Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mike Rees"'
Autor:
David Barros Aguirre, Lluis Ballell, Sarah M. Batt, Gurdyal S. Besra, John D. McKinney, Laura Vela-Glez Del Peral, Mike Rees, Bernadette Mouzon, Robert J. Young, Christopher D. Stubbs, Esther Pérez-Herrán, Julia Castro Pichel, Argyrides Argyrou, Jonathan P. Hutchinson, Neeraj Dhar, Monica Cacho Izquierdo
Publikováno v:
ACS Infectious Diseases. 1:615-626
We have targeted the Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose oxidase (Mt-DprE1) for potential chemotherapeutic intervention of tuberculosis. A multicopy suppression strategy that overexpressed Mt-DprE1 in M. bovis BCG was used to
Autor:
Angela Bridges, Mike Rees, Peter Francis, Argyrides Argyrou, Bill Leavens, Melanie Leveridge, Chun-wa Chung, P. Hardwicke, Andrew West, Rachel Buxton, Steven J. Ratcliffe
Publikováno v:
SLAS Discovery. 19:278-286
Using mass spectrometry to detect enzymatic activity offers several advantages over fluorescence-based methods. Automation of sample handling and analysis using platforms such as the RapidFire (Agilent Technologies, Lexington, MA) has made these assa
Autor:
Inigo Lopez De Cenarruzabeitia, Peter J. Friend, Charles Imber, Shawn D. St. Peter, Hugh Lemonde, Mike Rees, Andrew Butler, Peter E. Clayton
Machine perfusion of livers may provide a mechanism for extended preservation of marginal donor organs before transplantation, as well as a method for viability assessment. It has proved possible in a series of experimental porcine liver perfusions t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9285da34496be277baa473d0c38dbf19
https://ora.ox.ac.uk/objects/uuid:19dcc51b-dba6-4eae-8d38-ae0f64089c19
https://ora.ox.ac.uk/objects/uuid:19dcc51b-dba6-4eae-8d38-ae0f64089c19
Autor:
Eugenia Meiler, Minkui Luo, Madhumitha Nandakumar, Kenan C. Murphy, Thulasi Warrier, Mike Rees, Ben Gold, Carl Nathan, Argyrides Argyrou, Kyu Y. Rhee, Thomas R. Ioerger, Julia Roberts, Kanishk Kapilashrami, Tuo Zhang, Selin Somersan-Karakaya, Alfonso Mendoza-Losana, Yan Ling, David Little, María Martínez-Hoyos, Kristin Burns-Huang, Jianjie Mi, Suna Park, Esther Porras de Francisco
Significance Better understanding of the mechanisms used by bacteria to counter antibacterial agents is essential to cope with the rising prevalence of antimicrobial resistance. Here, we identified the mechanism of resistance of Mycobacterium tubercu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120e4dfa33e1ea22876432ad549b491c
https://europepmc.org/articles/PMC4978242/
https://europepmc.org/articles/PMC4978242/
Autor:
Phil Hardwicke, Luigi Piero Stasi, Melanie Leveridge, Alan Nadin, Alastair D. Reith, Colin M. Edge, Lee Collier, Bill Leavens, Steve Ratcliffe, Mike Rees
Publikováno v:
Journal of biomolecular screening. 21(2)
LRRK2 is a large multidomain protein containing two functional enzymatic domains: a GTPase domain and a protein kinase domain. Dominant coding mutations in the LRRK2 protein are associated with Parkinson's disease (PD). Among such pathogenic mutation
Autor:
Mike Rees, Jitesh Dineschandra
Publikováno v:
Health Care Management Science. 8:197-203
Methods of assessing and monitoring the performance of clinicians have received a lot of publicity in recent years. We review the main methodologies concentrating on the distinction between monitoring individual performance and monitoring aggregated
Autor:
Mike Rees
Publikováno v:
ITNOW. 58:64-64
Publikováno v:
CBMS
In this paper, we present a modelling framework for patient flow in a healthcare system using semi-open queueing network models, which introduces a total bed constraint, above which new patients will be refused admission. Hence this model provides a
Autor:
Jitesh Dineschandra, Mike Rees
Publikováno v:
CBMS
We present the need for risk stratification in the monitoring of cardiac surgical practice and review the frequentist and Bayesian approaches to the problem. Developments in the available databases are described. Enhancements to the Parsonnet and Eur