Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mike Matles"'
Autor:
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M Brendza, Todd C Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H Tay, William E Delaney, Gregory T Notte, Uli Schmitz, Becket Feierbach
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0271145 (2022)
Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis B virus (HBV) infection, we performed a focused screen of epigenet
Externí odkaz:
https://doaj.org/article/f4644c5b4458489dba69140ec4acc22c
Autor:
Kelly Wang, James G. Taylor, Elsa Mondou, Mike Matles, Yang Zheng-Yu, Yujin Wang, Hongtao Liu, Jianyu Sun, Yang Tian, Guofeng Cheng, Hongyan Guo, Lianhong Xu, Melanie Cornpropst, Jason K. Perry, Michael L. Mitchell, Thorsten Kirschberg, Kato Darryl, Manoj C. Desai, Chris Yang, Neil H. Squires, John O. Link, Terry Kellar, Erik Mogalian, Jay P. Parrish
Publikováno v:
Journal of Medicinal Chemistry. 57:2033-2046
A new class of highly potent NS5A inhibitors with an unsymmetric benzimidazole-difluorofluorene-imidazole core and distal [2.2.1]azabicyclic ring system was discovered. Optimization of antiviral potency and pharmacokinetics led to the identification
Autor:
Jennifer Tang, Bernard P. Murray, Lazerwith Scott E, Peter Pyun, Morganelli Philip Anthony, Jianhong Wang, Gene Eisenberg, Heather Zhang, Haolun Jin, Gerry Rhodes, Kelly Wang, Joseph M. Custodio, Mike Matles, Judy Mwangi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S26-S27
Autor:
Daniel Byun, Yu-Jen Lee, Willard Lew, Lazerwith Scott E, Zhang Jennifer R, Eric Mabery, Lee Chong, Eda Canales, Mertzman Michael E, Edward Doerffler, Lianhong Xu, Todd Appleby, Martijn Fenaux, Jingyu Zhang, Hashash Ahmad, William J. Watkins, Judy Mwangi, Morganelli Philip Anthony, Liu Qi, Bernard P. Murray, Xiaowu Chen, Christine Zhu, Michael O'neil Hanrahan Clarke, Yang Tian, Mike Matles, Hong Ye, Stephanie A. Leavitt
Publikováno v:
Journal of medicinal chemistry. 57(5)
Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure–activity relationships for intrinsic cellular potency. The pharmacokinetic profile was enhanced t
Autor:
Martijn Fenaux, Stacey Eng, Stephanie A. Leavitt, Yu-Jen Lee, Eric M. Mabery, Yang Tian, Daniel Byun, Eda Canales, Michael O. Clarke, Edward Doerffler, Scott E. Lazerwith, Willard Lew, Qi Liu, Michael Mertzman, Philip Morganelli, Lianhong Xu, Hong Ye, Jennifer Zhang, Mike Matles, Bernard P. Murray, Judy Mwangi, Jingyu Zhang, Ahmad Hashash, Steve H. Krawczyk, Alison M. Bidgood, Todd C. Appleby, William J. Watkins
GS-9669 is a highly optimized thumb site II nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, with a binding affinity of 1.35 nM for the genotype (GT) 1b protein. It is a selective inhibitor of HCV RNA replication, with a mean 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d66793ecfe602fea0d21fe4a59c1e4
https://europepmc.org/articles/PMC3553741/
https://europepmc.org/articles/PMC3553741/
Autor:
John O, Link, James G, Taylor, Lianhong, Xu, Michael, Mitchell, Hongyan, Guo, Hongtao, Liu, Darryl, Kato, Thorsten, Kirschberg, Jianyu, Sun, Neil, Squires, Jay, Parrish, Terry, Kellar, Zheng-Yu, Yang, Chris, Yang, Mike, Matles, Yujin, Wang, Kelly, Wang, Guofeng, Cheng, Yang, Tian, Erik, Mogalian, Elsa, Mondou, Melanie, Cornpropst, Jason, Perry, Manoj C, Desai
Publikováno v:
Journal of Medicinal Chemistry. 59:7696-7696
Autor:
Robert G. Strickley, Yujin Wang, Jaclyn Hayes, Michael L. Mitchell, Jennifer R. Zhang, Michael O'neil Hanrahan Clarke, Liu Qi, Margaret Robinson, Weidong Zhong, Edward Doerffler, Megan Tessler, Gina Bahador, Lazerwith Scott E, Lee Chong, Mike Matles, Neeraj Tirunagari, Jianhong Wang, Bernard P. Murray, Morganelli Philip Anthony, Xubin Zheng, Eugene J. Eisenberg, Bing Lu, Guofeng Cheng, Eda Canales, Mertzman Michael E, William J. Watkins
Publikováno v:
ACS medicinal chemistry letters. 2(10)
A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochemical properties and PK were identified and exploited to guide the design of
Autor:
Edward Doerffler, Morganelli Philip Anthony, Todd Appleby, Martijn Fenaux, Daniel Byun, Lazerwith Scott E, Stephanie A. Leavitt, Yun Tian, Jennifer Zhang, Steven H. Krawczyk, Eric Mabery, E. Canales, Will Watkins, Judy Mwangi, A. M. Bidgood, Michael O'neil Hanrahan Clarke, Bernard P. Murray, Hong Ye, Jingyu Zhang, Mike Matles, Hashash Ahmad, S. Eng, Mertzman Michael E, Willard Lew, Qui Liu
Publikováno v:
Journal of Hepatology. 54:S476