Výsledky vyhledávání - "Mike W. Denhoff"

Akademický článek

From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology

Autor: Christophe ePy, Marzia eMartina, Gerardo A Diaz-Quijada, Collin C Luk, Dolores eMartinez, Mike W Denhoff, Anne eCharrier, Tanya eComas, Robert eMonette, Anthony eKrantis, Naweed I Syed, Geoffrey A.R. Mealing

Publikováno v: Frontiers in Pharmacology, Vol 2 (2011)

All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders. Consequently, to

Externí odkaz: https://doaj.org/article/5c8dd0c78f85462c8f0d89c0fc2ef82a

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Minority carrier diffusion lengths and mobilities in low-doped n-InGaAs for focal plane array applications

Autor: Mike W. Denhoff, Alexandre W. Walker

The hole diffusion length in n-InGaAs is extracted for two samples of different doping concentrations using a set of long and thin diffused junction diodes separated by various distances on the order of the diffusion length. The methodology is descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7693e21033a43cf66dde58f6f039091d
http://arxiv.org/abs/1707.08023

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Heavy and light hole minority carrier transport properties in low-doped n-InGaAs lattice matched to InP

Autor: Alexandre W. Walker, Mike W. Denhoff

Minority carrier diffusion lengths in low-doped n-InGaAs using InP/InGaAs double-heterostructures are reported using a simple electrical technique. The contributions from heavy and light holes are also extracted using this methodology, including mino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cd15ac754fa3e2a67147d77f0e8a37

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Polymer peel-off mask for high-resolution surface derivatization, neuron placement and guidance

Autor: Mike W. Denhoff, Anthony Krantis, Christophe Py, Geoffrey A.R. Mealing, Tanya Comas, Robert Monette, Dolores Martinez

We present a dry lift-off method using a chemically resistant spin-on plastic, polyimide, to pattern surfaces with high accuracy and resolution. Using well-known lithographic and reactive ion etching techniques, the spin-on polymer is patterned over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67559b00aa190fbd3c305cf883b5018
https://doi.org/10.1002/bit.24887

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Development of patch-clamp chips for mammalian cell applications

Autor: Tanya Comas, Laura Kremer, Marzia Martina, Christophe Py, Geoff Mealing, Danish Salim, Mike W. Denhoff, Dolores Martinez, Robert Monette

We have previously described the designs of two planar patch-clamp neurochips and their application to the electrophysiological study of molluscan neurons cultured on-chip. Neuron attachment and growth over apertures on the neurochip surface permitte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b06f672bc0a3ecab3ef8a0985fa4b76
https://nrc-publications.canada.ca/eng/view/object/?id=fed3f356-458d-4def-88b1-0531e5c6d26b

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A novel silicon patch-clamp chip permits high-fidelity recording of ion channel activity from functionally defined neurons

Autor: Tarun Ahuja, Simon Wingar, Robert Monette, Alexei Bogdanov, Marzia Martina, Christophe Py, John G. Mielke, Naweed I. Syed, Juan Caballero, Tanya Comas, Collin C. Luk, Mike W. Denhoff, Dolores Martinez, S. R. Laframboise, Geoff Mealing

We report on a simple and high-yield manufacturing process for silicon planar patch-clamp chips, which allow low capacitance and series resistance from individually identified cultured neurons. Apertures are etched in a high-quality silicon nitride f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c7dfb82993de2e0fc69268b0dc1f72
https://doi.org/10.1002/bit.22834

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High-fidelity patch-clamp recordings from neurons cultured on a polymer microchip

Autor: Marzia Martina, Christophe Py, Geoff Mealing, Naweed I. Syed, Tanya Comas, Robert Monette, Mike W. Denhoff, Collin C. Luk, Dolores Martinez

We present a polymer microchip capable of moni- toring neuronal activity with a fidelity never before obtained on a planar patch-clamp device. Cardio-respiratory neurons Left Pedal Dorsal 1 (LPeD1) from mollusc Lymnaea were cultured on the microchip�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58af362b9fe15f9d18e5c52b81a5f7f
https://doi.org/10.1007/s10544-010-9452-z

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Culturing and electrophysiology of cells on NRCC patch-clamp chips

Autor: Naweed I. Syed, Collin C. Luk, Marzia Martina, Christophe Py, Robert Monette, Tanya Comas, Mike W. Denhoff, Geoff Mealing

Publikováno v: Journal of Visualized Experiments : JoVE

Due to its exquisite sensitivity and the ability to monitor and control individual cells at the level of ion channels, patch-clamping is the gold standard of electrophysiology applied to disease models and pharmaceutical screens alike 1. The method t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fce2e779010a8ed943d736d0c5f9fe
https://nrc-publications.canada.ca/eng/view/object/?id=79045277-4ce7-41ef-870f-fc931d26a1a9

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From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology

Autor: Mike W. Denhoff, Tanya Comas, Collin C. Luk, Geoffrey A.R. Mealing, Robert Monette, Anthony Krantis, Gerardo A. Diaz-Quijada, Dolores Martinez, Naweed I. Syed, Anne Charrier, Marzia Martina, Christophe Py

Publikováno v: Frontiers in Pharmacology, Vol 2 (2011)
Frontiers in Pharmacology
Frontiers in Pharmacology, Frontiers, 2011, 2, pp.51. ⟨10.3389/fphar.2011.00051⟩
Frontiers in Pharmacology, 2011, 2, pp.51. ⟨10.3389/fphar.2011.00051⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6df24a4535a10fa792f4ee3b2f6872b
http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00051/full

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