Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mike W Helms"'
Autor:
Lars M. König, Bodo Brunner, Simon Rothenfußer, Sabine Scheidler, Dmitri Wiederschain, Stefan Endres, Max M. Schnurr, Timothy R. Wagenaar, Hui Cao, Joachim Theilhaber, Kaj Grandien, Petra Scherer, Gabriele Dietert, Monika Braun, Christiane Metz-Weidmann, Felix Gnerlich, Kerstin Jahn-Hofmann, Mike W. Helms
Supplementary Figure S1 shows that RIG-I, MDA and IRF7 mRNA expression are correlated to the Type I IFN signature in melanoma, while MAVS, TBK1 and IRF3 are not. Supplementary Figure S2 shows a list of gene products correlated with RIG-I expression b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a4da953aaf859e66a4a0df15ab8f8b
https://doi.org/10.1158/1535-7163.22505878.v1
https://doi.org/10.1158/1535-7163.22505878.v1
Autor:
Burkhard H. Brandt, Horst Buerger, Sheng-Yung Chang, Alice Wang, Kai Bartkowiak, Heike Pospisil, Christopher H. Contag, Dirk Kemming, Mike W. Helms
Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer. In a cellular model of this phenotype using dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ef5304f76b1dd8d9ed4f893c13f90b
https://doi.org/10.1158/0008-5472.c.6498384
https://doi.org/10.1158/0008-5472.c.6498384
Autor:
Burkhard H. Brandt, Horst Buerger, Sheng-Yung Chang, Alice Wang, Kai Bartkowiak, Heike Pospisil, Christopher H. Contag, Dirk Kemming, Mike W. Helms
Supplementary Tables 1-8 from TOB1 Is Regulated by EGF-Dependent HER2 and EGFR Signaling, Is Highly Phosphorylated, and Indicates Poor Prognosis in Node-Negative Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188e167a42362fba1d97e38070e354d4
https://doi.org/10.1158/0008-5472.22376955
https://doi.org/10.1158/0008-5472.22376955
Autor:
Christiane Metz-Weidmann, Elsa Pflimlin, Kerstin Jahn-Hofmann, Ziyu Li, Bodo Brunner, Sabine Scheidler, Armin Hofmeister, Merle M Weitzenberg, Arne Krack, Mike W Helms, Oliver Plettenburg, Michael Kurz
Publikováno v:
Journal of Medicinal Chemistry. 64:6838-6855
A morpholine-based nucleotide analog was developed as a building block for hepatic siRNA targeting and stabilization. Attachment of an asialoglycoprotein-binding GalNAc ligand at the morpholine nitrogen was realized with different linkers. The obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da575d8ed74811c57899552ba2f2ae2c
https://doi.org/10.1021/acs.jmedchem.1c00144
https://doi.org/10.1021/acs.jmedchem.1c00144
Autor:
Lars M. König, Timothy R. Wagenaar, Simon Rothenfußer, Monika Braun, Hui Cao, Christiane Metz-Weidmann, Gabriele Dietert, Sabine Scheidler, Max Schnurr, Kaj Grandien, Felix Gnerlich, Dmitri Wiederschain, Joachim Theilhaber, Stefan Endres, Kerstin Jahn-Hofmann, Mike W. Helms, Petra Scherer, Bodo Brunner
Publikováno v:
Molecular Cancer Therapeutics. 18:2343-2356
The pattern recognition receptor RIG-I plays an important role in the recognition of nonself RNA and antiviral immunity. RIG-I's natural ligand, triphosphate RNA (ppp-RNA), is proposed to be a valuable addition to the growing arsenal of cancer immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe637e7d26f0964569f49676c0e5b05c
https://doi.org/10.1158/1535-7163.mct-18-1262
https://doi.org/10.1158/1535-7163.mct-18-1262
Autor:
Mike W Helms, Sabine Scheidler, Volker Adam, Carlo Boutton, Bodo Brunner, Peter Casteels, Christiane Metz-Weidmann, Luciana Zimmermann, Pieter Deschaght, Matthias Ozog, Josefine Peterka, Kerstin Jahn-Hofmann, Timothy R. Wagenaar, Oleksandr Zavoiura
