Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Mike Strauss"'
Autor:
Michael R. Wozny, Valentin Nelea, Iram Fatima S. Siddiqui, Shaynah Wanga, Vivian de Waard, Mike Strauss, Dieter P. Reinhardt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms. MFAP4 multime
Externí odkaz:
https://doaj.org/article/77dac9f9c47942b7b5f0d8d66ef6937b
Autor:
Camille Marie Fortinez, Kristjan Bloudoff, Connor Harrigan, Itai Sharon, Mike Strauss, T. Martin Schmeing
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nonribosomal peptide synthetases work with additional enzymes to synthesise secondary metabolites and therapeutics. Here, the authors explore bacillamide D synthesis and show the oxidase action is done while the intermediate is attached to the synthe
Externí odkaz:
https://doaj.org/article/6971c7b97c344c57a8f747e25dad5177
Autor:
John D. Bartlett, Charles E. Smith, Yuanyuan Hu, Atsushi Ikeda, Mike Strauss, Tian Liang, Ya-Hsiang Hsu, Amanda H. Trout, David W. McComb, Rebecca C. Freeman, James P. Simmer, Jan C.-C. Hu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Dental enamel forms extracellularly as thin ribbons of amorphous calcium phosphate (ACP) that initiate on dentin mineral in close proximity to the ameloblast distal membrane. Secreted proteins are critical for this process. Enam −/− and
Externí odkaz:
https://doaj.org/article/373d5cee0dcd4f0582e0f4f3a8212285
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The initial transfer of genomic material from a virus into a host cell is a key step in any viral infection. Consequently, understanding how viruses deliver their genomes into cells could reveal attractive therapeutic targets.
Externí odkaz:
https://doaj.org/article/d51b1a60549c4cc3b03c4aacdf68bbc1
Autor:
Ksenia Finogenova, Jacques Bonnet, Simon Poepsel, Ingmar B Schäfer, Katja Finkl, Katharina Schmid, Claudia Litz, Mike Strauss, Christian Benda, Jürg Müller
Publikováno v:
eLife, Vol 9 (2020)
Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3). At transcriptionally active genes, di- and tri-methylated H3K36 inhibit PRC2. Here, the cryo-EM structure of PRC2 on din
Externí odkaz:
https://doaj.org/article/b56404b7d88d4c11888da6a19bb84f37
Autor:
Pranav N M Shah, David J Filman, Krishanthi S Karunatilaka, Emma L Hesketh, Elisabetta Groppelli, Mike Strauss, James M Hogle
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008920 (2020)
The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at the two and quasi-three-fold symmetry axes of the capsid. T
Externí odkaz:
https://doaj.org/article/fff9a10cc1a745f58f879735bd89f47e
Autor:
Ivy Wang, Sandeep K. Gupta, Guillaume Ems, Nadishka Jayawardena, Mike Strauss, Mihnea Bostina
Publikováno v:
Viruses, Vol 14, Iss 2, p 318 (2022)
Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess the structural diversity of these picornaviruses.
Externí odkaz:
https://doaj.org/article/d3abafb3f30a4d4aa47d8c8957b95d01
Autor:
Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann, Katja Lammens
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mut
Externí odkaz:
https://doaj.org/article/22b52c92e3104c5888ae0b4dd5745f98
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Nucleosomes, the basic unit of chromatin, are repetitively spaced along DNA and regulate genome expression and maintenance. The long linear chromatin molecule is extensively condensed to fit DNA inside the nucleus. How distant nucleosomes in
Externí odkaz:
https://doaj.org/article/f602bcecdea24fc09731f8793c1cc913
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nucleosomes are dynamic and can move along DNA in an uncatalyzed manner but little is known about the mechanisms of histone octamer translocation. Here the authors present cryo-EM structures of nucleosomes in differently organized histone octamer and
Externí odkaz:
https://doaj.org/article/4b6d6997c4ab43a8a267659de1b41813