Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mike Essl"'
Autor:
Thomas D. Schreiber, Carolin Steinl, Mike Essl, Harald Abele, Konstanze Geiger, Claudia A. Müller, Wilhelm K. Aicher, Gerd Klein
Publikováno v:
Haematologica, Vol 94, Iss 11 (2009)
Background Hematopoietic stem and progenitor cells can interact with their microenvironment via integrins which are adhesion receptors consisting of α and β subunits. Current knowledge suggests that the integrin subunits α4 and α6 expressed on he
Externí odkaz:
https://doaj.org/article/c7c13247f4fe490289ff46c2366ea4c7
Autor:
Lilia Goudeva, Fanni Kubaink, Jana Leise, Wolfgang Glienke, Andrew Kaiser, Hinrich Abken, Mike Essl, Ruth Esser, Andreas Hombach, Marion Jurk, Lubomir Arseniev, Murat Aktas, Krasimira Aleksandrova, Ulrike Köhl, Georg Rauser, Iris Bürger, Christoph Priesner, Anette Melk
Publikováno v:
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie. 46(1)
Clinical studies using autologous CAR T cells have achieved spectacular remissions in refractory CD19+ B cell leukaemia, however some of the patient treatments with CAR T cells failed. Beside the heterogeneity of leukaemia, the distribution and senes
Autor:
Boro Dropulic, Dmitry Litvinov, Yakov Muzalevsky, Galina Novichkova, Regina Alex, Alexander Karachunskiy, Mike Essl, Alexander Popov, Olga Molostova, Larisa Shelikhova, Rimas Orentas, Michael Maschan, Dmitriy Pershin, Dina Shneider, Elena Kurnikova, Alexey Maschan, Alexey Kazachenok, Natalia Miakova
Publikováno v:
Blood. 132:5202-5202
Introduction CD19 CAR-T cell products were recently approved as therapy for advanced B-cell lineage malignancies. The predominant manufacturing model for this type of therapy is a centralized industrial-type production process. An attractive model of
Autor:
Stefan Miltenyi, Jessica Blaschke, Juliane Stuth, Dirk Balshüsemann, Sabine Müller, Elmar Fahrendorff, Eiad Kabaha, Iris Spiegel, Jürgen Schmitz, Volker Huppert, Michael Apel, Mareke Brüning, Mike Essl, Markus Granzin
Publikováno v:
Chemie Ingenieur Technik. 85:103-110
Manufacturing of cellular products for therapeutic purposes like stem cell or cancer therapy requires equipment with specific characteristics not always addressed by conventional technologies. A new integrated cell processing device is presented that
Autor:
Belinda Stock, Halvard Bonig, Christiane Hümmer, Volker Huppert, Eva Wingenfeld, Mike Essl, Kristina Reck, Juliane Stuth, Erhard Seifried, Milica Bunos, Carolin Poppe
Publikováno v:
Journal of Translational Medicine
Background Automation of cell therapy manufacturing promises higher productivity of cell factories, more economical use of highly-trained (and costly) manufacturing staff, facilitation of processes requiring manufacturing steps at inconvenient hours,
Autor:
Sonja P. Hergeth, Gerd Klein, Mike Essl, Wilhelm K. Aicher, Takako Sasaki, Thomas D. Schreiber
Publikováno v:
Experimental Hematology. 36:1022-1034
Objective In the bone marrow stem cell niche, osteoblasts lining the endosteum are of major importance in supporting hematopoietic stem cell maintenance. Our objective was to analyze expression of the fibulins, highly conserved calcium-binding glycop
Autor:
Christiane Hümmer, Halvard-Björn Bönig, Gabriele Spohn, Volker Huppert, Erhard Seifried, Kristina Reck, Juliane Stuth, Eva Wingenfeld, Eliza Wiercinska, Mike Essl, Nadine Sorg, Darja Karpova, Milica Bunos, Carolin Poppe
Background aims Immunomagnetic enrichment of CD34+ hematopoietic "stem" cells (HSCs) using paramagnetic nanobead coupled CD34 antibody and immunomagnetic extraction with the CliniMACS plus system is the standard approach to generating T-cell-depleted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e345ccb1c28c8773f4a5bc77d3f92184
http://publikationen.ub.uni-frankfurt.de/files/40137/1-s2.0-S1465324915008580-main.pdf
http://publikationen.ub.uni-frankfurt.de/files/40137/1-s2.0-S1465324915008580-main.pdf
Autor:
Kristina Reck, Ian C.D. Johnston, Raisa Jofra Hernandez, Chiara Bovolenta, Samantha Scaramuzza, Constanze Lehmann, Alessandro Aiuti, Mike Essl, Simona La Seta Catamancio
Publikováno v:
Molecular Therapy. 23
Hereditary genetic disorders have been shown to be effectively treated by re-introduction of the wild-type gene product via viral modification of autologous CD34+ progenitor cells. However, current manufacturing processes are performed manually or at
Autor:
Eva Tolosa, Gerd Klein, Claudia A. Müller, Lydia Sorokin, Mike Essl, Heinz Schwarz, Michael Sixt, York-Dieter Stierhof, Dieter P. Reinhardt, Johannes T. Wessels, Mihaela Drumea-Mirancea, Johannes A. Eble, Manuel Koch
Publikováno v:
Journal of Cell Science. 119:1396-1405
T cells develop in the thymus in a highly specialized cellular and extracellular microenvironment. The basement membrane molecule, laminin-5 (LN-5), is predominantly found in the medulla of the human thymic lobules. Using high-resolution light micros
Autor:
Lea Prokop, Harald Abele, Johannes T. Wessels, Oliver Pötz, Wilhelm K. Aicher, Mike Essl, Carolin Steinl, Gerd Klein, Stefan Stevanovic, Thomas D. Schreiber, Konstanze Geiger
Publikováno v:
Stem cells and development. 22(9)
Previous studies indicate that the release of proteases, including the gelatinase matrix metalloproteinase (MMP)-9, from mature granulocytes plays a crucial role in cytokine-induced hematopoietic stem and progenitor cell (HSPC) mobilization. However,