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pro vyhledávání: '"Mike Van Slingerland"'
Autor:
Hildegard Boss, Kirsten M. Bommele, Armin Hatzelmann, Geert Jan Sterk, Margaretha Van Der Mey, Hendrik Timmerman, Mike Van Slingerland
Publikováno v:
Journal of Medicinal Chemistry. 46:2008-2016
In this study, the synthesis and in vitro and in vivo pharmacological investigations of a new series of phthalazinone/pyridazinone hybrids with both PDE3 and PDE4 inhibitory activities are described. These compounds combine the pharmacophores of rece