Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development.

Autor: Mike F Müller, Simone Florian, Stefanie Pommer, Martin Osterhoff, R Steven Esworthy, Fong-Fong Chu, Regina Brigelius-Flohé, Anna P Kipp

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72055 (2013)

The selenoprotein glutathione peroxidase-2 (GPx2) appears to have a dual role in carcinogenesis. While it protected mice from colon cancer in a model of inflammation-triggered carcinogenesis (azoxymethane and dextran sodium sulfate treatment), it pro

Externí odkaz: https://doaj.org/article/4196b780d9e84b638f831001aafcab3f

Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells

Autor: René Thierbach, Katrin Kühn, Stefanie Deubel, Anna P. Kipp, Mike F. Müller, Doerte Hoelzer, Martin Bertz, Solveigh C. Koeberle, Karolin Thies

Publikováno v: Free radical biologymedicine. 127

Selenoprotein H (SELENOH) is supposed to be involved in redox regulation as well as in tumorigenesis. However, its role in healthy and transformed cells of the gastrointestinal tract remains elusive. We analyzed SELENOH expression in cells depending

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e609983dea0917375fc398de7086f2d3
https://pubmed.ncbi.nlm.nih.gov/29330096

Molecular pathological classification of colorectal cancer

Autor: Mark J. Arends, Ashraf E.K. Ibrahim, Mike F. Müller

Publikováno v: Virchows Archiv
Müller, M-F, Ibrahim, A E & Arends, M 2016, ' Molecular Pathological Classification of Colorectal Cancer ', Virchows Archiv, pp. 125-34 . https://doi.org/10.1007/s00428-016-1956-3

Colorectal cancer (CRC) shows variable underlying molecular changes with two major mechanisms of genetic instability: chromosomal instability and microsatellite instability. This review aims to delineate the different pathways of colorectal carcinoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b079255c73c085dcfe4c711a7cf6b80
https://pubmed.ncbi.nlm.nih.gov/27325016

Nrf2 target genes are induced under marginal selenium-deficiency

Autor: Antje Banning, Anna P. Kipp, Mike F. Müller, Regina Brigelius-Flohé

Publikováno v: Genes & Nutrition. 5:297-307

A suboptimal selenium supply appears to prevail in Europe. The current study, therefore, was focused on the changes in gene expression under a suboptimal selenium intake. Previous microarray analyses in the colon of mice fed either a selenium-adequat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407939951a991ee2841d792a93206bbd
https://doi.org/10.1007/s12263-010-0168-8

The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis

Autor: Regina Brigelius-Flohé, Doris Lippmann, Mike F. Müller, Anna P. Kipp

Publikováno v: International Journal of Cell Biology
International Journal of Cell Biology, Vol 2012 (2012)

The NF-E2-related factor-2 (Nrf2) is a transcription factor which regulates the major cellular defense systems and thereby contributes to the prevention of many diseases including cancer. Selenium deficiency is associated with a higher cancer risk ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ec53512f69747bee5e4635e64ec69c
http://europepmc.org/articles/PMC3357939