Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Mike O Karl"'
Autor:
Yu Zhu, Madalena Carido, Andrea Meinhardt, Thomas Kurth, Mike O Karl, Marius Ader, Elly M Tanaka
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54552 (2013)
A goal in human embryonic stem cell (hESC) research is the faithful differentiation to given cell types such as neural lineages. During embryonic development, a basement membrane surrounds the neural plate that forms a tight, apico-basolaterally pola
Externí odkaz:
https://doaj.org/article/5f438b1513814cf78feca0375ccbd504
Autor:
Branden R Nelson, Yumi Ueki, Sara Reardon, Mike O Karl, Sean Georgi, Byron H Hartman, Deepak A Lamba, Thomas A Reh
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22817 (2011)
Previous studies have shown that Müller glia are closely related to retinal progenitors; these two cell types express many of the same genes and after damage to the retina, Müller glia can serve as a source for new neurons, particularly in non-mamm
Externí odkaz:
https://doaj.org/article/e5ac9243eca14e74a3cd7a08e853bc23
Autor:
Madalena Carido, Manuela Völkner, Lisa Maria Steinheuer, Felix Wagner, Thomas Kurth, Natalie Dumler, Selen Ulusoy, Stephanie Wieneke, Anabel Villanueva Norniella, Cristina Golfieri, Shahryar Khattak, Bruno Schönfelder, Maria Scamozzi, Katja Zoschke, Sebastian Canzler, Jörg Hackermüller, Marius Ader, Mike O. Karl
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The possible applications for human retinal organoids (HROs) derived from human induced pluripotent stem cells (hiPSC) rely on the robustness and transferability of the methodology for their generation. Standardized strategies and parameters to effec
Externí odkaz:
https://doaj.org/article/11c92076dd06422d8dbd23b2ba307247
Autor:
Manuela Völkner, Felix Wagner, Thomas Kurth, Alex M. Sykes, Claudia Del Toro Runzer, Lynn J. A. Ebner, Cagri Kavak, Vasileia Ismini Alexaki, Peter Cimalla, Mirko Mehner, Edmund Koch, Mike O. Karl
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research. However, to which extent differential neuronal and glial pathologic proc
Externí odkaz:
https://doaj.org/article/b6df85ddea224a268d9f688df0becab5
Autor:
Seba Almedawar, Katerina Vafia, Sven Schreiter, Katrin Neumann, Shahryar Khattak, Thomas Kurth, Marius Ader, Mike O. Karl, Stephen H. Tsang, Elly M. Tanaka
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 374-389 (2020)
Summary: Maintenance of a healthy photoreceptor-retinal pigment epithelium (RPE) interface is essential for vision. At the center of this interface, apical membrane protrusions stemming from the RPE ensheath photoreceptor outer segments (POS), and ar
Externí odkaz:
https://doaj.org/article/8b4e7ca095974d759b07ac1e0822839f
Autor:
Manuela Völkner, Marlen Zschätzsch, Maria Rostovskaya, Rupert W. Overall, Volker Busskamp, Konstantinos Anastassiadis, Mike O. Karl
Publikováno v:
Stem Cell Reports, Vol 6, Iss 4, Pp 525-538 (2016)
The plasticity of pluripotent stem cells provides new possibilities for studying development, degeneration, and regeneration. Protocols for the differentiation of retinal organoids from embryonic stem cells have been developed, which either recapitul
Externí odkaz:
https://doaj.org/article/e3aa552620084479a3c39ec0e2ee5f18
Publikováno v:
Adaptive Optics and Wavefront Control for Biological Systems IX.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b5245b85428efc30fb00f80931912a5
https://doi.org/10.1117/12.2661936
https://doi.org/10.1117/12.2661936
Autor:
Felix Wagner, Roberto Carrera, Thomas Kurth, Stylianos Michalakis, Ronald Naumann, Marta Zuzic, Katrin Neumann, Olivier Gourau, Volker Busskamp, Mike O. Karl
Cell transplantation is a promising therapeutic approach to recover loss of neurons and vision in patient retinas. So far, human photoreceptor transplants restored some visual function in degenerating mouse retina. Whether retinal cell transplants al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3e125b360ad0de9d51098b6743e93fb
https://doi.org/10.1101/2022.08.09.500037
https://doi.org/10.1101/2022.08.09.500037
Publikováno v:
Biomedical Spectroscopy, Microscopy, and Imaging II.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2628450e44388798257b19988aebbbc
https://doi.org/10.1117/12.2622155
https://doi.org/10.1117/12.2622155
Autor:
Katerina Vafia, Marius Ader, Elly M. Tanaka, Rico Barsacchi, Mike O. Karl, Sven Schreiter, Seba Almedawar, Stephen H. Tsang, Marc Bickle
Publikováno v:
Stem Cell Reports
Stem cell reports 15(6), 1347-1361 (2020). doi:10.1016/j.stemcr.2020.10.013
Stem cell reports 15(6), 1347-1361 (2020). doi:10.1016/j.stemcr.2020.10.013
Summary Phagocytosis is a key function in various cells throughout the body. A deficiency in photoreceptor outer segment (POS) phagocytosis by the retinal pigment epithelium (RPE) causes vision loss in inherited retinal diseases and possibly age-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644644442a10dcf23eed5900b6fde9a9
https://doi.org/10.1016/j.stemcr.2020.10.013
https://doi.org/10.1016/j.stemcr.2020.10.013