c476b9761f5a71f9b5a7ddd62f
http://hdl.handle.net/11567/822470
http://hdl.handle.net/11567/822470
Autor:
Yu-Tzu Tai, Kenneth C. Anderson, Gang An, Andrea van Elsas, Mike Y Zhong, Hua Jiang, Xiaoyan Feng, Hans van Eenennaam, Chirag Acharya, Nikhil C. Munshi
Publikováno v:
Cancer Research. 75:394-394
A proliferation-inducing ligand (APRIL), a close member of B-cell-activating factor (BAFF) belonging to the TNF superfamily, is mainly produced by bone marrow (BM) accessory cells to stimulates growth and survival of multiple myeloma (MM) cells. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6795a3f86683dfbc32dc3d6f7b1aba4a
https://doi.org/10.1158/1538-7445.am2015-394
https://doi.org/10.1158/1538-7445.am2015-394
Autor:
Chirag Acharya, Hua Jiang, Kenneth C. Anderson, Gang An, Michele Cea, Yu-Tzu Tai, Mike Y Zhong, Antonia Cagnetta
Publikováno v:
Blood. 124:3384-3384
B cell maturation antigen (BCMA), selectively elevated in malignant plasma cells, is an ideal target antigen for immunotherapies for multiple myeloma (MM). Most recently, we reported novel antagonistic anti-BCMA antibody drug conjugates (ADCs) showin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5adb3fb796848de3d579d79ea7622c
https://doi.org/10.1182/blood.v124.21.3384.3384
https://doi.org/10.1182/blood.v124.21.3384.3384
Autor:
Mike Y Zhong, Andrea van Elsas, Michele Cea, Hua Jiang, Kenneth C. Anderson, Hans van Eenennaam, Gang An, Nikhil C. Munshi, Antonia Cagnetta, Chirag Acharya, Yu-Tzu Tai
Publikováno v:
Blood. 124:2098-2098
A proliferation-inducing ligand (APRIL), a close member of B-cell-activating factor (BAFF) belonging to the TNF superfamily, is mainly produced by bone marrow (BM) accessory cells to stimulates growth and survival of multiple myeloma (MM) cells. Unli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b26bd36fbc75d14035a5024ba4248247
https://doi.org/10.1182/blood.v124.21.2098.2098
https://doi.org/10.1182/blood.v124.21.2098.2098
Autor:
Yu-Tzu Tai, Mike Y Zhong, Kenneth C. Anderson, Francisco Adrian, Ti Cai, Nikhil C. Munshi, Guang Yang, Zhili Song, Gang An, Chirag Acharya, Hua Jiang
Publikováno v:
Blood. 124:2124-2124
SAR650984 (SAR) is a naked humanized IgG1 monoclonal antibody (mAb) selectively targeting the membrane protein CD38 in early clinical development to treat multiple myeloma (MM) and other CD38+ hematological malignancies. SAR has demonstrated encourag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460d0d698e154d50365e3eebc4ebf6da
https://doi.org/10.1182/blood.v124.21.2124.2124
https://doi.org/10.1182/blood.v124.21.2124.2124