Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Mike C. L. Wu"'
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Akademický článek
Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles
Autor: Chaohao Chen, Fan Wang, Shihui Wen, Qian Peter Su, Mike C. L. Wu, Yongtao Liu, Baoming Wang, Du Li, Xuchen Shan, Mehran Kianinia, Igor Aharonovich, Milos Toth, Shaun P. Jackson, Peng Xi, Dayong Jin
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Upconversion nanoparticles offer the potential for deep tissue biological imaging. Here, Chen et al. develop super resolution optical imaging in the near-infrared for imaging with sub-50 nm resolution through almost 100 microns of tissue.
Externí odkaz: https://doaj.org/article/10df58618a154e5fb4692631c30b4989
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2
Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods
Autor: Mike C. L. Wu, Imala Alwis, Richard J. Payne, Pedro Pereira, Shaun P. Jackson, Emma E. Watson, Jorge Ripoll-Rozada, Stijn M. Agten, Luke J. Dowman
Publikováno v: Angewandte Chemie-International Edition, 60(10), 5348-5356. Wiley-VCH Verlag
Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by binding to the active
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b8ae05a719d1ad3bf8caa24794e3ba
https://doi.org/10.1002/anie.202015127
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4
Rapid assembly and profiling of an anticoagulant sulfoprotein library
Autor: Ashley Lee, Tim Pasch, Charlotte Franck, Shaun P. Jackson, Emma E. Watson, Jessica Sayers, Bhavesh Premdjee, Pedro M. Martins, Pedro Pereira, Jorge Ripoll-Rozada, Richard J. Payne, Mike C. L. Wu, Maria Filipa Pinto
Publikováno v: Proceedings of the National Academy of Sciences. 116:13873-13878
Hematophagous organisms produce a suite of salivary proteins which interact with the host's coagulation machinery to facilitate the acquisition and digestion of a bloodmeal. Many of these biomolecules inhibit the central blood-clotting serine protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62b200a1628977e0588688668e3c323
https://doi.org/10.1073/pnas.1905177116
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5
Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration
Autor: Trent M. Woodruff, Mike C. L. Wu, John D. Lee, Marc J. Ruitenberg
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 205(10)
Neutrophil infiltration to ischemic tissues following reperfusion worsens injury. A key driver of neutrophil recruitment and activation is the complement factor C5a, which signals through two receptors, C5aR1 and C5aR2. In this study, we used a neutr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5593ab58b3f5f34610beca5567754b3
https://pubmed.ncbi.nlm.nih.gov/33028618
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6
Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor
Autor: Mike C. L. Wu, Trent M. Woodruff, Philip M. Hansbro, Zoe Schofield, Mark E. Cooper
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(8)
Free fatty acid 2 receptor (FFA2) is highly expressed on neutrophils and, when activated by its cognate ligand acetate, generates potent anti-inflammatory activities. The roles of FFA2 and acetate have not been explored in ischemia-reperfusion injury
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0850c21372e3bfce7fe69a16cd429e2
https://pubmed.ncbi.nlm.nih.gov/32725930
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7
Thromboinflammatory Functions of Platelets in Ischemia–Reperfusion Injury and Its Dysregulation in Diabetes
Autor: Yuping Yuan, Mike C. L. Wu, Sophie Maiocchi, Imala Alwis, Shaun P. Jackson
Publikováno v: Seminars in Thrombosis and Hemostasis. 44:102-113
Ischemia–reperfusion (IR) injury is a common complication of a variety of cardiovascular diseases, including ischemic stroke and myocardial infarction (MI). While timely re-establishment of blood flow in a thrombosed artery is the primary goal of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c051167f916b4e85ad6e51380773fa71
https://doi.org/10.1055/s-0037-1613694
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10
Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles
Autor: Mehran Kianinia, Dayong Jin, Baoming Wang, Xuchen Shan, Qian Peter Su, Shaun P. Jackson, Chaohao Chen, Peng Xi, Fan Wang, Mike C. L. Wu, Shihui Wen, Milos Toth, Yongtao Liu, Du Li, Igor Aharonovich
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Nature Communications
Multiphoton fluorescence microscopy (MPM), using near infrared excitation light, provides increased penetration depth, decreased detection background, and reduced phototoxicity. Using stimulated emission depletion (STED) approach, MPM can bypass the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c202c49e158d71b32d46bdaea7b289
https://doi.org/10.1038/s41467-018-05842-w
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