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Autor:
Tico S. Thepsourinthone, Paul D. Boucher, Brendon Ladd, Sheryl A. Flanagan, Donna S. Shewach, John A. Secrist, Mike M. Im, Jessica J. O’Konek
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 684:1-10
Nucleoside analogs are efficacious cancer chemotherapeutics due to their incorporation into tumor cell DNA. However, they exhibit vastly different antitumor efficacies, suggesting that incorporation produces divergent effects on DNA replication. Here