Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mike Fernandez"'
Autor:
Martina Cusan, Haifeng Shen, Bo Zhang, Aijun Liao, Lu Yang, Meiling Jin, Mike Fernandez, Prajish Iyer, Yiming Wu, Kevyn Hart, Catherine Gutierrez, Sara Nik, Shondra M. Pruett-Miller, Jeremy Stark, Esther A. Obeng, Teresa V. Bowman, Catherine J. Wu, Ren-Jang Lin, Lili Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion in B cells, but not either lesion alone, leads to the onset of
Externí odkaz:
https://doaj.org/article/2342ae1271db4cc3a65ea43ea203cc65
Autor:
Yiming Wu, Meiling Jin, Mike Fernandez, Kevyn L. Hart, Aijun Liao, Xinzhou Ge, Stacey M. Fernandes, Tinisha McDonald, Zhenhua Chen, Daniel Röth, Lucy Y. Ghoda, Guido Marcucci, Markus Kalkum, Raju K. Pillai, Alexey V. Danilov, Jingyi Jessica Li, Jianjun Chen, Jennifer R. Brown, Steven T. Rosen, Tanya Siddiqi, Lili Wang
Publikováno v:
Blood Cancer Discovery. 4:228-245
RNA splicing dysregulation underlies the onset and progression of cancers. In chronic lymphocytic leukemia (CLL), spliceosome mutations leading to aberrant splicing occur in ∼20% of patients. However, the mechanism for splicing defects in spliceoso
Autor:
Lili Wang, Tanya Siddiqi, Steven T. Rosen, Jennifer R. Brown, Jianjun Chen, Jingyi Jessica Li, Alexey V. Danilov, Raju K. Pillai, Markus Kalkum, Guido Marcucci, Lucy Y. Ghoda, Daniel Röth, Zhenhua Chen, Tinisha McDonald, Stacey M. Fernandes, Xinzhou Ge, Aijun Liao, Kevyn L. Hart, Mike Fernandez, Meiling Jin, Yiming Wu
Fig S1. SF3B1 mutant CLL samples had pervasive changes in 3’ splice site. Fig S2. Omics analyses identify widespread post-transcriptional upregulation of splicing factors in CLL. Fig S3. Abundance of spliceosome complexes and RNA-binding proteins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731b0511ef858cdcd0980d89ebbc9c1a
https://doi.org/10.1158/2643-3230.22645217
https://doi.org/10.1158/2643-3230.22645217
Autor:
Lili Wang, Tanya Siddiqi, Steven T. Rosen, Jennifer R. Brown, Jianjun Chen, Jingyi Jessica Li, Alexey V. Danilov, Raju K. Pillai, Markus Kalkum, Guido Marcucci, Lucy Y. Ghoda, Daniel Röth, Zhenhua Chen, Tinisha McDonald, Stacey M. Fernandes, Xinzhou Ge, Aijun Liao, Kevyn L. Hart, Mike Fernandez, Meiling Jin, Yiming Wu
RNA splicing dysregulation underlies the onset and progression of cancers. In chronic lymphocytic leukemia (CLL), spliceosome mutations leading to aberrant splicing occur in ∼20% of patients. However, the mechanism for splicing defects in spliceoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a5d650883778aa792bb8a1f69dd477
https://doi.org/10.1158/2643-3230.c.6603185.v1
https://doi.org/10.1158/2643-3230.c.6603185.v1
Autor:
Lili Wang, Tanya Siddiqi, Steven T. Rosen, Jennifer R. Brown, Jianjun Chen, Jingyi Jessica Li, Alexey V. Danilov, Raju K. Pillai, Markus Kalkum, Guido Marcucci, Lucy Y. Ghoda, Daniel Röth, Zhenhua Chen, Tinisha McDonald, Stacey M. Fernandes, Xinzhou Ge, Aijun Liao, Kevyn L. Hart, Mike Fernandez, Meiling Jin, Yiming Wu
Table S1 shows CLL sample information; Table S2 shows protein expression detected in CLL and normal B cells using TMT proteomics; Table S3 shows top 150 transcripts with highest m6A density in B cells; Table S4 shows sequences of shRNAs, sgRNAs, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b3c15566f7d9d7e875e52b3e8dee19
https://doi.org/10.1158/2643-3230.22645214
https://doi.org/10.1158/2643-3230.22645214
Autor:
Yiming Wu, Meiling Jin, Mike Fernandez, Kevyn Hart, Aijun Liao, Stacey M. Fernandes, Tinisha McDonald, Zhenhua Chen, Daniel Röth, Lucy Ghoda, Guido Marcucci, Markus Kalkum, Raju K. Pillai, Alexey V. Danilov, Jianjun Chen, Jennifer R. Brown, Steven T. Rosen, Tanya Siddiqi, Lili Wang
Publikováno v:
Cancer Research. 83:3482-3482
RNA splicing dysregulation is a hallmark of cancers and underlies the onset and progression of diseases. Chronic lymphocytic leukemia (CLL) is one of the most common adult leukemia in western countries. Spliceosome mutations occur in ~20% of patients
Autor:
Martina Cusan, Meiling Jin, Bo Zhang, Mike Fernandez, Aijun Liao, Lu Yang, Yiming Wu, Prajish Iyer, Kevyn Hart, Catherine Gutierrez, Jeremy Stark, Teresa V. Bowman, Catherine J. Wu, Ren-Jang Lin, Lili Wang
Publikováno v:
Blood. 138:3713-3713
The RNA splicing factor SF3B1 is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL). Co-expression of mutant Sf3b1 and Atm deletionin murine B cellsresults in CLL development, in which CLL cells exhibit RNA splicing dysreg
Autor:
Tinisha McDonald, Lucy Ghoda, Alexey V. Danilov, Stacey M. Fernandes, Meiling Jin, Aijun Liao, Jianjun Chen, Lili Wang, Raju Pillai, Markus Kalkum, Steven T. Rosen, Jennifer R. Brown, Mike Fernandez, Yiming Wu, Kevyn Hart, Tanya Siddiqi, Daniel Roeth
Publikováno v:
Blood. 138:499-499
RNA splicing dysregulation is a hallmark of chronic lymphocytic leukemia (CLL). Although somatic mutations in SF3B1 or U1 snRNA present in >20% of CLL patients, general splicing defects cannot be fully explained by genetic alterations of spliceosome
Publikováno v:
Energy Procedia. 37:7709-7722
This paper presents the approach being taken by the Province of Alberta (Canada) to assess the site specific risks of carbon dioxide (CO2) sequestration and how the long-term liability associated with such activities will be managed. This paper highl