AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter

Autor: Gareth O. Griffiths, Richard FitzGerald, Thomas Jaki, Andrea Corkhill, Helen Reynolds, Sean Ewings, Susannah Condie, Emma Tilt, Lucy Johnson, Mike Radford, Catherine Simpson, Geoffrey Saunders, Sara Yeats, Pavel Mozgunov, Olana Tansley-Hancock, Karen Martin, Nichola Downs, Izabela Eberhart, Jonathan W. B. Martin, Cristiana Goncalves, Anna Song, Tom Fletcher, Kelly Byrne, David G. Lalloo, Andrew Owen, Michael Jacobs, Lauren Walker, Rebecca Lyon, Christie Woods, Jennifer Gibney, Justin Chiong, Nomathemba Chandiwana, Shevin Jacob, Mohammed Lamorde, Catherine Orrell, Munir Pirmohamed, Saye Khoo, on behalf of the AGILE investigators

Publikováno v: Trials, Vol 22, Iss 1, Pp 1-5 (2021)

Abstract Background There is an urgent unmet clinical need for the identification of novel therapeutics for the treatment of COVID-19. A number of COVID-19 late phase trial platforms have been developed to investigate (often repurposed) drugs both in

Externí odkaz: https://doaj.org/article/24657c03deb0425d9ec6d713b1197217

Uva-ursi extract and ibuprofen as alternative treatments of adult female urinary tract infection (ATAFUTI): study protocol for a randomised controlled trial

Autor: Jeanne Trill, Catherine Simpson, Frances Webley, Mike Radford, Louise Stanton, Tom Maishman, Angeliki Galanopoulou, Andrew Flower, Caroline Eyles, Merlin Willcox, Alastair Hay, Gareth Griffiths, Paul Little, George Lewith, Michael Moore

Publikováno v: Trials, Vol 18, Iss 1, Pp 1-9 (2017)

Abstract Background Women with acute uncomplicated urine infection are usually treated with antibiotics. One trial has demonstrated that delayed antibiotic treatment offered without symptom relief results in a modest reduction in antibiotic use. Ther

Externí odkaz: https://doaj.org/article/9376c3a0bbe342259d42105c3c3cd3b4

Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

Autor: Kim Mallard, William Greenhalf, Lauren Walker, Susannah Condie, Ellice Marwood, Michael Jacobs, Tom Fletcher, Gareth Griffiths, Geoffrey Saunders, Sean Ewings, Victoria Shaw, Richard Fitzgerald, Kerensa Thorne, Olana Tansley-Hancock, Andrew Owen, Lucy Johnson, Sara Yeats, David G. Lalloo, Wendy Painter, Helen Reynolds, Henry Pertinez, Thomas Jaki, Christie Woods, Keira Fines, Emma Wrixon, Colin Hale, Andrea Corkhill, Katie Bullock, Mike Radford, Emily R. Adams, Nichola Downs, Saye Khoo, Justin Chiong, Wayne Holman, Rebecca Lyon, Pavel Mozgunov, Marcin D Bula, Jennifer L Gibney

Publikováno v: The Journal of antimicrobial chemotherapy

Objectives AGILE is a Phase Ib/IIa platform for rapidly evaluating COVID-19 treatments. In this trial (NCT04746183) we evaluated the safety and optimal dose of molnupiravir in participants with early symptomatic infection. Methods We undertook a dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5576a4da8769d3c6064bde32dbfec8
https://eprints.soton.ac.uk/476394/

Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC):long-term results of a multicentre, randomised, controlled, phase 3 trial

Autor: Marjorie Tomlinson, Juan W. Valle, Meg Finch-Jones, O. James Garden, S Pugh, Tamas Hickish, Joanne Hornbuckle, Sharadah Essapen, Raaj K. Praseedom, Chan Ton, Marcia Hall, Alison Brewster, Sarah Smith, A Mayer, Nariman Karanjia, Stephen Falk, Nagappan Kumar, Mark A. Hill, Stephen Fenwick, Tim Maughan, John Bridgewater, Alison Brown, Sherif Raouf, Andrea Corkhill, Amy Whitehead, Vanessa Potter, Charlotte Rees, Tom Diamond, Ajith K. Siriwardena, David J. Smith, Susan Cleator, Charles Wilson, Sarah Slater, John N. Primrose, David Cunningham, Gareth Griffiths, Hassan Malik, Nasim Ali, Alex Allen, Christopher Baughan, Satya Bhattacharya, Timothy Iveson, Charles Lowdell, Satvinder Mudan, Brian R. Davidson, Louise Stanton, Paul Ross, Luke Nolan, Iain Cameron, Ann O'Callaghan, Robert J. Thomas, Ewan Brown, Tom Maishman, Anne Moody, Sally Clive, Clare Barlow, Mike Radford, Nua Chan Ton, Georgina Walker, David Tsang, Derek A. O'Reilly, Alaaeldin Shablack, Colin Purcell, Mark Peterson, Zina Eminton, Myrddin Rees, Nigel Heaton, Jane Mellor

Publikováno v: New EPOC investigators 2020, ' Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC) : long-term results of a multicentre, randomised, controlled, phase 3 trial ', The Lancet Oncology, vol. 21, no. 3, pp. 398-411 . https://doi.org/10.1016/S1470-2045(19)30798-3
The Lancet. Oncology

Background: The interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction in progression-free survival in patients allocated to cetuximab plus chemotherapy compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1626d37868998ab4d8cd96edfc217e80
https://doi.org/10.1016/S1470-2045(19)30798-3

Uva-Ursi Extract and Ibuprofen as Alternative Treatments of Adult Female Uncomplicated Urinary Tract Infection (Atafuti): A Double-Blind, Placebo-Controlled, Factorial Randomised Trial, and Open Pragmatic Trial

Autor: Louise Stanton, Jeanne Trill, Micheal Moore, Mike Radford, Andrew Flower, Gareth Griffiths, Merlin Willcox, Tom Maishman, Esther T van der Werf, Simon Gibbons, Paul Little, Frances Webley, Caroline Eyles, Catherine Simpson, George Lewith, Angeliki Galanopoulou, Alastair D Hay

Publikováno v: SSRN Electronic Journal.

Background: To investigate if offering symptomatic therapy alongside a delayed prescription would relieve symptoms and reduce the consumption of antibiotics for adult women presenting with acute uncomplicated urinary tract infection (UTI). Methods: A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d0bbde33604a6f7bf74099722de6062
https://doi.org/10.2139/ssrn.3216860