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pro vyhledávání: '"Mike Sturgess"'
Publikováno v:
Journal of Medicinal Chemistry. 42:4394-4404
The glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, given its potential as pharmacological target, has been thoroughly studied by structure-activity relationships, which has made possible its description in terms of spatial limits a
Publikováno v:
Journal of Receptors and Signal Transduction. 19:547-557
The glycine co-agonist binding site of the NMDA receptor is a target for the prevention and treatment of neurotoxic and neurodegenerative conditions. Until now, the interactions taking place at this site, and its structure, have been investigated by
Publikováno v:
Neuron. 18(3):493-503
NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel activation. The glycine binding site of these heteromeric receptor proteins is formed by regions of the NMDAR1 (NR1) subunit that display sequence similarity to b