Výsledky vyhledávání - "Mike F. Hughes"

Ran alters nuclear pore complex conformation

Autor: Laura A Cotter, Steven Bagley, Paul Clarke, Elena Kiseleva, Martin W. Goldberg, Mike F. Hughes, Terence D Allen, Sandra A Rutherford

Publikováno v: Journal of Molecular Biology. 300:519-529

Transport across the nuclear membranes occurs through the nuclear pore complex (NPC), and is mediated by soluble transport factors including Ran, a small GTPase that is generally GDP-bound during import and GTP-bound for export. The dynamic nature of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7786118694f89530ff3b30a9ffc06a2b
https://doi.org/10.1006/jmbi.2000.3891

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Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

Autor: Mike F. Hughes, Paul Clarke, Chuanmao Zhang

Publikováno v: Journal of Cell Science. 112:2453-2461

Ran is an abundant GTPase of the Ras superfamily that is highly conserved in eukaryotes. In interphase cells, Ran is mainly nuclear and thought to be predominantly GTP-bound, but it is also present in the cytoplasm, probably GDP-bound. This asymmetri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78067f6c62b09afd8bb058ee77d3a92b
https://doi.org/10.1242/jcs.112.14.2453

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Changes of Mitochondrial Mass in the Hemopoietic Stem Cell Line FDCP-Mix after Treatment with Etoposide: A Correlative Study by Multiparameter Flow Cytometry and Confocal and Electron Microscopy

Autor: Terence D Allen, John A. Hickman, Jeff Berry, Siegfried Reipert, Mike F. Hughes

Publikováno v: Experimental Cell Research. 221:281-288

FDCP-Mix, a pluripotent murine hemopoietic stem cell line which undergoes typical internucleosomal cleavage of DNA when induced to apoptosis by either drugs or withdrawal of growth factor (interleukin-3) was studied after treatment with the topoisome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c64046fada7877ecc2243a7a5920bdc
https://doi.org/10.1006/excr.1995.1376

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Substrate specificity determinants of the checkpoint protein kinase Chk1

Autor: Paul Clarke, Mike F. Hughes, James R. A. Hutchins

Publikováno v: FEBS Letters. (1):91-95

The Chk1 protein kinase plays a critical role in a DNA damage checkpoint pathway conserved between fission yeast and animals. We have developed a quantitative assay for Chk1 activity, using a peptide derived from a region of Xenopus Cdc25C containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6c215ab20e471a03075ad78b323661

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