Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mike Sintchak"'
Autor:
Alfredo Csibi, Nello Mainolfi, Veronica Campbell, Bin Yang, Mike Sintchak, Michele Mayo, Sharon Townson, Sean Zhu, Haojing Rong, Hari Kamadurai, Henry Li, Phillip Liu, Anthony Slavin, Karen Yuan, Scott F. Rusin, Kirti Sharma, Chris De Savi, Nan Ji, Jared Gollob, Yogesh Chutake, Duncan Walker, Alice McDonald
Publikováno v:
Cancer Research. 80:LB-088
Signal transducer and activator of transcription 3 (STAT3) has been implicated in multiple aspects of tumorigenesis. In addition to increasing cancer cell proliferation and survival, constitutively activated STAT3 is proposed to regulate cross-talk b
Autor:
Sai M Pulukuri, James Minissale, Neil F. Bence, Matt Duffey, Hirotake Mizutani, He Xu, Hu Zhigen, Lawrence R. Dick, Xingyue He, Dylan England, Erik Koenig, Pooja Shah, Xiaofeng Yang, Hua Liao, Teresa A. Soucy, James E. Brownell, Melissa Gallery, Claudia Rabino, John Newcomb, Hugues Bernard, John Bradley, Jianping Guo, Mike Sintchak, Zhong-Hua Yan, Kristina Xega, Steve Langston, Ryan Chau, Jessica Riceberg, Eric S. Lightcap
Publikováno v:
Nature chemical biology. 13(11)
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a mechanism-bas
Autor:
Xiaofeng Yang, Michael Milhollen, Neil Bence, Mark Manfredi, Huay-Keng Loke, Erik Koenig, James E. Brownell, Mike Sintchak, Michael P. Thomas, Usha Narayanan, Qing Xu, James M. Gavin, Jessica Riceberg, Alice McDonald, Joseph B. Bolen, Benjamin S. Amidon, Peter G. Smith, Sells Todd B, Tary Traore, Jingya Ma, Lawrence R. Dick
Publikováno v:
Cancer cell. 21(3)
SummaryMLN4924 is an investigational small-molecule inhibitor of NEDD8-activating enzyme (NAE) in clinical trials for the treatment of cancer. MLN4924 is a mechanism-based inhibitor, with enzyme inhibition occurring through the formation of a tight-b
Autor:
Michael P. Thomas, Erik Koenig, Neil Bence, Usha Narayanan, Peter G. Smith, Sells Todd B, Mike Sintchak, Mark Manfredi, Jessica Riceberg, Michael Milhollen, Ben Amidon, Larry Dick, James E. Brownell, James M. Gavin, Tary Traore
Publikováno v:
Molecular Cancer Therapeutics. 10:C28-C28
MLN4924 is an investigational small molecule inhibitor of NEDD8-activating enzyme (NAE) that has shown clinical activity in Phase I clinical trials. MLN4924 is a mechanism-based inhibitor of NAE as demonstrated through the formation of a NEDD8-MLN492