Pharmacokinetics of carfilzomib in patients with advanced malignancies and varying degrees of hepatic impairment: an open-label, single-arm, phase 1 study

Autor: Jennifer Brown, Ruth Plummer, Todd M. Bauer, Stephen Anthony, John Sarantopoulos, Filip De Vos, Mike White, Marco Schupp, Ying Ou, Ulka Vaishampayan

Publikováno v: Experimental Hematology & Oncology, Vol 6, Iss 1, Pp 1-12 (2017)

Abstract Background Carfilzomib is approved in the United States and Europe for treatment of relapsed or refractory multiple myeloma (MM). This study evaluated pharmacokinetics (PK) and safety of carfilzomib in patients with relapsed or progressive a

Externí odkaz: https://doaj.org/article/5ba1529aaac44354a5cefdad2b8a0f35

Cell cycle phase regulates glucocorticoid receptor function.

Autor: Laura Matthews, James Johnson, Andrew Berry, Peter Trebble, Ann Cookson, Dave Spiller, Caroline Rivers, Michael Norman, Mike White, David Ray

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22289 (2011)

The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors. In contrast to many other nuclear receptors, GR is thought to be exclusively cytoplasmic in quiescent cells, and only

Externí odkaz: https://doaj.org/article/a34ed37689b244439d13b2228f8e1918

Miscarriages of justice in New Zealand

Autor: Mike White

Publikováno v: Murder, Wrongful Conviction and the Law ISBN: 9781003251484

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bda07f3b778930f69d63cf6b2f2fa8c2
https://doi.org/10.4324/9781003251484-13

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

Autor: Mingyu He, Kate Roussak, Feiyang Ma, Nicholas Borcherding, Vince Garin, Mike White, Charles Schutt, Trine I. Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Ulezko Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew M. Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert L. Modlin, Ryan C. Fields, Robert D. Schreiber, Paul M. Allen, Eynav Klechevsky

Publikováno v: He, M, Roussak, K, Ma, F, Borcherding, N, Garin, V, White, M, Schutt, C, Jensen, T I, Zhao, Y, Iberg, C A, Shah, K, Bhatia, H, Korenfeld, D, Dinkel, S, Gray, J, Ulezko Antonova, A, Ferris, S, Donermeyer, D, Lindestam Arlehamn, C, Gubin, M M, Luo, J, Gorvel, L, Pellegrini, M, Sette, A, Tung, T, Bak, R, Modlin, R L, Fields, R C, Schreiber, R D, Allen, P M & Klechevsky, E 2023, ' CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses ', Science, vol. 379, no. 6633, eabg2752 . https://doi.org/10.1126/science.abg2752

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph node

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb58f3075eb648887329399a6257400
https://pure.au.dk/portal/da/publications/cd5-expression-by-dendritic-cells-directs-t-cell-immunity-and-sustains-immunotherapy-responses(0a5862aa-3391-473b-9491-d06b9b57ccb2).html

Abstract 6093: IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets homologous-recombination-deficient and PARP inhibitor resistant breast and ovarian tumors

Autor: Monah Abed, Diana Muñoz, Vidya Seshadri, Steve Federowicz, Arjun A. Rao, Deepthi Bhupathi, Marya Liimatta, Rita Ousterhout, Firoz Jaipuri, Claire Neilan, Mark Lackner, Mike White, Zineb Mounir

Publikováno v: Cancer Research. 83:6093-6093

Poly (ADP-ribose) polymerase inhibitors (PARPi) were the first clinically approved drugs designed to exploit synthetic lethality. Despite initial responses, patients harboring homologous recombination (HR) alterations that receive PARPi develop treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::360035d9122cbe3c5020c7fd57598c2f
https://doi.org/10.1158/1538-7445.am2023-6093