Publikováno v:
Molecular pharmaceutics. 18(3)
Targeted extrahepatic delivery of siRNA remains a challenging task in the field of nucleic acid therapeutics. An ideal delivery tool must internalize siRNA exclusively into the cells of interest without affecting the silencing activity of siRNA. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87590d39a9b3f6da8a987a11426029e9
https://pubmed.ncbi.nlm.nih.gov/33444501
https://pubmed.ncbi.nlm.nih.gov/33444501
Autor:
Iina Laitinen, Aimo Kannt, Volker Derdau, Petra Scherer, Jens Atzrodt, Seth Jones, Claudia Loewe, Sheila Cummings, Michael Wagner, Manfred Schudok, Alleyn T Plowright, Herman Schreuder, Erik Bader, Thomas Licher, Tamara R. Castañeda, Gernot Zech, Anurag Mishra, Meltsje de Hoop, Bettina Elshorst, Dinesh S. Bangari, Christoph Pöverlein, Mike W Helms
Publikováno v:
Advanced Science
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early diagnosis of NASH is vital to detect disease before it becomes life‐threatening, yet nonin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e7ee74070bf09cc3a98c8bc45cf527
https://publica.fraunhofer.de/handle/publica/269701
https://publica.fraunhofer.de/handle/publica/269701
Autor:
Chaomei Shi, Mikhail Levit, Tai-Guang Jin, Dinesh S. Bangari, Zhihu Ding, Tatiana Tolstykh, Karl Mamaat, Joern Hopke, Susan Ryan, Lan Jiang, Hui Cao, Qunyan Yu, Dietmar Hoffmann, Hui Qu, Liang Schweizer, Sabine Scheidler, Fangxian Sun, Douglas D. Fang, May Cindhuchao, Christopher Winter, Dmitri Wiederschain, Jack Pollard, Mike W. Helms, Kerstin Jahn-Hofmann
Publikováno v:
Oncotarget
Hepatocellular carcinoma (HCC) represents a serious public health challenge with few therapeutic options available to cancer patients.Wnt/β-catenin pathway is thought to play a significant role in HCC pathogenesis. In this study, we confirmed high f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654fb787b0888a66e884cb56ed5fa868
https://doi.org/10.18632/oncotarget.21298
https://doi.org/10.18632/oncotarget.21298
Autor:
Lars M. König, Stefan Endres, Tim Wagenaar, Dmitri Wiederschain, Eric Parmantier, Sabine Scheidler, Joachim Theilhaber, Gabriele Dietert, Monika Braun, Bodo Brunner, Hui Cao, Max Schnurr, Felix Gnerlich, Kerstin Jahn-Hofmann, Simon Rothenfusser, Kaj Grandien, Christiane Metz-Weidmann, Mike W Helms
Publikováno v:
Cancer Research. 79:5024-5024
RIG-I is a highly important cytosolic pattern recognition receptor (PRR) involved in sensing RNA virus infection and inducing interferon (IFN) production. RIG-I’s natural ligand, triphosphate RNA (ppp-RNA), is proposed to be a valuable addition to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80ddf3fdadd9bafddfe9a2f35e05edb
https://doi.org/10.1158/1538-7445.am2019-5024
https://doi.org/10.1158/1538-7445.am2019-5024
Autor:
Mike W Helms, Walter Stöcker, Gertrud Brachtendorf, Eva Grosse Berkhoff, Frank Wegmann, Oliver Schilling, Irene Yiallouros, Jasna Peter-Katalinić, Astrid Auge, Simone König, Hans Jürgen Hinz, Bernd Beermann, Reinhild Kappelhoff
Astacin (EC 3.4.24.21) is a prototype for the astacin family and for the metzincin superfamily of zinc peptidases, which comprise membrane-bound and secreted enzymes involved in extracellular proteolysis during tissue development and remodelling. Gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd875a3c701d9b7e7d3d8dd2ccc0f11f
https://doi.org/10.1016/s0022-2836(02)01102-6
https://doi.org/10.1016/s0022-2836(02)01102-6