Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mike D. Barker"'
Autor:
Angela Bridges, Bhumika Karamshi, Roy Katso, Laurie J. Gordon, Kirsty Gill, Alpa Mulji, Laurens Kruidenier, Emma J. Jones, Julia Smith, Robert Tanner, Fiona Brown, Mike D. Barker, Joanna Taylor, Arshad Sheikh, Sue Hutchinson, Rob Jepras, Rebecca Randle, Mike Woodrow, Melanie Leveridge, Murray J. B. Brown, John Liddle, Jordi Munoz-Muriedas, Penny A. Smee, Robert Eagle, Carl Haslam, Margaret Martin, Pamela Thomas
Publikováno v:
SLAS Discovery. 17:108-120
The biological complexity associated with the regulation of histone demethylases makes it desirable to configure a cellular mechanistic assay format that simultaneously encompasses as many of the relevant cellular processes as possible. In this repor
Publikováno v:
Tetrahedron. 62:11663-11669
Various cyclic meso -imides have been desymmetrised via enantioselective reduction using two chiral oxazaborolidine catalysts derived from (1 R ,2 S )- cis -1-amino-indan-2-ol followed by the reduction of the hydroxylactam product to give the γ-lact
Autor:
Melanie Washington, Davina Humphreys, Lesley Nisbet, Philip Alan Skone, Royston C. B. Copley, Simon J. F. Macdonald, Graham G. A. Inglis, Richard J. Upton, Mike D. Barker, Margaret Clackers, Victoria Vinader, Haydn Terence Jones, Michael John Johnston, Iain M. McLay, Derek A. Demaine, Stephen E. Shanahan, David House, Richard Loiseau, Dan Tape, Michael V. Haase, Francois Pacquet, Iain Uings
Publikováno v:
Journal of Medicinal Chemistry. 49:4216-4231
The tetrahydronaphthalene-benzoxazine glucocorticoid receptor (GR) partial agonist 4b was optimized to produce potent full agonists of GR. Aromatic ring substitution of the tetrahydronaphthalene leads to weak GR antagonists. Discovery of an "agonist
Publikováno v:
Organic letters. 16(14)
A highly enantioselective (95% ee) strategy to affect the desymmetrization of a maleimide has been performed by temporary attachment to an anthracene template followed by asymmetric reduction with an oxazaborolidine catalyst. A stereoablative over-re
Publikováno v:
ChemInform. 39
Kinetic resolution of racemic C-3 substituted pyrrolidine-2,5-diones has been achieved for the first time using highly efficient oxazaborolidine catalysts derived from cis-1-amino-indan-2-ol.
Publikováno v:
Chemical communications (Cambridge, England). (19)
Kinetic resolution of racemic C-3 substituted pyrrolidine-2,5-diones has been achieved for the first time using highly efficient oxazaborolidine catalysts derived from cis-1-amino-indan-2-ol.
Autor:
Simon J. F. Macdonald, Michael John Johnston, Mike D. Barker, Amanda Morris, Jonathon Hacon, Stephen E. Shanahan, Graham G. A. Inglis
Publikováno v:
ChemInform. 38
Reactions and purifications, including carbon-carbon bond forming reactions, can be carried out on a cellulose support on which the substrates are non-covalently absorbed.
Publikováno v:
ChemInform. 38
Autor:
Victoria Vinader, Davina Humphreys, Philip Alan Skone, Iain M. McLay, John Martin Pritchard, Derek A. Demaine, Michael John Johnston, Stephen E. Shanahan, Haydn Terence Jones, Mark Salter, Francois Pacquet, Iain Uings, Simon J. F. Macdonald, Mike D. Barker, Margaret Clackers
Publikováno v:
Journal of medicinal chemistry. 48(14)
Structurally related glucocorticoid receptor (GR) binders were docked into the GR active site to select the binding mode closest to the true docking mode. This process, termed an “agreement docking method”, led to the design of tetrahydronaphthal
Autor:
Jonathon Hacon, Amanda Morris, Michael J. Johnston, Stephen E. Shanahan, Mike D. Barker, Graham G. A. Inglis, Simon J. F. Macdonald
Publikováno v:
Chemical Communications; Jan2007, Vol. 2007 Issue 6, p625-627, 3p