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Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer's Aβ peptide

Autor: Maria Gregori, Mike Sherer, Vanessa Zambelli, Mark Taylor, Claire Louisa Tinker-Mill, Oleg Kolosov, Elisa Salvati, Claudia Balducci, Silvia Sesana, Gianluigi Forloni, David Allsop, Stephen Harris, Christos Michail, Francesca Re, Simona Mancini, Maria Michael, Nigel J. Fullwood, Massimo Masserini

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 13:723-732

Aggregation of amyloid-β peptide (Aβ) is a key event in the pathogenesis of Alzheimer's disease (AD). We investigated the effects of nanoliposomes decorated with the retro-inverso peptide RI-OR2-TAT (Ac-rGffvlkGrrrrqrrkkrGy-NH 2 ) on the aggregatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6e5d2bd794a44f197629de4d60122c
https://doi.org/10.1016/j.nano.2016.10.006

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A preliminary electron microscopic investigation into the interaction between Aβ1-42peptide and a novel nanoliposome- coupled retro-inverso peptide inhibitor, developed as a potential treatment for Alzheimer's disease

Autor: David Allsop, Mike Sherer, Mark Taylor, Nigel J. Fullwood

Publikováno v: Journal of Physics: Conference Series. 644:012040

Alzheimer's disease (AD) is a progressive neurodegenerative condition that results in severe cognitive and functional decline in sufferers and for which there are currently no effective treatments to halt or reverse disease progression. AD is the mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3527295da824a526c1e857d734fc8287
https://doi.org/10.1088/1742-6596/644/1/012040

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